Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)

ClinicalTrials.gov ID: NCT07684235

Public ClinicalTrials.gov record NCT07684235. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 4, 2026, 2:00 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-Blind Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide in Participants With Obesity or Overweight

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The primary objective of this trial is to evaluate the long-term efficacy, safety, and tolerability of maridebart cafraglutide in participants with obesity or overweight. Trial 20250197 is an extension of trial 20210181 (NCT06858839).

Study identification

NCT ID: NCT07684235
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Amgen; Industry
Enrollment: 3,200 participants

Conditions and interventions

Conditions

Interventions

Maridebart cafraglutide Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 99 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 22, 2026
Primary completion: Dec 25, 2027
Completion: Mar 18, 2028
Last update posted: Sep 2, 2026

2026 – 2028

United States locations

U.S. sites: 70
U.S. states: 27
U.S. cities: 60

Facility	City	State	ZIP	Site status
Pinnacle Research Group LLC	Anniston	Alabama	36207	Recruiting
Alliance For Multispecialty Research - Daphne	Daphne	Alabama	36526	Recruiting
Alliance for Multispecialty Research Mobile	Mobile	Alabama	36608	Recruiting
Ark Clinical Research- Tustin	Fountain Valley	California	92708	Recruiting
Long Beach Clinical Trials Services Inc	Long Beach	California	90806	Recruiting
Ark Clinical Research- Long Beach	Long Beach	California	90815	Recruiting
Catalina Research Institute	Montclair	California	91763	Recruiting
Artemis Institute for Clinical Research	Riverside	California	92503	Recruiting
Apex Clinical Research	San Diego	California	92120	Recruiting
Artemis Institute for Clinical Research	San Diego	California	92123	Recruiting
Southern California Clinical Research	Santa Ana	California	92701	Recruiting
Diablo Clinical Research	Walnut Creek	California	94598	Recruiting
Chase Medical Research LLC	Waterbury	Connecticut	06708	Recruiting
Jacksonville Center for Clinical Research	Jacksonville	Florida	32216	Recruiting
Clinical Neuroscience Solutions - Jacksonville	Jacksonville	Florida	32256	Recruiting
South Florida Wellness and Clinical Research Institute	Margate	Florida	33063	Recruiting
Optimus U Corporation	Miami	Florida	33135	Recruiting
Research Institute of South Florida	Miami	Florida	33173	Recruiting
Indago Research and Health Center	Miami Lakes	Florida	33016	Recruiting
Renstar Medical Research	Ocala	Florida	34470	Recruiting
Clinical Neuroscience Solutions - Orlando	Orlando	Florida	32801	Recruiting
Combined Research Orlando Phase I IV	Orlando	Florida	32807	Recruiting
Florida Institute for Clinical Research	Orlando	Florida	32825	Recruiting
Encore Medical Research of Weston LLC	Weston	Florida	33331	Recruiting
Center for Advanced Research and Education	Gainesville	Georgia	30501	Recruiting
Rophe Adult and Pediatric Medicine/Sky Clinical Research Network Group	Union City	Georgia	30291	Recruiting
East-West Medical Research	Honolulu	Hawaii	96814	Recruiting
Solaris Clinical Research	Meridian	Idaho	83646	Recruiting
Flourish Research - Great Lakes Clinical Trials	Chicago	Illinois	60640	Recruiting
Endeavor Health	Skokie	Illinois	60077	Recruiting
Evanston Premier Healthcare Research LLC	Skokie	Illinois	60077	Recruiting
Alliance for Multispecialty Research Newton	Newton	Kansas	67114	Recruiting
Monroe Biomedical Research	Louisville	Kentucky	40213	Recruiting
Velocity Clinical Research - Baton Rouge	Baton Rouge	Louisiana	70809	Recruiting
Tandem Clinical Research - Marrero	Marrero	Louisiana	70072	Recruiting
Headlands Research - Detroit	Southfield	Michigan	48034	Recruiting
Prime Health and Wellness Sky Clinical Research Network Group	Fayette	Mississippi	39069	Recruiting
Alliance for Multispecialty Research - Kansas City	Kansas City	Missouri	64114	Recruiting
Palm Research Center Inc	Las Vegas	Nevada	89128	Recruiting
Vector Clinical Trials	Las Vegas	Nevada	89128	Recruiting
Velocity Clinical Research- Binghamton	Binghamton	New York	13905	Recruiting
Rochester Clinical Research	Rochester	New York	14609	Recruiting
Accellacare of Hickory	Hickory	North Carolina	28601	Recruiting
Carolina Research Center Inc	Shelby	North Carolina	28150	Recruiting
Clinical Trial Investigator Clinical Research Center	Cincinnati	Ohio	45212	Recruiting
Velocity Clinical Research - Cincinnati	Cincinnati	Ohio	45219	Recruiting
Alliance for Multispecialty Research - Norman	Norman	Oklahoma	73069	Recruiting
Capital Area Research LLC	Newport	Pennsylvania	17074	Recruiting
Velocity Clinical Research - Providence	East Greenwich	Rhode Island	02818	Recruiting
Tribe Clinical Research LLC Dba Mountain View Clinical Research	Greenville	South Carolina	29607	Recruiting
New Phase Research and Development	Knoxville	Tennessee	37909	Recruiting
Elligo Clinical Research Center	Austin	Texas	78704	Recruiting
Johnson County Clinical Trials Juno Bellaire	Bellaire	Texas	77401	Recruiting
Cedar Health Research, LLC	Dallas	Texas	75251	Recruiting
Epic Medical Research - Red Oak	DeSoto	Texas	75115	Recruiting
Great Lakes Research Institute El Paso Research	El Paso	Texas	79936	Recruiting
Cedar Health Research, LLC	Euless	Texas	76040	Recruiting
JCCT- Juno Northwest Houston	Houston	Texas	77040	Recruiting
Biopharma Informatic, LLC	Houston	Texas	77043	Recruiting
Southern Endocrinology Associates PA	Mesquite	Texas	75149	Recruiting
Great Lakes Research Institute - McAllen Research	Pharr	Texas	78557	Recruiting
Clinical Trials of Texas	San Antonio	Texas	78229	Recruiting
Sugar Lakes Family Practice	Sugar Land	Texas	77479	Recruiting
Pantheon Clinical Research	Bountiful	Utah	84010	Recruiting
Alliance for Multispecialty Research Layton Research Center	Layton	Utah	84041	Recruiting
Chrysalis Clinical Research, LLC	St. George	Utah	84770	Recruiting
Washington Center for Weight Management and Research, Inc	Arlington	Virginia	22206	Recruiting
Health Research of Hampton Roads	Newport News	Virginia	23606	Recruiting
Selma Medical Associates	Winchester	Virginia	22601	Recruiting
Allegiance Research Specialists	Wauwatosa	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07684235, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 2, 2026 · Synced Sep 4, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07684235 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →