ClinicalTrials.gov record
A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity
ClinicalTrials.gov ID: NCT07794579
Public ClinicalTrials.gov record NCT07794579. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy and Safety of Once-Daily Oral Orforglipron Compared With Placebo in Individuals With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy and safety of orforglipron in participants with overweight and assess whether it helps reduce the future risk of obesity-related conditions, including type 2 diabetes, hypertension, and dyslipidemia, and progression to class 1 obesity.
Study identification
- NCT ID
- NCT07794579
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,001 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 26, 2026 (Actual)
- Primary completion
- Aug 2029 (Estimated)
- Completion
- Sep 2030 (Estimated)
- Last update posted
- Oct 8, 2026
2026 – 2030
United States locations
- U.S. sites
- 80
- U.S. states
- 31
- U.S. cities
- 76
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group, LLC | Anniston | Alabama | 36207 | Recruiting |
| Central Research Associates | Birmingham | Alabama | 35205 | Recruiting |
| Cahaba Research - Pelham | Pelham | Alabama | 35124 | Recruiting |
| Care Access - 801 South Power Road, Mesa | Mesa | Arizona | 85206 | Recruiting |
| Absolute Clinical Research | Phoenix | Arizona | 85051 | Not yet recruiting |
| Synexus Clinical Research US, Inc./Orange Grove Family Practice | Tucson | Arizona | 85741 | Recruiting |
| Orange County Research Center | Lake Forest | California | 92630 | Recruiting |
| Healthy Brain Clinic | Long Beach | California | 90804 | Recruiting |
| Los Angeles Institute for Metabolic Research | Los Angeles | California | 90015 | Recruiting |
| Desert Oasis Healthcare Medical Group | Palm Springs | California | 92262 | Recruiting |
| Artemis Institute for Clinical Research | Riverside | California | 92503 | Recruiting |
| Riverside Clinical | Riverside | California | 92506 | Recruiting |
| Headlands Research- Sacramento | Sacramento | California | 95821 | Recruiting |
| Norcal Endocrinology & Internal Medicine | San Ramon | California | 94583 | Recruiting |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | Recruiting |
| Yale University School of Medicine | New Haven | Connecticut | 06519 | Not yet recruiting |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | Recruiting |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | Recruiting |
| Flourish Research Acquisition, LLC dba Flourish Research - North Miami | Miami | Florida | 33138 | Recruiting |
| New Age Medical Research Corporation | Miami | Florida | 33186 | Recruiting |
| Renstar Medical Research | Ocala | Florida | 34471 | Recruiting |
| Headlands Research Orlando | Orlando | Florida | 32803 | Recruiting |
| Oviedo Medical Research | Oviedo | Florida | 32765 | Recruiting |
| Care Access - St. Petersburg | St. Petersburg | Florida | 33710 | Recruiting |
| Precision Clinical Research | Sunrise | Florida | 33351 | Recruiting |
| SKY Clinical Research Network Group-Brown | Atlanta | Georgia | 30331 | Recruiting |
| HOPE Clinical Research & Wellness | Conyers | Georgia | 30094 | Recruiting |
| Care Access - Dalton Walmart | Dalton | Georgia | 30720 | Recruiting |
| Care Access - Decatur | Decatur | Georgia | 30030 | Recruiting |
| Family First Medical Center | Idaho Falls | Idaho | 83404 | Recruiting |
| Solaris Clinical Research | Meridian | Idaho | 83646 | Recruiting |
| Great Lakes Clinical Trials - Ravenswood | Chicago | Illinois | 60640 | Recruiting |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50266 | Recruiting |
| Cotton O'Neil Clinical Research Center | Topeka | Kansas | 66606 | Not yet recruiting |
| Monroe Biomedical Research - Louisville | Louisville | Kentucky | 40213 | Not yet recruiting |
| Pennington Biomedical Research Center | Baton Rouge | Louisiana | 70808 | Recruiting |
| IMA Clinical Research Monroe-Main | Monroe | Louisiana | 71201 | Recruiting |
| Centennial Medical Group | Columbia | Maryland | 21045 | Recruiting |
| Brigham and Women's Hospital Diabetes Program | Boston | Massachusetts | 02115 | Recruiting |
| Great Lakes Research Group, Inc. | Bay City | Michigan | 48706 | Recruiting |
| Great Lakes Research Institute | Southfield | Michigan | 48075 | Recruiting |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | Not yet recruiting |
| Headlands Research-Twin Cities | Maplewood | Minnesota | 55109 | Recruiting |
| Clinvest Headlands Llc | Springfield | Missouri | 65807 | Recruiting |
| M3 Wake Research - Las Vegas Cimarron | Las Vegas | Nevada | 89113 | Recruiting |
| Renascor Clinical Research | Reno | Nevada | 89509 | Recruiting |
| IMA Clinical Research Warren | Warren Township | New Jersey | 07059 | Recruiting |
| Drug Trials America | Hartsdale | New York | 10530 | Recruiting |
| NYC Research INC | Long Island City | New York | 11106 | Not yet recruiting |
| Rochester Clinical Research, LLC | Rochester | New York | 14609 | Recruiting |
| Medication Management | Greensboro | North Carolina | 27401 | Recruiting |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | Not yet recruiting |
| West Clinical Research | Morehead City | North Carolina | 28557 | Recruiting |
| Trial Management Associates - Wilmington - Floral Parkway | Wilmington | North Carolina | 28403 | Recruiting |
| Lillestol Research | Fargo | North Dakota | 58104 | Recruiting |
| Remington-Davis, Inc | Columbus | Ohio | 43215 | Recruiting |
| Central States Research | Tulsa | Oklahoma | 74136 | Recruiting |
| The Corvallis Clinic, P.C. | Corvallis | Oregon | 97330 | Recruiting |
| Clinical Renal Associates Ltd. | Media | Pennsylvania | 19063 | Recruiting |
| Suburban Research Associates | West Chester | Pennsylvania | 19380 | Recruiting |
| Care Access - Mauldin | Mauldin | South Carolina | 29662 | Recruiting |
| New Phase Research and Development | Knoxville | Tennessee | 37909 | Recruiting |
| Clinical Research Associates Inc | Nashville | Tennessee | 37203 | Recruiting |
| IMA Clinical Research Austin | Austin | Texas | 78745 | Recruiting |
| Headlands Horizons, LLC dba Headlands Research-Brownsville | Brownsville | Texas | 78526 | Recruiting |
| Cedar Health Research - Texas Native Health | Dallas | Texas | 75235 | Recruiting |
| Headlands Research-El Paso | El Paso | Texas | 79902 | Recruiting |
| Cedar Health Research - Euless | Euless | Texas | 76040 | Recruiting |
| Biopharma Informatic, LLC | Houston | Texas | 77043 | Recruiting |
| Care Access - Houston - Clinical Trials Center by Walmart & Care Access | Houston | Texas | 77082 | Recruiting |
| Activian Clinical Research | Kingwood | Texas | 77339 | Not yet recruiting |
| DCOL Center for Clinical Research | Longview | Texas | 75605 | Recruiting |
| IMA Clinical Research San Antonio | San Antonio | Texas | 78229 | Recruiting |
| VIP Trials | San Antonio | Texas | 78230 | Not yet recruiting |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | Recruiting |
| Care Access - Tyler - Clinical Trials Center by Walmart & Care Access | Tyler | Texas | 75704 | Recruiting |
| Sovah Clinical Research-River District | Danville | Virginia | 24541 | Not yet recruiting |
| Clinical Research Partners, LLC | Richmond | Virginia | 23226 | Recruiting |
| CAMC Institute for Academic Medicine | Charleston | West Virginia | 25304 | Not yet recruiting |
| Frontier Clinical Research, LLC | Kingwood | West Virginia | 26537 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 100 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07794579, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07794579 live on ClinicalTrials.gov.