A Study of VARIPULSE Catheter in Participants With Persistent Atrial Fibrillation Undergoing Pulmonary Vein and Superior Vena Cava Isolation
Public ClinicalTrials.gov record NCT07527299. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Assessment of the Safety and Effectiveness of the VARIPULSE™ Catheter System in the Treatment of Participants With Persistent Atrial Fibrillation Undergoing Pulmonary Vein (With or Without Posterior Wall Isolation) and Superior Vena Cava Isolation: A Randomized Controlled Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess how safe VARIPULSE catheter system is for treatment of a heart rhythm disease called persistent atrial fibrillation (PsAF) in participants who are having a catheter ablation procedure (treat heart rhythm disease). This includes isolation of pulmonary vein and superior vena cava (heart veins; pulmonary vein isolation \[PVI\] and superior vena cava isolation \[SVCI\]), with or without another technique called posterior wall isolation (PWI). Also, to assess how safe it is for participants who are having a catheter ablation procedure and at the same time receiving another procedure called left atrial appendage occlusion (LAAO; to reduce stroke risk). Additionally, to assess how well VARIPULSE catheter system works over a long period of time for treatment of PsAF in participants undergoing catheter ablation for PVI, SVCI and SVCI+PWI.
Study identification
- NCT ID
- NCT07527299
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 1,070 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 26, 2026 (Actual)
- Primary completion
- Nov 30, 2028 (Estimated)
- Completion
- Aug 24, 2031 (Estimated)
- Last update posted
- Sep 25, 2026
2026 – 2031
United States locations
- U.S. sites
- 11
- U.S. states
- 11
- U.S. cities
- 11
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Grandview Medical Center | Birmingham | Alabama | 35243 | Recruiting |
| Pima Heart and Vascular | Tucson | Arizona | 85741 | Recruiting |
| Arrhythmia Research Group | Jonesboro | Arkansas | 72401 | Recruiting |
| Pacific Heart Institute Cedars Sinai Medical Center | Santa Monica | California | 90404 | Recruiting |
| Aurora Denver Cardiology Associates | Aurora | Colorado | 80012 | Recruiting |
| Hartford Hospital | Hartford | Connecticut | 06102 | Recruiting |
| Saint Elizabeth Medical Center | Edgewood | Kentucky | 41017 | Recruiting |
| Albert Einstein College Of Medicine - Montefiore Medical Center | The Bronx | New York | 10467 | Recruiting |
| Oklahoma Heart Hospital | Oklahoma City | Oklahoma | 73120 | Recruiting |
| Penn Presbyterian Medical Center | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Mercy Hospital | Janesville | Wisconsin | 53548 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07527299, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 25, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07527299 live on ClinicalTrials.gov.