ClinicalTrials.gov record
A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity
ClinicalTrials.gov ID: NCT07861100
Public ClinicalTrials.gov record NCT07861100. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Zenagamtide Use for the Reduction of Risk of Major Adverse Cardiovascular Events in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This clinical study is being conducted to evaluate the safety and effectiveness of zenagamtide in people with atherosclerotic cardiovascular disease (ASCVD) and excess body weight compared with placebo. The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have ASCVD and excess body weight. Participants will be randomly assigned by chance to receive either zenagamtide, the investigational treatment being tested, or a placebo, which contains no active medicine. Half of the participants will receive zenagamtide, and treatment assignment will be determined randomly. Zenagamtide is a new investigational medicine that is not yet available for prescription by doctors.
Study identification
- NCT ID
- NCT07861100
- Recruitment status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 8,500 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 45 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 26, 2026 (Estimated)
- Primary completion
- Sep 16, 2030 (Estimated)
- Completion
- Sep 16, 2030 (Estimated)
- Last update posted
- Oct 6, 2026
2026 – 2030
United States locations
- U.S. sites
- 155
- U.S. states
- 32
- U.S. cities
- 137
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Uni of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Eastern Shore Rsrch Inst, LLC | Fairhope | Alabama | 36532 | — |
| Mobile Heart Specialists | Mobile | Alabama | 36608 | — |
| Chambliss Clinical Trials LLC | Montgomery | Alabama | 36106 | — |
| Mercy Gilbert Medical Center | Gilbert | Arizona | 85297 | — |
| Sun City Clinical Research | Glendale | Arizona | 85304 | — |
| Honor Health | Scottsdale | Arizona | 85258 | — |
| Clinical Research Institute of Arizona | Surprise | Arizona | 85374 | — |
| National Heart Institute Cal | Beverly Hills | California | 90211 | — |
| California Inst Of Renal Res | Chula Vista | California | 91910 | — |
| Valley Clinical Trials | Covina | California | 91723 | — |
| First Valley Medical Group | Lancaster | California | 93534 | — |
| Torrance Clin Res Inst, Inc. | Lomita | California | 90717 | — |
| Pacific Clinical Studies | Los Alamitos | California | 90720 | — |
| Academic Medical Research Institute | Los Angeles | California | 90022 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Desert Oasis Hlthcr Med Group | Palm Springs | California | 92262 | — |
| Clinical Trials Research_Sacramento | Sacramento | California | 95821 | — |
| Paradigm Clinical Research | San Diego | California | 92108 | — |
| N America Res Inst - San Dimas | San Dimas | California | 91773 | — |
| Fomat Medical Research | Santa Maria | California | 93454 | — |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | — |
| Innovative Research of W FL | Clearwater | Florida | 33756 | — |
| Nature Coast Clin Rsrch_Crystal River | Crystal River | Florida | 34429 | — |
| Florida Premier Cardiology | Delray Beach | Florida | 33484 | — |
| Encore Medical Research LLC | Hollywood | Florida | 33024 | — |
| Est Cst Inst for Rsrch,Jksnvil | Jacksonville | Florida | 32216 | — |
| Jacksonville Ctr Clin Res | Jacksonville | Florida | 32216 | — |
| Clinical Research of Cent FL | Lakeland | Florida | 33805 | — |
| K2 Medical Research | Maitland | Florida | 32751 | — |
| Life Spring Research Foundation LLC | Miami | Florida | 33130 | — |
| Flourish Research - North Miami | Miami | Florida | 33138 | — |
| Oceane 7 Medical & Research Center, Inc. | Miami | Florida | 33144 | — |
| San Marcus Res Clin Miami Lakes | Miami Lakes | Florida | 33014 | — |
| Advance Rsch for Hlth Improvement_Naples | Naples | Florida | 34102 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Ocala Cardiovascular Research | Ocala | Florida | 34471 | — |
