Dose Ranging Study of ORKA-002 in Patients With Moderate-to-Severe Plaque Psoriasis

ClinicalTrials.gov ID: NCT07474792

Public ClinicalTrials.gov record NCT07474792. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 18, 2026, 10:24 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multicenter, Randomized, Double-Blinded, Placebo- Controlled, Dose-Range Finding Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of ORKA-002 in Participants With Moderate-to-Severe Plaque Psoriasis

Study identification

NCT ID: NCT07474792
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Oruka Therapeutics, Inc.; Industry
Enrollment: 160 participants

Conditions and interventions

Conditions

Plaque Psoriasis

Interventions

ORKA-002 Drug
Placebo Other

Drug · Other

Eligibility (public fields only)

Age range: 18 Years to 79 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 18, 2026
Primary completion: Sep 30, 2027
Completion: Mar 31, 2029
Last update posted: Apr 21, 2026

2026 – 2029

United States locations

U.S. sites: 18
U.S. states: 14
U.S. cities: 18

Facility	City	State	ZIP	Site status
Total Skin & Beauty Dermatology Center, PC DBA Total Dermatology	Birmingham	Alabama	35203	Recruiting
First OC Dermatology Research, Inc.	Fountain Valley	California	92708	Recruiting
TCR Medical Corporation	San Diego	California	92123	Recruiting
Southern California Clinical Research	Santa Ana	California	92701	Recruiting
Institute of Clinical Research and Consulting, Inc., d/b/a Clinical Science Institute	Santa Monica	California	90404	Recruiting
Central Connecticut Dermatology Research, PLLC	Cromwell	Connecticut	06416	Recruiting
Driven Research LLC	Coral Gables	Florida	33134	Recruiting
Kuchnir Dermatology & Dermatologic Surgery	Milford	Massachusetts	01757	Recruiting
Henry Ford Medical Center	Detroit	Michigan	48202	Recruiting
Grekin Skin Institute	Warren	Michigan	48088	Recruiting
Associated Skin Care Specialists, PA d/b/a Minnesota Clinical Study Center	New Brighton	Minnesota	55112	Recruiting
Skin Specialists, PC dba Schlessinger MD	Omaha	Nebraska	68144	Recruiting
Icahn School of Medicine at Mount Sinai, Department of Dermatology	New York	New York	10029	Recruiting
WDC Cosmetic and Research, PLLC	Wilmington	North Carolina	28405	Recruiting
Bexley Dermatology Research	Bexley	Ohio	43209	Recruiting
Clear Choice Dermatology LLC	Warrenton	Oregon	97146	Recruiting
Modern Research Associates, PLLC	Dallas	Texas	75231	Recruiting
Frontier Derm Partners CRO LLC	Mill Creek	Washington	98012	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 9 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07474792, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 21, 2026 · Synced May 18, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07474792 live on ClinicalTrials.gov.

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