A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age
Public ClinicalTrials.gov record NCT07742644. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3a, Observer-blind, Randomized, Controlled Study to Demonstrate Lot-to-lot Consistency and Evaluate the Immunogenicity and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine Compared With ProQuad, Administered as a Second Dose in Healthy Children 4-6 Years of Age
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate how consistently 3 different manufacturing lots of the GSK's investigational measles, mumps, rubella, and varicella (MMRVNS) vaccine will produce an immune response. It will also compare the overall immune response to the MMRVNS vaccine with that of the Merck licensed measles, mumps, rubella, and varicella (MMRV) vaccine. The vaccines will be given as a second dose to children aged 4 to 6 years who have previously received a first dose of any combination of measles, mumps, rubella, and varicella-containing vaccine(s). The study will also assess the immune response and safety of the MMRVNS and MMRV vaccines when given at the same time as a diphtheria, tetanus, acellular pertussis, and inactivated poliovirus (DTaP-IPV) vaccine. The DTaP-IPV vaccine used is licensed as Kinrix in the United States.
Study identification
- NCT ID
- NCT07742644
- Recruitment status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,860 participants
Conditions and interventions
Interventions
- MMRVNS vaccine Biological
- MMRV vaccine Biological
- DTaP-IPV vaccine Biological
Biological
Eligibility (public fields only)
- Age range
- 4 Years to 6 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 11, 2026 (Estimated)
- Primary completion
- Jun 27, 2028 (Estimated)
- Completion
- Nov 21, 2028 (Estimated)
- Last update posted
- Aug 3, 2026
2026 – 2028
United States locations
- U.S. sites
- 38
- U.S. states
- 18
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's Clinic of Jonesboro, AR | Jonesboro | Arkansas | 72401 | — |
| Applied Research Center of Arkansas | Little Rock | Arkansas | 72212 | — |
| Century Research Institute Inc | Huntington Park | California | 90255 | — |
| Matrix Clinical Research | Los Angeles | California | 90057 | — |
| Center for Clinical Trials of Sacramento, Inc. | Sacramento | California | 95823 | — |
| Center for Clinical Trials of San Gabriel | West Covina | California | 91790 | — |
| BioMD Clinical Research | Coral Gables | Florida | 33134 | — |
| D&H Pompano Research Center LLC | Margate | Florida | 33063 | — |
| PAS Research | Tampa | Florida | 33613 | — |
| Medical Research Partners | Ammon | Idaho | 83406 | — |
| Ann & Robert H. Lurie Children's Hospital of Chicago | Chicago | Illinois | 60611-2605 | — |
| Kentucky Pediatric/ Adult Research | Bardstown | Kentucky | 40004 | — |
| Norton Childrens Research Institute | Louisville | Kentucky | 40202 | — |
| Benchmark Research | Covington | Louisiana | 70433 | — |
| ACC Pediatric Research | Haughton | Louisiana | 71037 | — |
| Velocity Clinical Research, Gulfport | Lafayette | Louisiana | 70508 | — |
| Jefferson City Medical Group PC | Jefferson City | Missouri | 65109 | — |
| Boeson Research MSO | Missoula | Montana | 59804 | — |
| Midwest Children's Health Research Institute, LLC | Lincoln | Nebraska | 68504 | — |
| Midwest Children's Health Research Institute, LLC | Lincoln | Nebraska | 68505 | — |
| Complete Children's Health | Lincoln | Nebraska | 68516 | — |
| Complete Children's Health | Lincoln | Nebraska | 68522-1231 | — |
| Atrium Health | Charlotte | North Carolina | 28203 | — |
| Senders Pediatrics | Cleveland | Ohio | 44121-4243 | — |
| Neighbors Clinical Research | Charleston | South Carolina | 29407 | — |
| Tribe Clinical Research LLC/Parkside Pediatrics | Greenville | South Carolina | 29607 | — |
| Tribe Clinical Research LLC/Parkside Pediatrics | Simpsonville | South Carolina | 29681 | — |
| Carolina Family Care | Summerville | South Carolina | 29486 | — |
| Meharry Medical College | Nashville | Tennessee | 37208 | — |
| Tekton Research - Beaumont, TX | Beaumont | Texas | 77706 | — |
| Pas Research | Edinburg | Texas | 78539 | — |
| Pediatric Associates | Houston | Texas | 77087 | — |
| Tanner Clinic Kaysville | Kaysville | Utah | 84037 | — |
| Tanner Clinic Layton Parkway | Layton | Utah | 84041 | — |
| Ogden Clinic Canyon View | Ogden | Utah | 84404 | — |
| Pediatric Research of Charlottesville, LLC | Charlottesville | Virginia | 22902 | — |
| Clinical Research Partners, LLC | Richmond | Virginia | 23236 | — |
| Marshfield Clinic Research Foundation, a Division of Marshfield Clinic, Inc | Marshfield | Wisconsin | 54449 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 24 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07742644, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 3, 2026 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07742644 live on ClinicalTrials.gov.