ClinicalTrials.gov record
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
ClinicalTrials.gov ID: NCT07567001
Public ClinicalTrials.gov record NCT07567001. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of NNC0487-0111 Compared to Placebo on Morbidity and Mortality in People With Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced Ejection Fraction (HFmrEF) and excess body weight when compared to placebo. The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have HFpEF or HFmrEF and excess body weight. Participants will get NNC0487-0111 or placebo by injection once a week. Which treatment participants get is decided by chance. NNC0487-0111 is a new medicine that doctors cannot prescribe yet, but it has been tested in people before.
Study identification
- NCT ID
- NCT07567001
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 5,610 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 10, 2026
- Primary completion
- Jul 22, 2029
- Completion
- Aug 14, 2029
- Last update posted
- Aug 17, 2026
2026 – 2029
United States locations
- U.S. sites
- 206
- U.S. states
- 38
- U.S. cities
- 176
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Advanced Cardiovascular, LLC | Alexander City | Alabama | 35010 | Recruiting |
| Univ of Alabama Birmingham | Birmingham | Alabama | 35233 | Not yet recruiting |
| Eastern Shore Rsrch Inst, LLC | Fairhope | Alabama | 36532 | Recruiting |
| Mobile Heart USA Health Cardiology Clinic | Mobile | Alabama | 36608 | Not yet recruiting |
| Mercy Gilbert Medical Center | Gilbert | Arizona | 85297 | Recruiting |
| Sun City Clinical Research | Glendale | Arizona | 85304 | Recruiting |
| Honor Health | Phoenix | Arizona | 85006 | Not yet recruiting |
| Arizona Research Center | Phoenix | Arizona | 85016 | Not yet recruiting |
| Arkansas Health Group | Little Rock | Arkansas | 72205 | Not yet recruiting |
| InvivoCure -2 | Alhambra | California | 91801 | Recruiting |
| Cardio Research of S. Cal | Beverly Hills | California | 90210 | Recruiting |
| Westside Medical Associates Los Angeles | Beverly Hills | California | 90211 | Recruiting |
| Scripps Hospital | Chula Vista | California | 91910 | Recruiting |
| John Muir Physicians Network | Concord | California | 94520 | Recruiting |
| Valley Clinical Trials | Covina | California | 91723 | Recruiting |
| Mission Cardiovascular Research Institute | Fremont | California | 94538 | Recruiting |
| Amicis Research Center | Granada Hills | California | 91344 | Recruiting |
| California Heart Specialist | Huntington Beach | California | 92648-1717 | Recruiting |
| Valiance Clinical Research | Huntington Park | California | 90255 | Recruiting |
| Joe C.Wen & Fam CTR for Adv Care | Irvine | California | 92612 | Not yet recruiting |
| Scripps Memorial Hospital La Jolla | La Jolla | California | 92037 | Not yet recruiting |
| UCSD NAFLD Research Center | La Jolla | California | 92037 | Not yet recruiting |
| Cardio Innovation & Resch Ctr | Long Beach | California | 90813 | Recruiting |
| Pacific Clinical Studies | Los Alamitos | California | 90720 | Recruiting |
| VAGrtrLosAngelesHlthcareSystem | Los Angeles | California | 90073 | Not yet recruiting |
| Amicis Research Center | Northridge | California | 91324 | Recruiting |
| JPJ Research | Northridge | California | 91324 | Recruiting |
| Valley Clinical Trials | Northridge | California | 91325 | Recruiting |
| Desert Oasis Healthcare | Palm Springs | California | 92262 | Recruiting |
| Empire Clin. Research | Pomona | California | 91767 | Not yet recruiting |
| G&J Research | San Diego | California | 92117 | Recruiting |
| San Diego Veterans Affairs | San Diego | California | 92161 | Recruiting |
| Kaiser Permanente Northern California | San Francisco | California | 94118 | Not yet recruiting |
| San Francisco V.A. Medical Center | San Francisco | California | 94121 | Not yet recruiting |
| Fomat Medical Research | Santa Maria | California | 93454 | Recruiting |
| NorthBay Clinical Research | Santa Rosa | California | 95405 | Recruiting |
| St. Joseph's Medical Center | Stockton | California | 95204 | Not yet recruiting |
| Valiance Clinical Research | Tarzana | California | 91356 | Recruiting |
| Care Access Research | Thousand Oaks | California | 91360 | Recruiting |
| InvivoCure | Van Nuys | California | 91405 | Recruiting |
| Blue Coast Research Center | Vista | California | 92081 | Recruiting |
| Interventional Cardiology Medical Group | West Hills | California | 91307 | Recruiting |
| Univ of Colorado at Denver | Aurora | Colorado | 80045 | Recruiting |
| VA Eastern Colorado Health Care System | Aurora | Colorado | 80045 | Not yet recruiting |
| Intermountain Heart & Vascular | Denver | Colorado | 80218 | Not yet recruiting |
| Colorado Heart and Vascular PC | Golden | Colorado | 80401 | Recruiting |
| The GW Medical Faculty Associates | Washington D.C. | District of Columbia | 20037 | Not yet recruiting |
| BayCare Health System | Clearwater | Florida | 33756 | Recruiting |
| Broward Research Ctr. | Coral Gables | Florida | 33134 | Recruiting |
| Nature Coast Clinical Research | Crystal River | Florida | 34429 | Recruiting |
| Arrow Clinical Trials | Daytona Beach | Florida | 32117 | Recruiting |
| Inpatient Research Clinic LLC | Florida City | Florida | 33034 | Recruiting |
| Jacksonville Ctr for Clin Res | Jacksonville | Florida | 32216 | Recruiting |
| K2 Medical Research | Maitland | Florida | 32751 | Recruiting |
| Total Research Group LLC | Miami | Florida | 33126 | Recruiting |
| Infinite Clinical Research | Miami | Florida | 33133-4223 | Recruiting |
| Future Life Clinical Trials | Miami | Florida | 33169 | Recruiting |
| Broward Research Ctr. | Miami Beach | Florida | 33140 | Recruiting |
| Inpatient Research Clinic LLC | Miami Lakes | Florida | 33014 | Recruiting |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | Recruiting |
| Ocala Cardiovascular Research | Ocala | Florida | 34471 | Recruiting |
| Cardiovascular Institute of Orlando | Orlando | Florida | 32807 | Recruiting |
| Ormond Beach Clinical Research | Ormond Beach | Florida | 32174 | Recruiting |
| DBC Research - Pembroke Pines | Pembroke Pines | Florida | 33029-1406 | Recruiting |
| SEC Clinical Research | Pensacola | Florida | 32503 | Recruiting |
| Clearwater Cardiovascular Consultants | Safety Harbor | Florida | 34695 | Recruiting |
| Intercoastal Medical Group | Sarasota | Florida | 34239 | Not yet recruiting |
| St Joseph's Hospital Foundation | Tampa | Florida | 33607 | Recruiting |
| Tampa Cardiovascular Interventions and Research | Tampa | Florida | 33614 | Recruiting |
| Hope Research Network | Virginia Gardens | Florida | 33166 | Recruiting |
| Guardian Research Org LLC | Winter Park | Florida | 32792 | Recruiting |
| American Clinical Trials, LLC | Acworth | Georgia | 30101 | Recruiting |
| Atlanta Center for Clinical Research_Atlanta | Atlanta | Georgia | 30342 | Recruiting |
| East Atlanta Cardiology | Conyers | Georgia | 30012 | Recruiting |
| Hope Clin Res & Wellness | Conyers | Georgia | 30094 | Recruiting |