| Oviedo Medical Research, LLC | Oviedo | Florida | 32765 | — |
| Cardio Partners Clin Res Inst | Palm Beach Gardens | Florida | 33410 | — |
| Suncoast Clinical Research, Inc. | Palm Harbor | Florida | 34684 | — |
| Suncoast Research Associates LLC | Pembroke Pines | Florida | 33024 | — |
| Florida Kidney Physicians LLC | Riverview | Florida | 33578 | — |
| Care Access | Tamarac | Florida | 33321 | — |
| Cardiovascular Associates of America | Wellington | Florida | 33449-8095 | — |
| Javara/Privia Med Grp GA,LLC | Albany | Georgia | 31707 | — |
| West Georgia Cardiology | Carrollton | Georgia | 30117 | — |
| Cardiovascular Care Center & CRC | Conyers | Georgia | 30012 | — |
| Hope Clin Res & Wellness | Conyers | Georgia | 30094 | — |
| Core Clinical Trials | Cordele | Georgia | 31015 | — |
| NSC Research, Inc | Johns Creek | Georgia | 30024 | — |
| GA Arrhythmia Cons & Rsch Inst | Macon | Georgia | 31201 | — |
| Ukpong Cardiology Service | Moultrie | Georgia | 31768 | — |
| Javara Inc. / Privia Medical Group Georgia LLC | Peachtree City | Georgia | 30269 | — |
| Atlanta Heart Specialist | Tucker | Georgia | 30084 | — |
| Rocky Mountain Diab&Osteo Ctr | Idaho Falls | Idaho | 83404-7596 | — |
| Macoupin Research Group | Gillespie | Illinois | 62033 | — |
| Elevate Clinical Research | Gurnee | Illinois | 60031 | — |
| Chicago Medical Research LLC | Hazel Crest | Illinois | 60429 | — |
| Cardiovascular Associates of America | Moline | Illinois | 61265 | — |
| Genesis Orthopedics & Sports Medicine | Oak Brook | Illinois | 60523 | — |
| UnityPoint Health-Diabetes Care Center | Peoria | Illinois | 61603 | — |
| Cardiovascular Associates of America | Schaumburg | Illinois | 60173 | — |
| American Health Network of Indiana, LLC_Avon_0 | Avon | Indiana | 46123 | — |
| American Health Network of IN LLC_Franklin | Franklin | Indiana | 46131 | — |
| American Health Network of Indiana, LLC_Greenfield | Greenfield | Indiana | 46140 | — |
| American Health Network of IN LLC | Muncie | Indiana | 47304 | — |
| West Broadway Clinic | Council Bluffs | Iowa | 51501 | — |
| University of Iowa Prev Inter Ctr | Iowa City | Iowa | 52772 | — |
| Iowa Diab & Endo Res Center | West Des Moines | Iowa | 50266 | — |
| Cotton O'Neil Diab & Endo Ctr | Topeka | Kansas | 66606 | — |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | — |
| Norton Clinical Research Group | Louisville | Kentucky | 40217 | — |
| Grace Research, LLC | Bossier City | Louisiana | 71111 | — |
| Louisiana Heart Center | Covington | Louisiana | 70433 | — |
| Louisiana Heart Center_Slidell | Slidell | Louisiana | 70458 | — |
| MedStar Good Samaritan Hosp | Baltimore | Maryland | 21044 | — |
| Ascension Saint Agnes Heart Ca | Baltimore | Maryland | 21229 | — |
| Flourish Research Bowie | Bowie | Maryland | 20715 | — |
| Centennial Medical Group | Columbia | Maryland | 21045 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Elite Research Center | Flint | Michigan | 48532 | — |
| Arcturus Healthcare, PLC. | Troy | Michigan | 48098 | — |
| Trinity Health Michigan Heart | Ypsilanti | Michigan | 48197 | — |
| Clinical Research Professionals | Chesterfield | Missouri | 63005 | — |
| Clinical Research Consultants | Kansas City | Missouri | 64111 | — |
| The Alliance for Multispecialty Research LLC AMR | Kansas City | Missouri | 64114 | — |
| Headlands Research | Springfield | Missouri | 65807 | — |
| Amicis Centers of Clinical Research | St Louis | Missouri | 63128 | — |
| VA NEB - Western IA Health Stm | Omaha | Nebraska | 68105 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Palm Research Center Inc-Vegas | Las Vegas | Nevada | 89128 | — |
| Seacoast Kidney & Htn Specialists | Portsmouth | New Hampshire | 03801 | — |
| Central New York Clinical Research CNYCR | Manlius | New York | 13104 | — |
| Mid Hudson Med Res-New Windsor | New Windsor | New York | 12553 | — |
| NYU School of Medicine | New York | New York | 10016 | — |
| NYC Health + Hospitals/Lincoln | The Bronx | New York | 10451 | — |
| Great Lakes Medical Research | Westfield | New York | 14787 | — |
