A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
Public ClinicalTrials.gov record NCT07654374. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Long-Term Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Multiple Maintenance Doses of Oral Once Daily Aleniglipron for Chronic Weight Management in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is randomized, double-blind, placebo-controlled study of the long-term efficacy, safety, and tolerability of multiple doses of aleniglipron in participants living with overweight or obesity and T2DM. Participants will be randomized to aleniglipron or placebo for a total of 76 weeks of treatment.
Study identification
- NCT ID
- NCT07654374
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,100 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 79 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 17, 2026 (Actual)
- Primary completion
- Sep 2028 (Estimated)
- Completion
- Nov 2028 (Estimated)
- Last update posted
- Sep 11, 2026
2026 – 2028
United States locations
- U.S. sites
- 74
- U.S. states
- 30
- U.S. cities
- 71
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| ACCOMPLISH-2 Research Site | Birmingham | Alabama | 35242 | Recruiting |
| ACCOMPLISH-2 Research Site | Chandler | Arizona | 85225 | Recruiting |
| ACCOMPLISH-2 Research Site | Phoenix | Arizona | 85028 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Sun City West | Arizona | 85375 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Tucson | Arizona | 85741 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Little Rock | Arkansas | 72211 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Escondido | California | 92025 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Fountain Valley | California | 92708 | Recruiting |
| ACCOMPLISH-2 Research Site | La Jolla | California | 92123 | Recruiting |
| ACCOMPLISH-2 Research Site | Lake Forest | California | 92630 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Rolling Hills Estates | California | 90274 | Recruiting |
| ACCOMPLISH-2 Research Site | San Diego | California | 92108 | Recruiting |
| ACCOMPLISH-2 Research Site | Tustin | California | 92780 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Waterbury | Connecticut | 06708 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Clearwater | Florida | 33756 | Recruiting |
| ACCOMPLISH-2 Research Site | Fort Myers | Florida | 33912 | Recruiting |
| ACCOMPLISH-2 Research Site | Jacksonville | Florida | 32216 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Leesburg | Florida | 34748 | Recruiting |
| ACCOMPLISH-2 Research Site | Miami | Florida | 33136 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Ocala | Florida | 34470 | Recruiting |
| ACCOMPLISH-2 Research Site | Ocoee | Florida | 34761 | Recruiting |
| ACCOMPLISH-2 Research Site | Pembroke Pines | Florida | 33027 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Atlanta | Georgia | 30329 | Recruiting |
| ACCOMPLISH-2 Research Site | Columbus | Georgia | 31904 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Lawrenceville | Georgia | 30046 | Recruiting |
| ACCOMPLISH-2 Research Site | Union City | Georgia | 30291 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Woodstock | Georgia | 30189 | Recruiting |
| ACCOMPLISH-2 Research Site | Meridian | Idaho | 83646 | Recruiting |
| ACCOMPLISH-2 Research Site | Des Moines | Iowa | 50314 | Recruiting |
| ACCOMPLISH-2 Research Site | Iowa City | Iowa | 52242 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Wichita | Kansas | 67218 | Recruiting |
| ACCOMPLISH-2 Research Site | Silver Spring | Maryland | 20901 | Recruiting |
| ACCOMPLISH-2 Research Site | Methuen | Massachusetts | 01844 | Recruiting |
| ACCOMPLISH-2 Research Site | Mankato | Minnesota | 56001 | Recruiting |
| ACCOMPLISH-2 Research Site | Minneapolis | Minnesota | 55423 | Recruiting |
| ACCOMPLISH-2 Research Site | Gulfport | Mississippi | 39503 | Recruiting |
| ACCOMPLISH-2 Research Site | Ridgeland | Mississippi | 39157 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Chesterfield | Missouri | 63005 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | City of Saint Peters | Missouri | 63303 | Recruiting |
| ACCOMPLISH-2 Research Site | Hazelwood | Missouri | 63042 | Recruiting |
| ACCOMPLISH-2 Research Site | Springfield | Missouri | 65807 | Recruiting |
| ACCOMPLISH-2 Research Site | St Louis | Missouri | 63141 | Recruiting |
| ACCOMPLISH-2 Research Site | Missoula | Montana | 59804 | Recruiting |
| ACCOMPLISH-2 Research Site | Omaha | Nebraska | 68105 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Las Vegas | Nevada | 89128 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Albany | New York | 12206 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Albany | New York | 12208 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Brooklyn | New York | 11220 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | The Bronx | New York | 10455 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Charlotte | North Carolina | 28210 | Recruiting |
| ACCOMPLISH-2 Research Site | Durham | North Carolina | 27710 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Fayetteville | North Carolina | 28304 | Recruiting |
| ACCOMPLISH-2 Research Site | Morehead City | North Carolina | 23730 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Winston-Salem | North Carolina | 27104 | Recruiting |
| ACCOMPLISH-2 Research Site | Columbus | Ohio | 43213 | Recruiting |
| ACCOMPLISH-2 Research Site | Moore | Oklahoma | 73160 | Recruiting |
| ACCOMPLISH-2 Research Site | Tulsa | Oklahoma | 74133 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Yukon | Oklahoma | 73099 | Recruiting |
| ACCOMPLISH-2 Research Site | Portland | Oregon | 97202 | Recruiting |
| ACCOMPLISH-2 Research Site | Philadelphia | Pennsylvania | 19152 | Recruiting |
| ACCOMPLISH-2 Research Site | Greer | South Carolina | 29651 | Recruiting |
| ACCOMPLISH-2 Research Site | Nashville | Tennessee | 37203 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Austin | Texas | 78704 | Recruiting |
| ACCOMPLISH-2 Research Site | Farmers Branch | Texas | 75234 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Houston | Texas | 77040 | Recruiting |
| ACCOMPLISH-2 Research Site | Houston | Texas | 77054 | Recruiting |
| ACCOMPLISH-2 Research Site | San Antonio | Texas | 78229 | Recruiting |
| ACCOMPLISH-2 Research Site | San Antonio | Texas | 78230 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Wylie | Texas | 75098 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Salt Lake City | Utah | 84107 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Burke | Virginia | 22015 | Not yet recruiting |
| ACCOMPLISH-2 Research Site | Manassas | Virginia | 20110 | Recruiting |
| ACCOMPLISH-2 Research Site | Suffolk | Virginia | 23435 | Recruiting |
| ACCOMPLISH-2 Research Site | Renton | Washington | 98057 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07654374, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 11, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07654374 live on ClinicalTrials.gov.