| Northeast Georgia Medical Ctr | Gainesville | Georgia | 30501 | Recruiting |
| NSC Research, Inc | Johns Creek | Georgia | 30024 | Recruiting |
| Peachtree Cardiology | Peachtree | Georgia | 30269 | Recruiting |
| Cardiovascular Consultants of South Georgia | Thomasville | Georgia | 31792 | Recruiting |
| Atlanta Heart Specialists, LLC | Tucker | Georgia | 30084 | Recruiting |
| The Queen's Medical Center | Honolulu | Hawaii | 96813 | Not yet recruiting |
| High Desert Heart and Vascular PLLC | Meridian | Idaho | 83642 | Not yet recruiting |
| St. Luke's Idaho Cardiology Associates | Meridian | Idaho | 83642 | Not yet recruiting |
| Chicago Clinical Research Institute INC | Chicago | Illinois | 60607 | Recruiting |
| Univer Of Illinois at Chicago | Chicago | Illinois | 60612 | Not yet recruiting |
| Eagle Clinical Research | Chicago | Illinois | 60621 | Recruiting |
| Chicago Medical Research LLC | Hazel Crest | Illinois | 60429 | Recruiting |
| Chicago Clinical Research Institute INC | Orland Park | Illinois | 60462 | Recruiting |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61603 | Recruiting |
| Asha Clinical Rsch-Munster, LLC | Hammond | Indiana | 46324 | Recruiting |
| Indiana University Health Methodist Hospital | Indianapolis | Indiana | 46202 | Recruiting |
| Midwest Cardiovascu Rsrch Foundation | Davenport | Iowa | 52801 | Not yet recruiting |
| University OF Iowa | Iowa City | Iowa | 52242 | Not yet recruiting |
| West Houston Area Clinical Trial Consultants | Wichita | Kansas | 67226 | Not yet recruiting |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | Recruiting |
| UofL Health Care Outpatient | Louisville | Kentucky | 40202 | Not yet recruiting |
| Research Integrity Global, LLC | Owensboro | Kentucky | 42303 | Recruiting |
| Grace Research, LLC | Bossier City | Louisiana | 71111 | Recruiting |
| Horizon Research Group of Opelousas, LLC | Eunice | Louisiana | 70535 | Recruiting |
| Cardiovascular Institute of the South | Houma | Louisiana | 70360-4413 | Recruiting |
| Cardiovascular Institute of the South | Opelousas | Louisiana | 70570 | Recruiting |
| Grace Research, LLC_Shreveport | Shreveport | Louisiana | 71105 | Not yet recruiting |
| MaineHealth Cardiology - Biddeford | Biddeford | Maine | 04005 | Not yet recruiting |
| Ascension Saint Agnes Heart Ca | Baltimore | Maryland | 21229 | Not yet recruiting |
| Mercy Medical Center, GI Research | Baltimore | Maryland | 21229 | Not yet recruiting |
| Flourish Research Bowie | Bowie | Maryland | 20715 | Recruiting |
| Anderson Medical Group | Ft. Washington | Maryland | 20744 | Recruiting |
| Adventist HealthCare Shady Grove Medical Center | Rockville | Maryland | 20850 | Recruiting |
| Cardio and Vascular Assoc-CAVA | Bloomfield Hills | Michigan | 48304 | Recruiting |
| Corewell Health | Grand Rapids | Michigan | 49525 | Not yet recruiting |
| University Of Michigan | Lansing | Michigan | 48912 | Recruiting |
| Henry Ford Health System | Southfield | Michigan | 48075 | Recruiting |
| Trinity Health Michigan Heart | Ypsilanti | Michigan | 48197 | Recruiting |
| Hawthorne Health | Diamondhead | Mississippi | 39525 | Not yet recruiting |
| Univ of Mississippi Med Center | Jackson | Mississippi | 39216 | Not yet recruiting |
| Clinical Research Consultants, JCCT Co | Kansas City | Missouri | 64111 | Recruiting |
| Washington University | St Louis | Missouri | 63110 | Recruiting |
| Amicis Centers of Clinical Research | St Louis | Missouri | 63128 | Recruiting |
| Bryan Heart | Lincoln | Nebraska | 68506 | Not yet recruiting |
| Velocity Clinical Research Lincoln | Lincoln | Nebraska | 68510 | Recruiting |
| UMC of Southern Nevada | Las Vegas | Nevada | 89102 | Not yet recruiting |
| Palm Research Center Inc-Vegas | Las Vegas | Nevada | 89128 | Recruiting |
| Heart House - Vineland | Elmer | New Jersey | 08318 | Not yet recruiting |
| Advanced Cardiology LLC - Hackettstown | Hackettstown | New Jersey | 07840 | Not yet recruiting |
| The Heart House Haddon Heights | Haddon Heights | New Jersey | 08035 | Not yet recruiting |
| Jersey City Medical Center | Jersey City | New Jersey | 07302 | Not yet recruiting |
| The Valley Hospital Paramus | Paramus | New Jersey | 07652 | Not yet recruiting |
| AtlantiCare Regional Medical Center | Pomona | New Jersey | 08240 | Not yet recruiting |
| Heart House - Sewell | Sewell | New Jersey | 08080 | Recruiting |
| Cardio Metabolic Institute | Somerset | New Jersey | 08873 | Recruiting |
| Capital Cardiology Associates_Albany | Albany | New York | 12211 | Recruiting |
| Clindove Research | Brooklyn | New York | 11201 | Recruiting |
| NYU Langone Med Assoc Chelsea | New York | New York | 10001 | Not yet recruiting |
| NYU Langone Orthopedic Center | New York | New York | 10016 | Not yet recruiting |
| Mount Sinai Hosp at NYC | New York | New York | 10029 | Not yet recruiting |
| Columbia University Medical Center_New York | New York | New York | 10032 | Not yet recruiting |
| University of Rochester | Rochester | New York | 14642 | Not yet recruiting |
| Laurelton Heart Specialist PC | Rosedale | New York | 11422 | Not yet recruiting |
| Westchester Medical Center | Valhalla | New York | 10595 | Not yet recruiting |
| Peak Clinical Trials | Apex | North Carolina | 27502 | Recruiting |
| Hawthorne Health NC | Concord | North Carolina | 28025 | Recruiting |
| Duke University | Durham | North Carolina | 27710 | Not yet recruiting |
| Physicians East Endocrinology | Greenville | North Carolina | 27834 | Not yet recruiting |
| IMA Research | Lenoir | North Carolina | 28645 | Recruiting |
| WakeMed_Cardiology | Raleigh | North Carolina | 27610 | Not yet recruiting |
| PHC Accelacare | Statesville | North Carolina | 28625 | Recruiting |
| Accellacare Wilmington | Wilmington | North Carolina | 28401 | Not yet recruiting |
| Aultman Hospital | Canton | Ohio | 44710 | Not yet recruiting |
| Lindner Center,Christ Hospital | Cincinnati | Ohio | 45219 | Not yet recruiting |
| Louis Stokes Clvlnd VA Med Ctr | Cleveland | Ohio | 44106 | Not yet recruiting |
| Providence Health Partners Ctr | Dayton | Ohio | 45439 | Recruiting |
| K&R Research Llc | Marion | Ohio | 43302 | Recruiting |
| Advanced Medical Research | Maumee | Ohio | 43537 | Recruiting |
| STAT Research Ohio | Vandalia | Ohio | 45377 | Recruiting |
| Oregon Health & Science University | Portland | Oregon | 97239-3011 | Not yet recruiting |
| Penn State Hlth Holy Spirit Med Ctr | Camp Hill | Pennsylvania | 17011 | Not yet recruiting |
| Chambersburg Hospital | Chambersburg | Pennsylvania | 17201 | Not yet recruiting |
| Doylestown Heath cardiology | Doylestown | Pennsylvania | 18901 | Not yet recruiting |
| Penn Med. Lancaster Gen Hospital | Lancaster | Pennsylvania | 17603 | Recruiting |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | Not yet recruiting |
| Med. Uni. of SC Ashley River T | Charleston | South Carolina | 29425 | Recruiting |
| Piedmont Research Partners, LLC | Fort Mill | South Carolina | 29707 | Recruiting |
| Monument Health Clinical Rsrch | Rapid City | South Dakota | 57701 | Not yet recruiting |
