A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma
Public ClinicalTrials.gov record NCT07768189. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, 2-Arm Study to Evaluate the Efficacy and Safety of CRB-701 Compared With Investigator's Choice of Capecitabine, Cetuximab, or Docetaxel in Participants With Recurrent or Metastatic Oropharyngeal Squamous Cell Carcinoma Previously Treated With Platinum-based Chemotherapy and a PD-(L)1 Inhibitor
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this study is to understand whether CRB-701, a targeted form of chemotherapy called an anti-body drug conjugate, will work as a treatment for oropharyngeal (throat, tonsil) cancer. In patients who have already received platinum based chemotherapy or immunotherapy (using a check-point inhibitor) It will also learn about the safety of the drug and measure quality of life. The main questions it asks are: * What proportion of participants respond to CRB-701 measured using scans (CT or MRI) * What medical problems do participants experience when taking CRB-701. Researchers will compare CRB-701 with standard of care medicines (drugs that are normally used this disease). Participants will: * Attend clinic every three weeks to receive infusions of CRB-701 or standard of care medicines until the cancer cannot be measured or is not controlled by the treatment they are receiving. * Have a CT or MRI every 6 weeks to measure the effect on their cancer * Complete questionnaires to assess their health status.
Study identification
- NCT ID
- NCT07768189
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 260 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 29, 2026 (Actual)
- Primary completion
- Dec 2027 (Estimated)
- Completion
- Mar 2029 (Estimated)
- Last update posted
- Oct 8, 2026
2026 – 2029
United States locations
- U.S. sites
- 38
- U.S. states
- 24
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clearview Cancer Institute | Huntsville | Alabama | 38505 | Not yet recruiting |
| The University of Arizona Cancer Center | Tucson | Arizona | 85719 | Not yet recruiting |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | Not yet recruiting |
| University of California Los Angeles Westwood Cancer Center | Los Angeles | California | 90095 | Not yet recruiting |
| Stanford Medicine - Cancer Center | Palo Alto | California | 94304 | Not yet recruiting |
| Moores Cancer Center | San Diego | California | 92037 | Not yet recruiting |
| UCSF Head and Neck Surgery Cancer Program | San Francisco | California | 94158 | Not yet recruiting |
| UCHealth Cancer Care - Anschutz Medical Campus - University of Colorado | Colorado Springs | Colorado | 80920 | Not yet recruiting |
| Yale School of Medicine | Newhaven | Connecticut | 06510 | Not yet recruiting |
| Medical Oncology Hematology Consultants | Newark | Delaware | 19713 | Not yet recruiting |
| Florida Cancer Specialists and Research Institute | Orlando | Florida | 32827 | Recruiting |
| Moffitt Cancer Center Magnolia Campus | Tampa | Florida | 33612 | Not yet recruiting |
| University of Chicago | Chicago | Illinois | 60637 | Not yet recruiting |
| Iowa Health Care Holden Comprehensive Cancer Center | Iowa City | Iowa | 52242 | Not yet recruiting |
| University of Louisville Health | Louisville | Kentucky | 40202 | Not yet recruiting |
| University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | Not yet recruiting |
| Greater Baltimore Medical Center | Baltimore | Maryland | 21204 | Not yet recruiting |
| Dana Faber Cancer Institute | Boston | Massachusetts | 02215 | Not yet recruiting |
| Barbara Ann Karmanos Cancer Institute - Wayne State University | Detroit | Michigan | 48201 | Not yet recruiting |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55059 | Not yet recruiting |
| Washington University in St. Louis | St Louis | Missouri | 63130 | Not yet recruiting |
| Nebraska Cancer Specialists - Methodist Estabrook Cancer Center | Omaha | Nebraska | 68130 | Recruiting |
| NYU Langone Health Perlmutter Cancer Center | New York | New York | 10016 | Not yet recruiting |
| Memorial Sloan Kettering | New York | New York | 10021 | Not yet recruiting |
| Gabrail Cancer Center and Research Center | Canton | Ohio | 44718 | Recruiting |
| Cleveland Clinic Main Campus | Cleveland | Ohio | 44195 | Not yet recruiting |
| The Ohio State University Comprehensive Cancer Center The Arthur G.James | Columbus | Ohio | 43210 | Not yet recruiting |
| Penn-Medicine - Abramson Cancer Center University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | Not yet recruiting |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | Not yet recruiting |
| MUSC Hollings Cancer Center | Charleston | South Carolina | 29425 | Not yet recruiting |
| Prisma Health Cancer Institute Multidisciplinary Center | Greenville | South Carolina | 29605 | Not yet recruiting |
| Tennessee Cancer Specialists | Knoxville | Tennessee | 37919 | Not yet recruiting |
| Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | 37232 | Not yet recruiting |
| Texas Oncology | Austin | Texas | 78745 | Not yet recruiting |
| Texas Oncology | Dallas | Texas | 75246 | Not yet recruiting |
| UVA Health - Emily Couric Clinical Cancer Center | Charlottesville | Virginia | 22908 | Not yet recruiting |
| Fred Hutchinson Cancer Center Clinical - Seattle Cancer Care Alliance | Seattle | Washington | 98109-1024 | Not yet recruiting |
| Northwest Cancer Center | Vancouver | Washington | 98684 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 73 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07768189, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2026 · Synced Oct 16, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07768189 live on ClinicalTrials.gov.