A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

ClinicalTrials.gov ID: NCT07595549

Public ClinicalTrials.gov record NCT07595549. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 23, 2026, 2:25 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF ONCE-MONTHLY PF-08653944 IN ADULTS WITH OVERWEIGHT OR OBESITY (VESPER-6)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes. About 950 adults will be in this study. Berobenatide will be compared to a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. Berobenatide or placebo is given by a shot under the skin in the belly area. The objective of the study is to compare the experiences of people receiving berobenatide to those of the people who do not to assess if the study medicine is effective and safe. People will take part in this study for about 20 months. During this time, they will have about 15 study visits at the site. They will also have 2 study visits over the phone.

Study identification

NCT ID: NCT07595549
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Pfizer; Industry
Enrollment: 954 participants

Conditions and interventions

Conditions

Interventions

PF-08653944 Drug
Placebo Other

Drug · Other

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 9, 2026
Primary completion: May 3, 2028
Completion: Jun 20, 2028
Last update posted: Sep 3, 2026

2026 – 2028

United States locations

U.S. sites: 34
U.S. states: 14
U.S. cities: 29

Facility	City	State	ZIP	Site status
San Fernando Valley Health Institute	Canoga Park	California	91304	Recruiting
Headlands Research California, LLC	Escondido	California	92025	Recruiting
ImmuniMet, LLC	Modesto	California	95350	Recruiting
Clinical Trials Research	Sacramento	California	95821	Recruiting
University Clinical Investigators, Inc.	Tustin	California	92780	Recruiting
Diablo Clinical Research, Inc.	Walnut Creek	California	94598	Recruiting
Southern California Retina Specialists	West Hills	California	91307	Recruiting
Nature Coast Clinical Research	Crystal River	Florida	34429	Recruiting
West Coast Eye Institute	Lecanto	Florida	34461	Recruiting
South Broward Research	Miramar	Florida	33027	Recruiting
Suncoast Clinical Research, Inc.	New Port Richey	Florida	34652	Recruiting
West Coast Medical Associates	New Port Richey	Florida	34652	Recruiting
Center for Diabetes, Obesity and Metabolism Inc	Pembroke Pines	Florida	33024	Recruiting
Cedar Crosse Research Center	Chicago	Illinois	60607	Recruiting
Northwestern University	Chicago	Illinois	60611	Not yet recruiting
Endeavor Health - Family Medicine Administration	Evanston	Illinois	60201	Recruiting
Endeavor Health- Endocrinology Research	Skokie	Illinois	60077	Recruiting
MediSphere Medical Research Center, LLC	Evansville	Indiana	47714	Recruiting
Monroe Biomedical Research	Louisville	Kentucky	40213	Recruiting
Ascension Saint Agnes Heart Care	Baltimore	Maryland	21229	Not yet recruiting
Aa Mrc Llc	Flint	Michigan	48504	Recruiting
University Of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Albuquerque Clinical Trials, Inc.	Albuquerque	New Mexico	87102	Recruiting
Weill Cornell Medicine - Comprehensive Weight Control Center	New York	New York	10021	Recruiting
Rochester Clinical Research, LLC	Rochester	New York	14609	Recruiting
Medication Management LLC	Greensboro	North Carolina	27405	Recruiting
Accellacare - Wilmington	Wilmington	North Carolina	28401	Recruiting
Jeffrey Coleman, OD	Wilmington	North Carolina	28401	Recruiting
Midwest Eye Center	Cincinnati	Ohio	45202	Recruiting
Velocity Clinical Research, Mt. Auburn	Cincinnati	Ohio	45219	Recruiting
PlanIt Research, LLC (Monitoring Room)	Houston	Texas	77079	Recruiting
PlanIt Research, LLC	Houston	Texas	77079	Recruiting
VIP Trials	San Antonio	Texas	78230	Recruiting
York Clinical Research, LLC	Norfolk	Virginia	23504	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 16 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07595549, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 3, 2026 · Synced Sep 23, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07595549 live on ClinicalTrials.gov.

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