Evaluation of YB-101 for Safety, Tolerability, Pharmacokinetics, and Efficacy in Graves' Disease
Public ClinicalTrials.gov record NCT07682896. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Blinded, Placebo-Controlled, Two-Part, Phase 2 Study to Assess Safety, Tolerability, Pharmacokinetics, and Efficacy of YB-101 in Participants With Graves' Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is being conducted to look at the effect YB-101 has on thyroid function. This study will also evaluate how safe and well tolerated YB-101 is and how it is distributed through the body. The study consists of a part 1, blinded treatment period, and a part 2 double-blinded treatment period. Participants will receive YB-101 or Placebo subcutaneously. Participants who participate in Part 1 can not participate in Part 2. Participants will complete 34-39 in-clinic visits in Part 1 or Part 2 over an approximate 40 week period.
Study identification
- NCT ID
- NCT07682896
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 232 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 9, 2026
- Primary completion
- Nov 30, 2027
- Completion
- Aug 31, 2029
- Last update posted
- Sep 3, 2026
2026 – 2029
United States locations
- U.S. sites
- 28
- U.S. states
- 11
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Site 112 | Gilbert | Arizona | 85297 | Recruiting |
| Site 130 | Phoenix | Arizona | 85006 | Not yet recruiting |
| Clinical Research Site | Tucson | Arizona | 85710 | Not yet recruiting |
| Site 121 | La Mesa | California | 91942 | Recruiting |
| Site 103 | Sacramento | California | 95817 | Not yet recruiting |
| Site 111 | San Francisco | California | 94143 | Not yet recruiting |
| Site 105 | Torrance | California | 90502 | Not yet recruiting |
| Site 109 | Miami Lakes | Florida | 33016 | Recruiting |
| Site 115 | Palm Harbor | Florida | 34684 | Recruiting |
| Site 123 | Sarasota | Florida | 34239 | Not yet recruiting |
| Site 118 | Macon | Georgia | 31210 | Recruiting |
| Site 122 | Bowling Green | Kentucky | 42103 | Recruiting |
| Site 126 | Flint | Michigan | 48532 | Recruiting |
| Site 107 | Livonia | Michigan | 48152 | Recruiting |
| Site 108 | Omaha | Nebraska | 68198 | Not yet recruiting |
| Site 129 | Niagara Falls | New York | 14304 | Recruiting |
| Site 120 | Orchard Park | New York | 14127 | Recruiting |
| Clinical Research Site | Raleigh | North Carolina | 27612 | Not yet recruiting |
| Site 124 | Sayre | Pennsylvania | 18840 | Not yet recruiting |
| Site 100 | Amarillo | Texas | 79124 | Recruiting |
| Site 117 | Conroe | Texas | 77384 | Recruiting |
| Clinical Research Site | Dallas | Texas | 75246 | Not yet recruiting |
| Site 128 | Edinburg | Texas | 78539 | Recruiting |
| Site 127 | El Paso | Texas | 79935 | Not yet recruiting |
| Site 106 | Fort Worth | Texas | 76132 | Recruiting |
| Site 110 | Houston | Texas | 77095 | Recruiting |
| Site 101 | Humble | Texas | 77346 | Recruiting |
| Site 116 | San Antonio | Texas | 78233 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07682896, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 3, 2026 · Synced Sep 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07682896 live on ClinicalTrials.gov.