A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005)
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This page only displays public information reproduced from the official ClinicalTrials.gov record NCT07705607. It adds no medical advice, opinions, or eligibility judgments. The official record remains the source of truth for eligibility criteria, enrollment, and contact information.
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Official title
A Randomized, Double-Masked, Multicenter, 3-Arm, Pivotal Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal (IVT) MK-8748 Compared With Aflibercept (2 mg) in Participants With Diabetic Macular Edema (DME)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Researchers are looking for new ways to treat diabetic macular edema (DME). In this trial, researchers want to learn if a trial medicine called MK-8748 can treat DME. An available standard (usual) treatment for DME is aflibercept. However, standard treatments such as aflibercept may not work for every person. The main goal of this trial is to learn if MK-8748 works as well as aflibercept to treat DME.
Study identification
- NCT ID
- NCT07705607
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,104 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 25, 2026 (Actual)
- Primary completion
- Nov 30, 2028 (Estimated)
- Completion
- Nov 30, 2029 (Estimated)
- Last update posted
- Nov 12, 2026
2026 – 2029
United States locations
- U.S. sites
- 26
- U.S. states
- 11
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants, Ltd ( Site 0082) | Phoenix | Arizona | 85020 | Recruiting |
| California Retina Consultants ( Site 0023) | Bakersfield | California | 93309 | Recruiting |
| Retina-Vitreous Associates Medical Group ( Site 0124) | Beverly Hills | California | 90211 | Recruiting |
| South Coast Retina Center ( Site 0121) | Long Beach | California | 90807 | Recruiting |
| Retinal Consultants Medical Group ( Site 0017) | Modesto | California | 95356 | Recruiting |
| Retinal Consultants Medical Group ( Site 0015) | Sacramento | California | 95841 | Recruiting |
| Retina Group of New England ( Site 0101) | Waterford | Connecticut | 06385 | Recruiting |
| Florida Retina Institute ( Site 0035) | Orlando | Florida | 32806 | Recruiting |
| Retina Vitreous Associates of Florida ( Site 0036) | St. Petersburg | Florida | 33711 | Recruiting |
| Center for Retina and Macular Disease ( Site 0047) | Winter Haven | Florida | 33880 | Recruiting |
| Associated Vitreoretinal and Uveitis Consultants ( Site 0099) | Carmel | Indiana | 46032 | Recruiting |
| Wolfe Eye Clinic ( Site 0044) | West Des Moines | Iowa | 50266 | Recruiting |
| Cumberland Valley Retina Consultants ( Site 0003) | Hagerstown | Maryland | 21740 | Recruiting |
| Retina-Vitreous Surgeons of Central NY ( Site 0021) | Liverpool | New York | 13088 | Recruiting |
| North Carolina Retina Associates ( Site 0122) | Greenville | North Carolina | 27834 | Recruiting |
| Graystone Eye ( Site 0059) | Hickory | North Carolina | 28602 | Recruiting |
| Piedmont Retina Specialists ( Site 0049) | Winston-Salem | North Carolina | 27103 | Recruiting |
| Palmetto Retina Center ( Site 0073) | Aiken | South Carolina | 29801 | Recruiting |
| Charleston Neuroscience Institute ( Site 0090) | Beaufort | South Carolina | 29902 | Recruiting |
| Charleston Neuroscience Institute ( Site 0076) | Charleston | South Carolina | 29414 | Recruiting |
| Retina Consultants of South Carolina ( Site 0026) | Ladson | South Carolina | 29456 | Recruiting |
| Texas Retina ( Site 0051) | Arlington | Texas | 76012 | Recruiting |
| Texas Retina Associates ( Site 0055) | Fort Worth | Texas | 76104 | Recruiting |
| Retina Consultants of Texas - Katy/Cinco Ranch ( Site 0100) | Katy | Texas | 77494 | Recruiting |
| Retina Consultants of Texas ( Site 0005) | San Antonio | Texas | 78240 | Recruiting |
| Retina Center of Texas ( Site 0096) | Southlake | Texas | 76092 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07705607, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 12, 2026 · Synced Nov 14, 2026
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