Prospective Natural History Study of POLG Disease
Public ClinicalTrials.gov record NCT07775872. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Global Prospective Natural History Study of POLG Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The PIONEER study is a prospective, natural history study dedicated to characterizing the clinical progression of POLG-related disorders. The research aims to bridge the gap between genetic diagnosis and drug development by mapping how these rare mitochondrial conditions evolve over time. By observing the disease's natural trajectory through a multi-center approach, The study identifies critical clinical milestones that serve as a foundation for evaluating therapeutic efficacy and future therapeutic interventions
Study identification
- NCT ID
- NCT07775872
- Recruitment status
- Recruiting
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 300 participants
Conditions and interventions
Conditions
Interventions
Not listed
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 17, 2026 (Actual)
- Primary completion
- Jun 17, 2029 (Estimated)
- Completion
- Jun 17, 2031 (Estimated)
- Last update posted
- Sep 15, 2026
2026 – 2031
United States locations
- U.S. sites
- 7
- U.S. states
- 6
- U.S. cities
- 7
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of California San Diego | San Diego | California | 92121 | Not yet recruiting |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | Not yet recruiting |
| Columbia University Irving Medical Center | New York | New York | 10032 | Not yet recruiting |
| Akron Children's Hospital | Akron | Ohio | 44308 | Not yet recruiting |
| Children's Hospital of Philadelphia-Philadelphia | Philadelphia | Pennsylvania | 19104 | Not yet recruiting |
| Baylor Hospital | Dallas | Texas | 75246 | Not yet recruiting |
| UTHealth Houston | Houston | Texas | 77030 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07775872, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 15, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07775872 live on ClinicalTrials.gov.