A Phase 3 Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia
Public ClinicalTrials.gov record NCT07623200. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Open-Label Study of INCA033989 Versus Best Available Therapy in Participants With Essential Thrombocythemia and a CALR Mutation Previously Treated With Cytoreductive Therapy (EXCALIBUR-ET2)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is being conducted to evaluate INCA033989 versus best available therapy in participants with essential thrombocythemia and a CALR mutation previously treated with cytoreductive therapy.
Study identification
- NCT ID
- NCT07623200
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 426 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 7, 2026
- Primary completion
- Jun 14, 2029
- Completion
- Oct 31, 2030
- Last update posted
- Aug 30, 2026
2026 – 2030
United States locations
- U.S. sites
- 41
- U.S. states
- 22
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner Md Anderson Cancer Center | Gilbert | Arizona | 85234 | Not yet recruiting |
| The University of Arizona Cancer Center | Tucson | Arizona | 85724-5024 | Not yet recruiting |
| City of Hope Medical Center | Duarte | California | 91010 | Not yet recruiting |
| Marin Cancer Care | Greenbrae | California | 94904 | Recruiting |
| University of California, Los Angeles Medical Center | Los Angeles | California | 90095 | Not yet recruiting |
| Stanford Cancer Center | Palo Alto | California | 94304 | Not yet recruiting |
| Rocky Mountain Cancer Centers-Lone Tree | Lone Tree | Colorado | 80124 | Not yet recruiting |
| Medstar Georgetown Medical Center, Inc | Washington D.C. | District of Columbia | 20007 | Not yet recruiting |
| Florida Cancer Specialists & Research Institute | Fort Myers | Florida | 33901 | Not yet recruiting |
| University of Miami Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | Not yet recruiting |
| Cleveland Clinic | Weston | Florida | 33331 | Not yet recruiting |
| Winship Cancer Institute of Emory University | Atlanta | Georgia | 30322 | Not yet recruiting |
| Robert H. Lurie Comprehensive Cancer Center of Northwestern University | Chicago | Illinois | 60611 | Not yet recruiting |
| University of Chicago | Chicago | Illinois | 60637 | Not yet recruiting |
| The University of Kansas Cancer Center | Westwood | Kansas | 66205 | Not yet recruiting |
| Johns Hopkins Medicine-the Sidney Kimmel Comprehensive Cancer Center | Baltimore | Maryland | 21231 | Not yet recruiting |
| Maryland Oncology Hematology, P.A. | Columbia | Maryland | 21044 | Not yet recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Not yet recruiting |
| Beth Israel Deaconess Medical Center (Bidmc) | Boston | Massachusetts | 02215 | Not yet recruiting |
| University of Massachusetts Medical School | Worcester | Massachusetts | 01655 | Not yet recruiting |
| University of Michigan Rogel Cancer Center Adult Bone Marrow Transplant Clinic | Ann Arbor | Michigan | 48109-4000 | Not yet recruiting |
| Missouri Cancer Associates | Columbia | Missouri | 65201 | Not yet recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Not yet recruiting |
| John Theurer Cancer Center, Hackensack University Medical Center | Hackensack | New Jersey | 07601 | Not yet recruiting |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08901 | Not yet recruiting |
| Icahn School of Medicine At Mount Sinai | New York | New York | 10029 | Not yet recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Not yet recruiting |
| Weill Cornell Medical College - Newyork-Presbyterian Hospita | New York | New York | 10065 | Not yet recruiting |
| Strong Memorial Hospital University of Rochester Medical Center | Rochester | New York | 14642 | Not yet recruiting |
| Duke University Medical Center | Durham | North Carolina | 27705 | Not yet recruiting |
| Cleveland Clinic Taussig Cancer Ctr | Cleveland | Ohio | 44195 | Not yet recruiting |
| Willamette Valley Cancer Institute and Research Center | Eugene | Oregon | 97401 | Not yet recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239 | Not yet recruiting |
| Thomas Jefferson University Sidney Kimmel Medical College | Philadelphia | Pennsylvania | 19107 | Not yet recruiting |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232-5735 | Not yet recruiting |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | Not yet recruiting |
| The University of Texas-Md Anderson Cancer Center | Houston | Texas | 77030 | Not yet recruiting |
| Ut Health Science Center At San Antonio | San Antonio | Texas | 78229 | Not yet recruiting |
| Texas Oncology-Tyler | Tyler | Texas | 75702 | Not yet recruiting |
| Huntsman Cancer Institute At University of Utah | Salt Lake City | Utah | 84112 | Not yet recruiting |
| University of Washington - Fred Hutch Cancer Center | Seattle | Washington | 98109 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 136 non-U.S. sites.
Recently updated Essential Thrombocythemia trials
Other public records listing Essential Thrombocythemia. Sorted by last update posted; newest first. Not a recommendation.
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About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07623200, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 30, 2026 · Synced Aug 31, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07623200 live on ClinicalTrials.gov.