A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)
Public ClinicalTrials.gov record NCT07705555. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Masked, Multicenter, 3-Arm, Pivotal Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) MK-8748 Compared With Aflibercept (2 mg) in Participants With Diabetic Macular Edema (DME)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Researchers are looking for new ways to treat diabetic macular edema (DME). In this trial, researchers want to learn if a trial medicine called MK-8748 can treat DME. An available standard (usual) treatment for DME is aflibercept. However, standard treatments such as aflibercept may not work for every person. The main goal of this trial is to learn if MK-8748 works as well as aflibercept to treat DME.
Study identification
- NCT ID
- NCT07705555
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 960 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 27, 2026 (Actual)
- Primary completion
- Oct 31, 2028 (Estimated)
- Completion
- Oct 31, 2029 (Estimated)
- Last update posted
- Oct 20, 2026
2026 – 2029
United States locations
- U.S. sites
- 24
- U.S. states
- 14
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Global Research Management ( Site 0066) | Glendale | California | 91204 | Recruiting |
| Retinal Consultants Medical Group ( Site 0013) | Sacramento | California | 95825 | Recruiting |
| Retina Specialists of Colorado ( Site 0068) | Denver | Colorado | 80222 | Recruiting |
| Retina Consultants ( Site 0065) | Manchester | Connecticut | 06042 | Recruiting |
| Vitreo Retinal Associates ( Site 0042) | Gainesville | Florida | 32607 | Recruiting |
| Retina Care Specialists ( Site 0095) | Palm Beach Gardens | Florida | 33410 | Recruiting |
| Retina Vitreous Associates of Florida ( Site 0034) | Tampa | Florida | 33617 | Recruiting |
| Retina Associates LLC ( Site 0024) | Lenexa | Kansas | 66215 | Recruiting |
| Mid Atlantic Retina ( Site 0062) | Hagerstown | Maryland | 21740 | Recruiting |
| Retina Specialists ( Site 0074) | Towson | Maryland | 21204 | Recruiting |
| Mississippi Retina Associates, P.A. ( Site 0061) | Madison | Mississippi | 39110 | Recruiting |
| Envision Ocular, LLC ( Site 0039) | Bloomfield | New Jersey | 07003 | Recruiting |
| Retina Associates of Western NY, PC ( Site 0038) | Rochester | New York | 14620 | Recruiting |
| North Carolina Retina Associates ( Site 0064) | Wake Forest | North Carolina | 27587 | Recruiting |
| Charleston Neuroscience Institute ( Site 0087) | Bluffton | South Carolina | 29910 | Recruiting |
| Palmetto Retina Center ( Site 0063) | Florence | South Carolina | 29501 | Recruiting |
| Palmetto Retina Center ( Site 0014) | West Columbia | South Carolina | 29169 | Recruiting |
| Southeastern Retina Associates PC ( Site 0071) | Johnson City | Tennessee | 37604 | Recruiting |
| Southeastern Retina Associates PC ( Site 0018) | Knoxville | Tennessee | 37922-3572 | Recruiting |
| Austin Retina Associates ( Site 0008) | Austin | Texas | 78705 | Recruiting |
| Retina Consultants of Texas ( Site 0001) | Bellaire | Texas | 77401 | Recruiting |
| Austin Retina Associates ( Site 0080) | San Marcos | Texas | 78666 | Recruiting |
| Retina Consultants of Texas ( Site 0029) | Schertz | Texas | 78154 | Recruiting |
| Retina Consultants ( Site 0104) | Charleston | West Virginia | 25301 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07705555, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 20, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07705555 live on ClinicalTrials.gov.