Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
Public ClinicalTrials.gov record NCT07453888. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized, Multicenter, Vehicle-Controlled, Double-Masked Phase 3 Study to Evaluate the Efficacy and Safety of Intranasal Cenegermin (Recombinant Human Nerve Growth Factor [rhNGF]) in Adult Participants With Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION)
Study identification
- NCT ID
- NCT07453888
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Dompé Farmaceutici S.p.A
- Industry
- Enrollment
- 272 participants
Conditions and interventions
Interventions
- Cenegermin Drug
- Vehicle Other
Drug · Other
Eligibility (public fields only)
- Age range
- 50 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 29, 2026
- Primary completion
- Aug 31, 2027
- Completion
- Aug 31, 2027
- Last update posted
- Jun 21, 2026
2026 – 2027
United States locations
- U.S. sites
- 18
- U.S. states
- 12
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Neuro Eye Orbit Institute | Los Angeles | California | 90048 | Recruiting |
| David Geffen School of Medicine at UCLA - Ophthalmology | Los Angeles | California | 90095 | Not yet recruiting |
| California Orbital Consultants | Newport Beach | California | 92660 | Not yet recruiting |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | Not yet recruiting |
| Bascom Palmer Eye Institute, University of Miami School of Medicine | Miami | Florida | 33136 | Not yet recruiting |
| Sarasota Retina Institute - Research | Sarasota | Florida | 34239 | Not yet recruiting |
| Northwestern University - Ophthalmology | Chicago | Illinois | 60611 | Not yet recruiting |
| University of Illinois at Chicago Eye and Ear Infirmary - Ophthalmology | Chicago | Illinois | 60612 | Not yet recruiting |
| Univ. Of Kentucky Clinic Dept of Ophthalmology & Vision Science | Lexington | Kentucky | 40508 | Not yet recruiting |
| The Johns Hopkins Hospital (JHH) | Baltimore | Maryland | 21287 | Not yet recruiting |
| Tufts Medical Center - Neurology | Boston | Massachusetts | 02116 | Not yet recruiting |
| University of Michigan Health - Kellogg Eye Center | Ann Arbor | Michigan | 48105 | Not yet recruiting |
| Trinity Health Grand Rapids | Grand Rapids | Michigan | 49503 | Not yet recruiting |
| University of Minnesota, Dept of Ophthalmology | Minneapolis | Minnesota | 55455 | Not yet recruiting |
| Mayo Clinic - Department of Ophthalmology | Rochester | Minnesota | 55905 | Recruiting |
| University of Pennsylvania - Ophthalmology | Philadelphia | Pennsylvania | 19104 | Not yet recruiting |
| Retina Consultants of South Carolina, Charleston Neuroscience Institute- West Ashley (RCA) | Charleston | South Carolina | 29414 | Recruiting |
| Neuro Eye Clinical Trials | Houston | Texas | 77074 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07453888, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 21, 2026 · Synced Jun 26, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07453888 live on ClinicalTrials.gov.