| Durham Nephrology Associates | Durham | North Carolina | 27704 | — |
| Medication Mgmnt, LLC_Grnsboro | Greensboro | North Carolina | 27405 | — |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | — |
| Piedmont Healthcare/Research | Statesville | North Carolina | 28625 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| Univ of Cincinnati Med Cent | Cincinnati | Ohio | 45267 | — |
| Advanced Med Res Maumee | Maumee | Ohio | 43537 | — |
| Tekton Research Inc | Moore | Oklahoma | 73160 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73072 | — |
| Heritage Valley Medical Group | Beaver | Pennsylvania | 15009 | — |
| Capital Area Research LLC | Newport | Pennsylvania | 17074 | — |
| Aria Endocrine Metabolic Assoc | Philadelphia | Pennsylvania | 19114 | — |
| Piedmont Research Partners, LLC | Fort Mill | South Carolina | 29707 | — |
| Carolina Nephrology Clinical Research | Greenville | South Carolina | 29605 | — |
| Accellacare US Inc._SC | Mt. Pleasant | South Carolina | 29464 | — |
| Carolina Health Specialists | Myrtle Beach | South Carolina | 29572 | — |
| Holston Medical Group Pc | Bristol | Tennessee | 37620-7352 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| MidState Endocrine Associates | Nashville | Tennessee | 37203 | — |
| PharmaTex Research | Amarillo | Texas | 79109 | — |
| Ascension Texas Cardiovascular | Austin | Texas | 78705 | — |
| Pinnacle Clinical Research | Austin | Texas | 78757 | — |
| Metropolitan Cardiology PA | Beaumont | Texas | 77701 | — |
| Javara Inc. / Privia Medical Group Gulf Coast PLLC | Conroe | Texas | 77384 | — |
| South Texas Clinical Research | Corpus Christi | Texas | 78404 | — |
| Thyroid Endocrinology & Diabetes PA | Dallas | Texas | 75208 | — |
| Baylor Jack and Jane Hamilton | Dallas | Texas | 75226 | — |
| Liberty Research Center_Dallas | Dallas | Texas | 75230 | — |
| Forefront Med Res Inst PLLC | Harlingen | Texas | 78550 | — |
| PrimeCare Medical Group | Houston | Texas | 77024 | — |
| JCCT- Juno NW Houston | Houston | Texas | 77040 | — |
| Northwest Houston Cardiology, P.A. | Houston | Texas | 77070 | — |
| Endocrine And Psychiatry Center | Houston | Texas | 77095 | — |
| DCOL Ctr for Clin Res | Longview | Texas | 75605 | — |
| Texas Inst, Kdny & Endo Disor | Lufkin | Texas | 75904 | — |
| PRX Research | Mesquite | Texas | 75149 | — |
| Ascension Texas Cardiovascular | Round Rock | Texas | 78665 | — |
| Clinical Advancement Center | San Antonio | Texas | 78212 | — |
| Sun Research Institute | San Antonio | Texas | 78215 | — |
| The IMA Group IMA Clinical Trials of America Inc. CTA | San Antonio | Texas | 78229 | — |
| Univ Of Texas Hlth Science Cntr | San Antonio | Texas | 78229 | — |
| VIP Trials | San Antonio | Texas | 78230 | — |
| Simcare Medical Research, LLC | Sugar Land | Texas | 77478 | — |
| Houston Research Institute | Sugar Land | Texas | 77479 | — |
| Northwest Houston Clinical Research, PLLC | Tomball | Texas | 77375 | — |
| Crossroads Clinical Res- Texas | Victoria | Texas | 77901 | — |
| Progressive Clinical Research UT | Bountiful | Utah | 84010 | — |
| AMR Clinical | Layton | Utah | 84041 | — |
| Kalo Clinical Research | West Valley City | Utah | 84120 | — |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | — |
| TPMG Clinical Research | Newport News | Virginia | 23606 | — |
| Sentara Health Research Center | Norfolk | Virginia | 23507 | — |
| Dominion Medical Associates | Richmond | Virginia | 23219 | — |
| VA Medical Center_Salem | Salem | Virginia | 24153-6404 | — |
| Conquest Research | Vienna | Virginia | 22182 | — |
| Selma Medical Associates | Winchester | Virginia | 22601-3834 | — |
| Providence Medical Research Center | Spokane | Washington | 99204 | — |
| St. Vincent Hosp-Prevea Health | Green Bay | Wisconsin | 54303 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 614 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07861100, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 6, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07861100 live on ClinicalTrials.gov.