Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
ClinicalTrials.gov record
Recruiting Phase 3 Interventional

Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation

ClinicalTrials.gov ID: NCT07626411

Public ClinicalTrials.gov record NCT07626411. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search
ClinicalTrials.gov public records Last synced Oct 17, 2026, 6:12 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Multicenter, Double-blind Study to Assess Stroke and Systemic Embolism Prevention With REGN7508, a Monoclonal Antibody Against Factor XI, Versus Apixaban in Participants With Atrial Fibrillation (ROXI-EVEREST)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study is researching an experimental drug called REGN7508 (called "study drug") and how it compares against another treatment called apixaban. The study is focused on people who have atrial fibrillation, which means that the heart beats too fast and unevenly. The aim of the study is to see how safe and effective REGN7508 is in preventing stroke and/or systemic embolism in participants with atrial fibrillation and how it compares against participants that will receive apixaban in this study. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)

Study identification

NCT ID
NCT07626411
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Regeneron Pharmaceuticals
Industry
Enrollment
15,364 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Aug 10, 2026 (Actual)
Primary completion
Sep 11, 2029 (Estimated)
Completion
Dec 10, 2029 (Estimated)
Last update posted
Oct 8, 2026

2026 – 2029

United States locations

U.S. sites
44
U.S. states
17
U.S. cities
42
Facility City State ZIP Site status
Advanced Cardiovascular Alexander City Alabama 35010 Recruiting
SEC Clinical Research Dothan Alabama 36305 Recruiting
Eastern Shore Research Institute Fairhope Alabama 36532 Recruiting
Sun City Clinical Research Glendale Arizona 85351 Recruiting
Arkansas Cardiology P.A. Little Rock Arkansas 72205 Recruiting
Mission Cardiovascular Research Institute Fremont California 94538 Recruiting
National Institute of California Heart and Vein Specialists Huntington Beach California 92648 Recruiting
Profound Research LLC at San Diego Cardiovascular Associates La Jolla California 92037 Recruiting
Radin Cardiovascular Medical Group Newport Beach California 92663 Recruiting
Valley Clinical Trials, LLC dba Flourish Research Northridge California 91325 Recruiting
Southern California Heart Specialists Pasadena California 91105 Recruiting
FOMAT - Comprehensive Cardiovascular Care Santa Maria California 93454 Recruiting
Cardiology Associates Medical Group Ventura California 93003 Recruiting
Interventional Cardiology Medical Group West Hills California 91307 Recruiting
Nouvelle Clinical Research LLC Cutler Bay Florida 33189 Recruiting
South Florida Research Organization LLC Medley Florida 33166 Recruiting
Healix Clinical Research New Smyrna Beach Florida 32168 Recruiting
Sec Clinical Research Pensacola Florida 32503 Recruiting
Flourish Research, St. Johns Center for Clinical Research Saint Augustine Florida 32086 Recruiting
Cardiovascular Center of Sarasota Foundation for Research and Education Sarasota Florida 34239 Recruiting
Clinical Site Partners, LLC DBA Flourish Research Winter Park Florida 32789 Recruiting
Atlanta Clinical Research Centers Atlanta Georgia 30342 Recruiting
NSC Research, Inc Johns Creek Georgia 30024 Recruiting
Cardiovascular Research of Northwest Indiana, LLC Munster Indiana 46321-4054 Recruiting
Profound Research, Powers Health Medical Group - Electrophysiology Munster Indiana 46321 Recruiting
Monroe Research, LLC West Monroe Louisiana 71291 Recruiting
Anderson Medical Research Ft. Washington Maryland 20744 Recruiting
Profound Research, Cardiology and Vascular Associates (CAVA) - Bloomfield Hills Bloomfield Hills Michigan 48304 Recruiting
Profound Research, Millennium Cardiology Farmington Hills Michigan 48334 Recruiting
Super Health Pharmacy Staten Island New York 10309 Recruiting
Hawthorne Health, Moose Pharmacy of Concord Concord North Carolina 28025 Recruiting
Peters Medical Research High Point North Carolina 27260 Recruiting
K&R Research LLC Marion Ohio 43302 Recruiting
Tennessee Center for Clinical Trials Tullahoma Tennessee 37388 Recruiting
PharmaTex Research Amarillo Texas 79106 Recruiting
PanAmerican Clinical Research Brownsville Texas 78520 Recruiting
Synergy Groups Medical Houston Texas 77061 Recruiting
West Houston Area Clinical Trial Consultants, LLC Houston Texas 77094 Recruiting
Synergy Group Medical, LLC Missouri City Texas 77459 Recruiting
Permian Research Foundation Odessa Texas 79761 Recruiting
Tyler Cardiovascular Consultants Tyler Texas 75701 Recruiting
Alpine Research TC Clinton Utah 84015 Recruiting
Carient Heart & Vascular Manassas Virginia 20109 Recruiting
Conquest Research Vienna Virginia 22182 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07626411, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 8, 2026 · Synced Oct 17, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07626411 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →