Study to Assess Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at Multiple Dose Levels Adjuvanted With Matrix-M in Healthy Participants 18 Years of Age and Above.
Public ClinicalTrials.gov record NCT07779408. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2, Parallel, Observer-blind Study to Assess the Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at Multiple Dose Levels Adjuvanted With Matrix-M in Healthy Participants 18 Years of Age and Above.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study aims to evaluate an egg-based H5N8 influenza vaccine up to 3 dose levels (low, medium, and high dose) given with or without adjuvant to see if the adjuvant improves vaccine effectiveness. The study will enroll healthy adults aged 18 years and over. Participants will receive 2 injections in their arm of either one of the 3 dose levels of the study vaccine (low, medium, or high dose) with the adjuvant or the unadjuvanted vaccine (high dose). Study duration per participant: approximately 14 months (including screening visit).
Study identification
- NCT ID
- NCT07779408
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 640 participants
Conditions and interventions
Conditions
Interventions
- Flu H5 egg pandemic low dose vaccine, with adjuvant Biological
- Flu H5 Egg Pandemic medium dose vaccine, with adjuvant Biological
- Flu H5 Egg Pandemic high dose vaccine, with adjuvant Biological
- Flu H5 Egg Pandemic high dose vaccine, without adjuvant Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 2, 2026
- Primary completion
- Feb 21, 2028
- Completion
- Feb 21, 2028
- Last update posted
- Sep 14, 2026
2026 – 2028
United States locations
- U.S. sites
- 16
- U.S. states
- 11
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AMR Clinical Phoenix, Arizona- Site Number : 8400004 | Tempe | Arizona | 85281 | Recruiting |
| Peninsula Research Associates- Site Number : 8400011 | Rolling Hills Estates | California | 90274 | Recruiting |
| California Research Foundation- Site Number : 8400007 | San Diego | California | 92123 | Recruiting |
| Alliance for Multispeciality Research - Coral Gables- Site Number : 8400003 | Coral Gables | Florida | 33134 | Recruiting |
| Accel Research Sites Network - DeLand Clinical Research Unit- Site Number : 8400017 | DeLand | Florida | 32720 | Recruiting |
| Alliance for Multispeciality Research - Fort Myers- Site Number : 8400001 | Fort Myers | Florida | 33912 | Recruiting |
| Indago Research & Health Center- Site Number : 8400010 | Miami Lakes | Florida | 33016 | Recruiting |
| Accel Research Sites - NeuroStudies- Site Number : 8400014 | Decatur | Georgia | 30030 | Recruiting |
| iResearch Atlanta- Site Number : 8400008 | Decatur | Georgia | 30030 | Recruiting |
| AMR Chicago- Site Number : 8400005 | Oak Brook | Illinois | 60523 | Recruiting |
| AMR Clinical Newton, Kansas- Site Number : 8400006 | Newton | Kansas | 67114 | Recruiting |
| Rochester Clinical Research- Site Number : 8400012 | Rochester | New York | 14609 | Recruiting |
| Coastal Carolina Research Center - North Charleston- Site Number : 8400018 | North Charleston | South Carolina | 29405 | Recruiting |
| Alliance for Multispecialty Research - Weisgarber Medical Park- Site Number : 8400002 | Knoxville | Tennessee | 37909 | Recruiting |
| CenExel JRB - Salth Lake City- Site Number : 8400009 | Salt Lake City | Utah | 84107 | Recruiting |
| Charlottesville Medical Research- Site Number : 8400016 | Charlottesville | Virginia | 22911 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07779408, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 14, 2026 · Synced Sep 18, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07779408 live on ClinicalTrials.gov.