A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung Cancer

ClinicalTrials.gov ID: NCT07659782

Public ClinicalTrials.gov record NCT07659782. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 24, 2026, 4:47 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2, Open-label Study of VS-7375, an Oral KRAS G12D (ON/OFF) Inhibitor, in Patients With Previously Treated, Advanced KRAS G12D-Mutated Non-Small Cell Lung Cancer (TARGET-D 202)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study will assess the safety and efficacy of VS-7375 alone and in combination with cetuximab in patients with metastatic KRAS G12D - mutated Non-Small Cell Lung Cancer

Study identification

NCT ID: NCT07659782
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Verastem, Inc.; Industry
Enrollment: 105 participants

Conditions and interventions

Conditions

Non-Small Cell Lung Cancer

Interventions

VS-7375 Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 22, 2026 (Actual)
Primary completion: Jun 2027 (Estimated)
Completion: Dec 2028 (Estimated)
Last update posted: Oct 23, 2026

2026 – 2028

United States locations

U.S. sites: 19
U.S. states: 12
U.S. cities: 16

Facility	City	State	ZIP	Site status
HonorHealth Research Institute	Scottsdale	Arizona	85258	Recruiting
START LA	Los Angeles	California	90025	Recruiting
Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
Valkyrie Clinical Trials	Los Angeles	California	90067	Recruiting
University of Colorado Cancer Center	Aurora	Colorado	80045	Recruiting
BRCR Global - Coral Springs	Coral Springs	Florida	33065	Recruiting
BRCR Global- Tamarac	Tamarac	Florida	33321	Recruiting
Moffit Cancer Centre	Tampa	Florida	33612	Recruiting
Emory Winship Cancer Institute	Atlanta	Georgia	30322	Recruiting
University of Chicago	Chicago	Illinois	60637	Recruiting
START New Jersey	East Brunswick	New Jersey	08816	Recruiting
NYU	New York	New York	10016	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of North Carolina at Chapel Hill	Chapel Hill	North Carolina	27599	Recruiting
START Fort Worth	Fort Worth	Texas	76104	Recruiting
MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
University of Utah	Salt Lake City	Utah	84112	Recruiting
University of Virginia	Charlottesville	Virginia	22908	Recruiting
Virginia Cancer Specialists	Fairfax	Virginia	22031	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07659782, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 23, 2026 · Synced Oct 24, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07659782 live on ClinicalTrials.gov.

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