A Trial to Investigate PALI-2108 Versus Placebo in Participants With Moderately to Severely Active Ulcerative Colitis

ClinicalTrials.gov ID: NCT07845487

Public ClinicalTrials.gov record NCT07845487. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 4, 2026, 7:18 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Dose Ranging Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Induction and Maintenance Therapy With PALI-2108 in Participants With Moderately to Severely Active Ulcerative Colitis

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The ASCENTRA-UC study is a phase 2 study testing PALI-2108 in patients with moderate to severe ulcerative colitis. Doses of drug will be compared against a placebo to see how well it works, how safe it is, and how the body responds to it.

Study identification

NCT ID: NCT07845487
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Palisade Bio; Industry
Enrollment: 204 participants

Conditions and interventions

Conditions

Interventions

PALI-2108 Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 75 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 28, 2026 (Actual)
Primary completion: Oct 2027 (Estimated)
Completion: Jun 2028 (Estimated)
Last update posted: Sep 29, 2026

2026 – 2028

United States locations

U.S. sites: 30
U.S. states: 17
U.S. cities: 30

Facility	City	State	ZIP	Site status
Site US-022	Sun City	Arizona	85351	Recruiting
Site US-018	San Diego	California	92103	Not yet recruiting
Site US-028	Bristol	Connecticut	06010	Not yet recruiting
Site US-026	Orlando	Florida	32825	Recruiting
Site US-005	Des Plaines	Illinois	60016	Recruiting
Site US-007	Glenview	Illinois	60026	Recruiting
Site US-020	Gurnee	Illinois	60031	Recruiting
Site US-008	Baton Rouge	Louisiana	70809	Not yet recruiting
Site US-011	Mandeville	Louisiana	70471	Recruiting
Site US-010	Tupelo	Mississippi	38801	Not yet recruiting
Site US-006	St Louis	Missouri	63141	Recruiting
Site US-014	Clifton	New Jersey	07013	Recruiting
Site US-002	Albany	New York	12206	Recruiting
Site US-016	Rochester	New York	14618	Recruiting
Site US-025	Brunswick	Ohio	44212	Recruiting
Site US-023	Dayton	Ohio	45415	Recruiting
Site US-027	Westlake	Ohio	44145	Recruiting
Site US-019	Providence	Rhode Island	02905	Recruiting
Site US-003	Cordova	Tennessee	38018	Recruiting
Site US-024	Garland	Texas	75044	Recruiting
Site US-009	Georgetown	Texas	78628	Recruiting
Site US-030	Houston	Texas	77024	Recruiting
Site US-015	Lubbock	Texas	79424	Recruiting
Site US-017	Mansfield	Texas	760063	Recruiting
Site US-001	Southlake	Texas	76092	Recruiting
Site US-004	Tyler	Texas	75701	Not yet recruiting
Site US-013	Richmond	Virginia	23229	Recruiting
Site US-021	Bellevue	Washington	98004	Recruiting
Site US-029	Tacoma	Washington	98405	Recruiting
Site US-012	Milwaukee	Wisconsin	53215	Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 85 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07845487, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 29, 2026 · Synced Oct 4, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07845487 live on ClinicalTrials.gov.

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