A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide
Public ClinicalTrials.gov record NCT07668414. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of Zenagamtide s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Obesity (AMAZE 7)
Study identification
- NCT ID
- NCT07668414
- Recruitment status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Novo Nordisk A/S
- Industry
- Enrollment
- 650 participants
Conditions and interventions
Conditions
Interventions
- Zenagamtide Drug
- Semaglutide Drug
- Placebo (matched to semaglutide) Drug
- Placebo (matched to zenagamtide) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 21, 2026
- Primary completion
- Oct 9, 2028
- Completion
- Oct 9, 2028
- Last update posted
- Jun 24, 2026
2026 – 2028
United States locations
- U.S. sites
- 46
- U.S. states
- 16
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| First Valley Medical Group | Lancaster | California | 93534 | — |
| Desert Oasis Healthcare | Palm Springs | California | 92262 | — |
| Western University of Health Sciences | Pomona | California | 91766 | — |
| Artemis Insitute for Clin Res | San Diego | California | 92123 | — |
| Med Home Development Grp | Washington D.C. | District of Columbia | 20037 | — |
| Encore Medical Research LLC | Hollywood | Florida | 33024 | — |
| NextPhase Research | Hollywood | Florida | 33024 | — |
| Jacksonville Ctr Clin Res | Jacksonville | Florida | 32216 | — |
| PharmaDev Clinical Research Institute LLC | Miami | Florida | 33176 | — |
| South Broward Research LLC | Miramar | Florida | 33027 | — |
| Essence MD Research | Naples | Florida | 34102 | — |
| Florida Inst For Clin Res LLC | Orlando | Florida | 32825 | — |
| Oviedo Medical Research, LLC | Oviedo | Florida | 32765 | — |
| Palm Beach Research Center | West Palm Beach | Florida | 33409 | — |
| Encore Medical Research of Weston | Weston | Florida | 33331 | — |
| Conquest Research | Atlanta | Georgia | 30328 | — |
| Eastside Bariatric and Gen Surg | Snellville | Georgia | 30078 | — |
| Chicago Research Center, Inc | Chicago | Illinois | 60634 | — |
| Endeavor Health | Skokie | Illinois | 60077 | — |
| Midwest Inst For Clin Res | Indianapolis | Indiana | 46260 | — |
| Southern Clin Research | Zachary | Louisiana | 70791 | — |
| Amicis Centers of Clinical Research | St Louis | Missouri | 63128 | — |
| Ichor Research | Syracuse | New York | 13210 | — |
| Southgate Medical Group, LLP | West Seneca | New York | 14224 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27514 | — |
| PharmQuest Life Sciences LLC | Greensboro | North Carolina | 27408 | — |
| Piedmont Healthcare/Research | Statesville | North Carolina | 28625 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| Geisinger Clinic | Danville | Pennsylvania | 17822 | — |
| Medical University Of South Carolina | Charleston | South Carolina | 29425 | — |
| Hillcrest Clinical Research | Simpsonville | South Carolina | 29681-1538 | — |
| Spartanburg Medical Research | Spartanburg | South Carolina | 29303 | — |
| Amarillo Med Spec LLP | Amarillo | Texas | 79124 | — |
| Texas Diabetes & Endocrinology | Austin | Texas | 78749 | — |
| Pinnacle Clinical Research | Brownsville | Texas | 78520 | — |
| Osvaldo A. Brusco MD | Corpus Christi | Texas | 78414 | — |
| UT Southwestern Med Center | Dallas | Texas | 75390 | — |
| Epic Medical Research | DeSoto | Texas | 75115 | — |
| Houston Research Institute | Houston | Texas | 77079 | — |
| The Endocrine Center | Houston | Texas | 77079 | — |
| Sleep Therapy Research Center | San Antonio | Texas | 78229 | — |
| Olympus Clinical Research | Sugar Land | Texas | 77478 | — |
| National Clin Res Inc. | Richmond | Virginia | 23294 | — |
| Gastroent Consult of SW VA | Roanoke | Virginia | 24014 | — |
| Rainier Clin Res Ctr Inc | Renton | Washington | 98057 | — |
| Seattle Clinical Research Center | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07668414, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 24, 2026 · Synced Jul 24, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07668414 live on ClinicalTrials.gov.