| Balad Hlth Sys-Welmont CardCVA | Greeneville | Tennessee | 37745 | Recruiting |
| The Jackson Clinic, PA | Jackson | Tennessee | 38305 | Recruiting |
| PharmaTex Research, LLC | Amarillo | Texas | 79106 | Recruiting |
| Austin Heart | Austin | Texas | 78705 | Not yet recruiting |
| Javara Inc. / Privia Medical Group Gulf Coast PLLC | Conroe | Texas | 77384 | Recruiting |
| South Texas Clinical Research | Corpus Christi | Texas | 78404 | Recruiting |
| Renal Disease Research Institute | Dallas | Texas | 75204 | Recruiting |
| Texas Health Heart and Vascular Specialists | Dallas | Texas | 75231 | Not yet recruiting |
| Southwest Family Medicine_Dallas | Dallas | Texas | 75235 | Recruiting |
| UTD SW Medical Center-Dallas | Dallas | Texas | 75390 | Recruiting |
| Texama Medical Center | Denison | Texas | 75020 | Recruiting |
| Dallas Heart and Vascular | Duncanville | Texas | 75137 | Recruiting |
| Proactive El Paso LLC | El Paso | Texas | 79902 | Recruiting |
| David Turbay, MD, PLLC | El Paso | Texas | 79905 | Recruiting |
| Care United Research, LLC | Forney | Texas | 75126 | Recruiting |
| Baylor Scott & White Health | Fort Worth | Texas | 76104 | Not yet recruiting |
| East Texas Cardiology PA | Houston | Texas | 77002 | Recruiting |
| Victorium Clinical Research | Houston | Texas | 77024 | Recruiting |
| Main Heart Clinic | Houston | Texas | 77025 | Recruiting |
| Card Specialists of Willowbrook | Houston | Texas | 77070 | Recruiting |
| Biopharma Informatic, LLC | McAllen | Texas | 78503 | Recruiting |
| North Texas Research Associates | McKinney | Texas | 75071 | Recruiting |
| Baylor Scott & White Res Inst | Plano | Texas | 75093 | Not yet recruiting |
| Baylor Scott & White Health | Round Rock | Texas | 78665 | Not yet recruiting |
| University Hospital | San Antonio | Texas | 78229 | Recruiting |
| Austin Heart | San Marcos | Texas | 78666 | Not yet recruiting |
| Sherman Clinical Research | Sherman | Texas | 75090 | Recruiting |
| Medrasa Clinical Research | Sherman | Texas | 75092 | Recruiting |
| Baylor Scott & White Health | Temple | Texas | 76508 | Not yet recruiting |
| Intermountain Medical Center | Murray | Utah | 84107 | Not yet recruiting |
| University Of Virginia Hospital | Charlottesville | Virginia | 22908 | Not yet recruiting |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | Not yet recruiting |
| TPMG Clinical Research | Newport News | Virginia | 23606 | Recruiting |
| Sentara Health Research Center | Norfolk | Virginia | 23507 | Recruiting |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | Not yet recruiting |
| Conquest Research | Vienna | Virginia | 22182 | Recruiting |
| Selma Medical Associates | Winchester | Virginia | 22601-3834 | Recruiting |
| Swedish Medical Center_Seattle | Seattle | Washington | 98122 | Not yet recruiting |
| CHI Franciscan Research Center | Tacoma | Washington | 98405 | Not yet recruiting |
| WVU Medicine | Morgantown | West Virginia | 26506 | Not yet recruiting |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | Not yet recruiting |
| Aurora St. Luke's Medi Ctr | Milwaukee | Wisconsin | 53215 | Not yet recruiting |
| Cardio Research & Education Foundation | Wausau | Wisconsin | 54401 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 632 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07567001, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 17, 2026 · Synced Sep 7, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07567001 live on ClinicalTrials.gov.