A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes Mellitus

ClinicalTrials.gov ID: NCT07776509

Public ClinicalTrials.gov record NCT07776509. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 16, 2026, 10:48 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III Randomised, Double-Blind, Placebo-Controlled Multicentre Trial to Evaluate the Efficacy and Safety of AZD6234 as an Adjunct to Incretin-based Therapies in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity With or Without Type 2 Diabetes Mellitus (SELENE 3)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The study will evaluate how well AZD6234 works and how safe it is in adults with excess weight or obesity. Efficacy of AZD6234 will be compared to placebo in percent body weight change from baseline at 68 weeks of treatment.

Study identification

NCT ID: NCT07776509
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: AstraZeneca; Industry
Enrollment: 500 participants

Conditions and interventions

Conditions

Interventions

Lenbelintide Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 24, 2026 (Actual)
Primary completion: Aug 9, 2028 (Estimated)
Completion: Aug 9, 2028 (Estimated)
Last update posted: Sep 25, 2026

2026 – 2028

United States locations

U.S. sites: 23
U.S. states: 17
U.S. cities: 22

Facility	City	State	ZIP	Site status
Research Site	Escondido	California	92025	Not yet recruiting
Research Site	Lincoln	California	95648	Recruiting
Research Site	Walnut Creek	California	94598	Not yet recruiting
Research Site	Jacksonville	Florida	32204	Not yet recruiting
Research Site	Jacksonville	Florida	32205	Not yet recruiting
Research Site	Stockbridge	Georgia	30281	Not yet recruiting
Research Site	Woodstock	Georgia	30189	Recruiting
Research Site	Champaign	Illinois	61822	Not yet recruiting
Research Site	Chicago	Illinois	60640	Not yet recruiting
Research Site	Beltsville	Maryland	20705	Not yet recruiting
Research Site	Oxon Hill	Maryland	20745	Not yet recruiting
Research Site	Kansas City	Missouri	64111	Not yet recruiting
Research Site	Las Vegas	Nevada	89101	Not yet recruiting
Research Site	Somerset	New Jersey	08873	Not yet recruiting
Research Site	Statesville	North Carolina	28625	Recruiting
Research Site	Fargo	North Dakota	58104	Recruiting
Research Site	Columbus	Ohio	43215	Not yet recruiting
Research Site	Portland	Oregon	97202	Not yet recruiting
Research Site	Smithfield	Pennsylvania	15478	Not yet recruiting
Research Site	Franklin	Tennessee	37067	Withdrawn
Research Site	Houston	Texas	77043	Recruiting
Research Site	Manassas	Virginia	20110	Not yet recruiting
Research Site	Renton	Washington	98057	Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 72 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07776509, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 25, 2026 · Synced Oct 16, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07776509 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →