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Recruiting Phase 3 Interventional

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

ClinicalTrials.gov ID: NCT07592689

Public ClinicalTrials.gov record NCT07592689. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 21, 2026, 6:15 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled, 12-Week Study (Part A) With a 40-Week Open-label Extension (Part B) Evaluating the Efficacy and Safety of Oral DT120 Compared to Placebo in the Treatment of Adults With Major Depressive Disorder - Ascend

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend

Study identification

NCT ID
NCT07592689
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Definium Therapeutics US, Inc.
Industry
Enrollment
165 participants

Conditions and interventions

Interventions

Other · Drug

Eligibility (public fields only)

Age range
18 Years to 74 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
May 10, 2026 (Actual)
Primary completion
Sep 2027 (Estimated)
Completion
Jun 2028 (Estimated)
Last update posted
Oct 14, 2026

2026 – 2028

United States locations

U.S. sites
30
U.S. states
17
U.S. cities
28
Facility City State ZIP Site status
Preferred Research Partners, Inc. Little Rock Arkansas 72211 Recruiting
ATP Clinical Research Orange County Orange California 92866 Not yet recruiting
Kadima Neuropsychiatry Institute San Diego California 92037 Recruiting
UCSF Department of Neurology San Francisco California 94158 Not yet recruiting
Psychedelic Science Institute Santa Monica California 90404 Recruiting
Mountain View Clinical Research, Inc Denver Colorado 80209 Recruiting
Clinical Neuroscience Solutions, LLC (Jacksonville) Jacksonville Florida 32256 Recruiting
K2 Medical Research (Maitland) Maitland Florida 32751 Recruiting
Clinical Neuroscience Solutions, LLC (Orlando) Orlando Florida 32801 Recruiting
Charter Research Orlando Florida 32803 Not yet recruiting
K2 Medical Research (Tampa) Tampa Florida 33607 Recruiting
CenExel - Atlanta Center for Medical Research Atlanta Georgia 30331 Recruiting
CenExel - iResearch Atlanta Decatur Georgia 30030 Recruiting
CenExel - iResearch Savannah Savannah Georgia 31405 Recruiting
Uptown Research Institute Chicago Illinois 60640 Recruiting
Adams Clinical Boston Boston Massachusetts 02116 Active, not recruiting
Adams Clinical Watertown Boston Massachusetts 02472 Recruiting
Vitalix Clinical Worcester Massachusetts 01608 Recruiting
Arch Clinical Trials, LLC St Louis Missouri 63141 Recruiting
Redbird Research Las Vegas Nevada 89119 Recruiting
Adams Clinical Harlem New York New York 10029 Active, not recruiting
Cleveland Clinic Cleveland Ohio 44113 Not yet recruiting
Adams Clinical Philadelphia Philadelphia Pennsylvania 19104 Recruiting
Coastal Carolina Research North Charleston South Carolina 29405 Recruiting
Austin Clinical Trial Partners Austin Texas 78737 Recruiting
Cedar Clinical Research Draper Utah 84020 Recruiting
Inner Space Research Orem Utah 84058 Recruiting
Memory Clinic Inc. Bennington Vermont 05201 Recruiting
Seattle Neuropsychiatric Treatment Center Seattle Washington 98104 Not yet recruiting
VA Portland Healthcare System Vancouver Washington 98661 Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07592689, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 14, 2026 · Synced Oct 21, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07592689 live on ClinicalTrials.gov.

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