Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
Public ClinicalTrials.gov record NCT07453888. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized, Multicenter, Vehicle-Controlled, Double-Masked Phase 3 Study to Evaluate the Efficacy and Safety of Intranasal Cenegermin (Recombinant Human Nerve Growth Factor [rhNGF]) in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a phase 3, randomized, multicenter, vehicle-controlled, double-masked study to evaluate the efficacy and safety of intranasal cenegermin compared with vehicle control in adult participants with NAION. Approximately 272 participants who meet all eligibility criteria will be randomly assigned in a 1:1 ratio to receive either cenegermin treatment (Group 1) or the vehicle control (Group 2).
Study identification
- NCT ID
- NCT07453888
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 272 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 50 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 1, 2026 (Actual)
- Primary completion
- Sep 2027 (Estimated)
- Completion
- Sep 2027 (Estimated)
- Last update posted
- Sep 10, 2026
2026 – 2027
United States locations
- U.S. sites
- 22
- U.S. states
- 15
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Neuro Eye Orbit Institute | Los Angeles | California | 90048 | Recruiting |
| David Geffen School of Medicine at UCLA - Ophthalmology | Los Angeles | California | 90095 | Not yet recruiting |
| California Orbital Consultants | Newport Beach | California | 92660 | Recruiting |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | Recruiting |
| Bascom Palmer Eye Institute, University of Miami School of Medicine | Miami | Florida | 33136 | Not yet recruiting |
| Sarasota Retina Institute - Research | Sarasota | Florida | 34239 | Recruiting |
| Emory University - Emory Eye Center - Atlanta | Atlanta | Georgia | 30322 | Recruiting |
| Northwestern University - Ophthalmology | Chicago | Illinois | 60611 | Not yet recruiting |
| University of Illinois at Chicago Eye and Ear Infirmary - Ophthalmology | Chicago | Illinois | 60612 | Not yet recruiting |
| Univ. Of Kentucky Clinic Dept of Ophthalmology & Vision Science | Lexington | Kentucky | 40508 | Not yet recruiting |
| The Johns Hopkins Hospital (JHH) | Baltimore | Maryland | 21287 | Not yet recruiting |
| Tufts Medical Center - Neurology | Boston | Massachusetts | 02116 | Recruiting |
| University of Michigan Health - Kellogg Eye Center | Ann Arbor | Michigan | 48105 | Recruiting |
| Trinity Health Grand Rapids | Grand Rapids | Michigan | 49503 | Recruiting |
| University of Minnesota, Dept of Ophthalmology | Minneapolis | Minnesota | 55455 | Not yet recruiting |
| Mayo Clinic - Department of Ophthalmology | Rochester | Minnesota | 55905 | Recruiting |
| Washington University School of Medicine in St Louis - Ophthalmology | St Louis | Missouri | 63108 | Recruiting |
| Duke Eye Center - Ophthalmology | Durham | North Carolina | 27705 | Recruiting |
| University of Pennsylvania - Ophthalmology | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Wills Eye Hospital | Philadelphia | Pennsylvania | 19107 | Not yet recruiting |
| Retina Consultants of South Carolina, Charleston Neuroscience Institute- West Ashley (RCA) | Charleston | South Carolina | 29414 | Recruiting |
| Neuro Eye Clinical Trials | Houston | Texas | 77074 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07453888, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 10, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07453888 live on ClinicalTrials.gov.