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Recruiting Phase 3 Interventional

A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

ClinicalTrials.gov ID: NCT07573176

Public ClinicalTrials.gov record NCT07573176. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 17, 2026, 3:11 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multicenter, Double-blind, Randomized, Placebo-controlled Study to Evaluate Efficacy and Safety of Seltorexant as Monotherapy in Adult and Elderly Participants With Major Depressive Disorder (MDD) and an Open-label Long-term Extension Treatment With Seltorexant

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The main purpose of this study is to assess how well the study drug (JNJ-42847922) works (efficacy) compared with placebo in improving depressive symptoms in participants with major depressive disorder (\[MDD\], a common mood disorder that causes a lasting feeling of sadness and a loss of interest in everyday activities) in double-blind treatment phase. Further, to evaluate long-term safety and tolerability of JNJ-42847922 in participants with MDD in the open label treatment phase.

Study identification

NCT ID
NCT07573176
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Enrollment
600 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years to 74 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Apr 30, 2026 (Actual)
Primary completion
Aug 24, 2028 (Estimated)
Completion
May 3, 2029 (Estimated)
Last update posted
Oct 1, 2026

2026 – 2029

United States locations

U.S. sites
34
U.S. states
16
U.S. cities
30
Facility City State ZIP Site status
SanRo Clinical Research Group LLC WCG Clinical Network Bryant Arkansas 72022 Recruiting
CI Trials Bellflower California 90706 Recruiting
Behavioral Research Specialists LLC Glendale California 91206 Recruiting
Excell Research Inc Oceanside California 92056 Recruiting
NRC Research Institute Orange California 92868 Recruiting
Cenexel Riverside California 92506 Recruiting
Sunwise Clinical Research Walnut Creek California 94596 Recruiting
UHC Research Doral Florida 33178 Recruiting
Reliable Clinical Research Hialeah Florida 33012 Recruiting
Pharmax Research Clinic Inc Miami Florida 33126 Recruiting
Nuovida Research Center Miami Florida 33186 Recruiting
IPTB Clinical Research Tampa Florida 33629 Recruiting
Health Synergy Clinical Research West Palm Beach Florida 33407 Recruiting
Agile Clinical Research Trials, LLC Atlanta Georgia 30328 Recruiting
Accelerated Clinical Research Group LLC Snellville Georgia 30078 Recruiting
Chicago Research Center Chicago Illinois 60634 Recruiting
Pharmasite Research, Inc. Baltimore Maryland 21208 Recruiting
Adams Clinical Boston Boston Massachusetts 02116 Recruiting
Adams Clinical Watertown Watertown Massachusetts 02472 Recruiting
Vector Clinical Trials Las Vegas Nevada 89128 Recruiting
CenExel Marlton NJ Marlton New Jersey 08053 Recruiting
Integrative Clinical Trials LLC Brooklyn New York 11229 Recruiting
SPRI Clinical Trials, LLC Brooklyn New York 11235 Recruiting
Bioscience Research LLC Mount Kisco New York 10549 Recruiting
Fieve Clinical Research Inc New York New York 10017 Recruiting
Adams Clinical Harlem New York New York 10029 Recruiting
Manhattan Behavioral Medicine New York New York 10036 Recruiting
Magnolia Clinical Research LLC Cary North Carolina 27511 Recruiting
Patient Priority Clinical Sites LLC Cincinnati Ohio 45215 Recruiting
Conrad Clinical Research Edmond Oklahoma 73013 Recruiting
Sooner Clinical Research Oklahoma City Oklahoma 73116 Recruiting
Future Search Trials of Dallas Dallas Texas 75251 Recruiting
Alpine Research Organization Clinton Utah 84015 Recruiting
Northwest Clinical Research Center Bellevue Washington 98007 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 11 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07573176, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 1, 2026 · Synced Oct 17, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07573176 live on ClinicalTrials.gov.

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