A Study to Assess the Safety, Tolerability, and Immunogenicity of 3 Lots of a Multivalent Pneumococcal Conjugate Vaccine Administered to Adults
Public ClinicalTrials.gov record NCT07794748. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3, RANDOMIZED, DOUBLE-BLIND TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF 3 LOTS OF A MULTIVALENT PNEUMOCOCCAL CONJUGATE VACCINE IN ADULTS
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to provide safety data and demonstrate lot consistency with the PG4 vaccine by evaluating the immunogenicity of 3 different lots of this vaccine. This study will compare a new pneumococcal vaccine with the vaccine currently in use to see if they are similarly safe. It will also compare three batches of the new vaccine to make sure they work the same way. Blood samples will be taken to measure how the body responds to the vaccines. The study will be conducted in the United States. Participants will be assigned to 1 of 4 groups. Group 1: PG4 vaccine lot 1; Group 2: PG4 vaccine lot 2; Group 3: PG4 vaccine lot 3; Group 4: 20vPnC. Within each group, participants will be assigned by chance in a 2:2:2:1 ratio to receive 1 vaccine injection (shot) with either PG4 (new vaccine) lot 1, PG4 lot 2, PG4 Lot 3 or 20vPnC, given in the arm. This means that for every 7 participants, about 2 will receive either PG4 lot 1, lot 2 or lot 3 and about 1 will receive 20vPnC. Each participant will take part in the study for approximately 6 months.
Study identification
- NCT ID
- NCT07794748
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 4,670 participants
Conditions and interventions
Conditions
Interventions
- PG4 Multivalent Vaccine Biological
- 20 Valent Pneumococcal Conjugate Vaccine (20vPnC) Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years to 49 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 8, 2026 (Actual)
- Primary completion
- Jun 7, 2027 (Estimated)
- Completion
- Jun 7, 2027 (Estimated)
- Last update posted
- Oct 14, 2026
2026 – 2027
United States locations
- U.S. sites
- 37
- U.S. states
- 18
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Achieve Clinical Research, LLC d/b/a Accel Research Sites - Birmingham Clinical Research Unit | Birmingham | Alabama | 35216 | Recruiting |
| Orange County Research Center | Lake Forest | California | 92630 | Recruiting |
| Diablo Clinical Research, LLC dba Flourish Research | Walnut Creek | California | 94598 | Recruiting |
| Clinical Research Consulting | Milford | Connecticut | 06460 | Recruiting |
| Suncoast Research Associates | Doral | Florida | 33172 | Recruiting |
| Research Centers of America | Hollywood | Florida | 33024 | Recruiting |
| East Coast Institute for Research, LLC | Jacksonville | Florida | 32216 | Recruiting |
| Entrust Clinical Research | Miami | Florida | 33176 | Recruiting |
| Palm Springs Community Health Center | Miami Lakes | Florida | 33014 | Recruiting |
| Indago Research and Health Center, Inc. | Miami Lakes | Florida | 33016 | Recruiting |
| Innovation Medical Research, LLC | Palmetto Bay | Florida | 33157 | Recruiting |
| Palm Beach Research Center | West Palm Beach | Florida | 33409 | Recruiting |
| Javara Inc. | Fayetteville | Georgia | 30214 | Recruiting |
| Clinical Research Atlanta | Stockbridge | Georgia | 30281 | Recruiting |
| East-West Medical Research Institute | Honolulu | Hawaii | 96814 | Recruiting |
| DM Clinical Research | Melrose Park | Illinois | 60160 | Recruiting |
| Velocity Clinical Research, Sioux City | Sioux City | Iowa | 51106 | Recruiting |
| Henry Ford St. John Hospital - Thomas Mackey Center for Infectious Disease Research | Grosse Pointe Woods | Michigan | 48236 | Recruiting |
| Clinical Research Professionals | Chesterfield | Missouri | 63005 | Recruiting |
| Bio-Kinetic Clinical Applications, LLC dba QPS-MO | Springfield | Missouri | 65802 | Recruiting |
| Bio-Kinetic Clinical Applications, LLC dba QPS-MO-Screening and Recruitment Center | Springfield | Missouri | 65807 | Recruiting |
| Sundance Clinical Research, LLC | St Louis | Missouri | 63141 | Recruiting |
| Velocity Clinical Research, Grand Island | Grand Island | Nebraska | 68803 | Recruiting |
| South Jersey Infectious Disease | Somers Point | New Jersey | 08244 | Recruiting |
| Accellacare - Wilmington | Wilmington | North Carolina | 28401 | Recruiting |
| Cincinnati Children's Hospital Medical Center Investigational Drug Services | Cincinnati | Ohio | 45206 | Recruiting |
| Cincinnati Children's Hospital Medical Center Vaccine Research Center | Cincinnati | Ohio | 45206 | Recruiting |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | Recruiting |
| DM Clinical Research | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Clinical Trials of South Carolina | Moncks Corner | South Carolina | 29461 | Recruiting |
| TMA Headlands LLC (d/b/a Trial Management Associates) | Myrtle Beach | South Carolina | 29572 | Recruiting |
| Coastal Carolina Research Center, LLC | North Charleston | South Carolina | 29405 | Recruiting |
| SMS Clinical Research LLC | Mesquite | Texas | 75149 | Recruiting |
| DM Clinical Research - Sugar Land | Sugar Land | Texas | 77478 | Recruiting |
| DM Clinical Research | Tomball | Texas | 77375 | Recruiting |
| J. Lewis Research, Inc. / Foothill Family Clinic | Salt Lake City | Utah | 84109 | Recruiting |
| J. Lewis Research, Inc. / Foothill Family Clinic South | Salt Lake City | Utah | 84121 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07794748, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 14, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07794748 live on ClinicalTrials.gov.