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Recruiting Phase 3 Interventional

Phase 3 Study of Intravitreal 4D-150 in Adults With Diabetic Macular Edema (DME) (4D-150-C005)

ClinicalTrials.gov ID: NCT07867080

Public ClinicalTrials.gov record NCT07867080. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 9, 2026, 12:54 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-Masked, Active-Controlled Trial to Evaluate the Efficacy, Safety, and Durability of a Single Intravitreal Injection of 4D-150 Versus Aflibercept in Adults With Diabetic Macular Edema (4SIGHT)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

A Phase 3, Randomized, Double-Masked, Active-Controlled Trial to Evaluate the Safety, Efficacy, and Durability of a Single Intravitreal Injection of 4D-150 versus Aflibercept in Adults with Diabetic Macular Edema (4SIGHT)

Study identification

NCT ID
NCT07867080
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
4D Molecular Therapeutics
Industry
Enrollment
514 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Sep 18, 2026 (Actual)
Primary completion
Jan 2029 (Estimated)
Completion
Jan 2030 (Estimated)
Last update posted
Oct 9, 2026

2026 – 2030

United States locations

U.S. sites
49
U.S. states
21
U.S. cities
47
Facility City State ZIP Site status
Research Network Arizona Scottsdale Arizona 85255 Recruiting
The Retina Partners Encino California 91436 Recruiting
Retina Consultants of Orange County Fullerton California 92835 Not yet recruiting
Retinal Consultants Medical Group Inc. Sacramento California 95825 Not yet recruiting
Retina Consultants San Diego San Diego California 92064 Not yet recruiting
Retina Institute of New England San Mateo California 94401 Not yet recruiting
Bay Area Retina Associates - Walnut Creek Walnut Creek California 94598 Not yet recruiting
Retina Specialists of Colorado - Aurora Aurora Colorado 80012 Recruiting
Retina Consultants of Southern Colorado P.C. Colorado Springs Colorado 80909 Not yet recruiting
Southwest Retina Consultants Durango Colorado 81303 Not yet recruiting
Coastal Eye- Greenwich Greenwich Connecticut 06830 Not yet recruiting
Retina Institute of New England, PC Waterford Connecticut 06385 Not yet recruiting
Florida Retina Institute Orlando Florida 32806 Not yet recruiting
Retinal Specialty Institute Pensacola Florida 32503 Recruiting
Fort Lauderdale Eye Institute (FLEI)-Plantation Plantation Florida 33324 Not yet recruiting
Retina Vitreous Associates of Florida Tampa Florida 33607 Recruiting
Retina Associates, Ltd. Elmhurst Illinois 60126 Recruiting
University Retina and Macula Associates Oak Forest Illinois 60452 Not yet recruiting
Illinois Retina Associates Oak Park Illinois 60304 Not yet recruiting
Springfield Clinic Springfield Illinois 62703 Not yet recruiting
Midwest Eye Institute Carmel Indiana 46032 Not yet recruiting
The Retina Group of Washington Chevy Chase Maryland 20815 Not yet recruiting
Cumberland Valley Retina Consultants Hagerstown Maryland 21740 Not yet recruiting
Mid Atlantic Retina Specialist Hagerstown Maryland 21740 Not yet recruiting
Mississippi Retina Associates Madison Mississippi 39110 Not yet recruiting
Deep Blue Retina Clinical Research, PLLC Southaven Mississippi 38671 Not yet recruiting
The Retina Institute St Louis Missouri 63128 Not yet recruiting
Sierra Eye Associates Reno Nevada 89502 Recruiting
Envision Ocular, LLC Bloomfield New Jersey 07003 Not yet recruiting
NJ Retina Edison New Jersey 08820 Not yet recruiting
NYU Langone Health New York New York 10017 Not yet recruiting
Retina Vitreous Surgeons of CNY, PC New York New York 13088 Not yet recruiting
Vitreoretinal Consultants of New York (VRCNY) Westbury New York 11590 Not yet recruiting
Asheville Eye Associates - Retina Division Asheville North Carolina 28803 Not yet recruiting
North Carolina Retina Associates- Wake Forest Wake Forest North Carolina 27587 Not yet recruiting
Retina Vitreous Center Edmund Oklahoma 73013 Not yet recruiting
EyeHealth Northwest Portland Oregon 97233 Not yet recruiting
Mid Atlantic Retina Bethlehem Pennsylvania 18017 Not yet recruiting
Black Hills Regional Eye Institute Rapid City South Dakota 57701 Not yet recruiting
West Texas Retina Consultants Abilene Texas 79606 Not yet recruiting
Austin Clinical Research Austin Texas 78750 Recruiting
Texas Retina Associate Dallas Texas 75231 Not yet recruiting
Texas Retina Center Houston Texas 77030 Recruiting
Retina Consultants of Texas - Katy Katy Texas 77494 Not yet recruiting
Retina Consultants of Texas The Woodlands Texas 77384 Not yet recruiting
Tyler Retina Consultants Tyler Texas 75703 Not yet recruiting
The Retina Group of Washington Fairfax Virginia 22031 Not yet recruiting
Piedmont Eye Center Lynchburg Virginia 24502 Not yet recruiting
Eye Clinic of Wisconsin Wausau Wisconsin 55403 Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 33 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07867080, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 9, 2026 · Synced Oct 9, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07867080 live on ClinicalTrials.gov.

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