A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

ClinicalTrials.gov ID: NCT07668414

Public ClinicalTrials.gov record NCT07668414. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 25, 2026, 11:48 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Efficacy and Safety of Zenagamtide s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Obesity (AMAZE 7)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.

Study identification

NCT ID: NCT07668414
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Novo Nordisk A/S; Industry
Enrollment: 650 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 22, 2026 (Actual)
Primary completion: Oct 10, 2028 (Estimated)
Completion: Oct 10, 2028 (Estimated)
Last update posted: Sep 28, 2026

2026 – 2028

United States locations

U.S. sites: 45
U.S. states: 16
U.S. cities: 43

Facility	City	State	ZIP	Site status
First Valley Medical Group	Lancaster	California	93534	Recruiting
Desert Oasis Healthcare	Palm Springs	California	92262	Recruiting
Western University of Health Sciences	Pomona	California	91766	Recruiting
Artemis Insitute for Clin Res	San Diego	California	92123	Recruiting
Med Home Development Grp	Washington D.C.	District of Columbia	20037	Recruiting
Encore Medical Research LLC	Hollywood	Florida	33024	Recruiting
NextPhase Research	Hollywood	Florida	33024	Recruiting
Jacksonville Ctr Clin Res	Jacksonville	Florida	32216	Not yet recruiting
PharmaDev Clinical Research Institute LLC	Miami	Florida	33176	Recruiting
South Broward Research LLC	Miramar	Florida	33027	Recruiting
Essence MD Research	Naples	Florida	34102	Not yet recruiting
Florida Inst For Clin Res LLC	Orlando	Florida	32825	Recruiting
Oviedo Medical Research, LLC	Oviedo	Florida	32765	Recruiting
Palm Beach Research Center	West Palm Beach	Florida	33409	Recruiting
Encore Medical Research of Weston	Weston	Florida	33331	Recruiting
Conquest Research	Atlanta	Georgia	30328	Recruiting
Eastside Bariatric and Gen Surg	Snellville	Georgia	30078	Recruiting
Chicago Research Center, Inc	Chicago	Illinois	60634	Not yet recruiting
Endeavor Health	Skokie	Illinois	60077	Recruiting
Midwest Inst For Clin Res	Indianapolis	Indiana	46260	Recruiting
Southern Clin Research	Zachary	Louisiana	70791	Not yet recruiting
Amicis Centers of Clinical Research	St Louis	Missouri	63128	Recruiting
Ichor Research	Syracuse	New York	13210	Recruiting
Southgate Medical Group, LLP	West Seneca	New York	14224	Recruiting
PharmQuest Life Sciences LLC	Greensboro	North Carolina	27408	Not yet recruiting
Piedmont Healthcare/Research	Statesville	North Carolina	28625	Recruiting
Lillestol Research LLC	Fargo	North Dakota	58104	Recruiting
Geisinger Clinic	Danville	Pennsylvania	17822	Recruiting
Medical University Of South Carolina	Charleston	South Carolina	29425	Recruiting
Hillcrest Clinical Research	Simpsonville	South Carolina	29681-1538	Recruiting
Spartanburg Medical Research	Spartanburg	South Carolina	29303	Recruiting
Amarillo Med Spec LLP	Amarillo	Texas	79124	Recruiting
Texas Diabetes & Endocrinology	Austin	Texas	78749	Recruiting
Pinnacle Clinical Research	Brownsville	Texas	78520	Recruiting
Osvaldo A. Brusco MD	Corpus Christi	Texas	78414	Recruiting
UT Southwestern Med Center	Dallas	Texas	75390	Not yet recruiting
Epic Medical Research	DeSoto	Texas	75115	Not yet recruiting
Houston Research Institute	Houston	Texas	77079	Not yet recruiting
The Endocrine Center	Houston	Texas	77079	Not yet recruiting
Sleep Therapy Research Center	San Antonio	Texas	78229	Not yet recruiting
Olympus Clinical Research	Sugar Land	Texas	77478	Not yet recruiting
National Clin Res Inc.	Richmond	Virginia	23294	Recruiting
Gastroent Consult of SW VA	Roanoke	Virginia	24014	Not yet recruiting
Rainier Clin Res Ctr Inc	Renton	Washington	98057	Recruiting
Seattle Clinical Research Center	Seattle	Washington	98104	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07668414, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 28, 2026 · Synced Oct 25, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07668414 live on ClinicalTrials.gov.

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