Flavored Electronic Nicotine Delivery Systems to Lower Smoking and Exposure to Tobacco Toxicants Among Cigarette Smokers Interested in Quitting, REFLECT Trial
Public ClinicalTrials.gov record NCT07896330. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Two-Arm Randomized Clinical Trial of Individuals Who Smoke Tobacco Cigarettes and Initiate ENDS Use With Fruit or Tobacco Flavors (Reducing Smoking With Flavored E-Cigarettes Trial; REFLECT)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This clinical trial studies whether different flavored electronic nicotine delivery systems (ENDS) help lower smoking and exposure to tobacco toxicants among cigarette smokers interested in reducing their smoking. ENDS are battery-powered electronic devices designed to deliver a nicotine-containing liquid solution for inhalation. They do not burn tobacco. Previous research has shown that ENDS have the potential to lower exposure to potentially toxic substances compared to burned cigarettes as well as lower short-term adverse health outcomes. However, there are many different ENDS products with varying characteristics, including different flavors, and a need remains to understand more how flavors affect ENDS use, the potential reduction in cigarette use, and exposure to toxicants. This trial studies how two different flavors, fruit and tobacco, affect an individual's smoking behavior and ultimately whether flavored ENDS can help lower smoking and exposure to tobacco toxicants among cigarette smokers interested in reducing their smoking.
Study identification
- NCT ID
- NCT07896330
- Recruitment status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 286 participants
Conditions and interventions
Interventions
- Vaping - Fruit flavored ENDS Other
- Biospecimen Collection Procedure
- Vaping - tobacco flavored ENDS Other
Other · Procedure
Eligibility (public fields only)
- Age range
- 21 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 30, 2026 (Estimated)
- Primary completion
- Nov 30, 2027 (Estimated)
- Completion
- Nov 30, 2027 (Estimated)
- Last update posted
- Oct 27, 2026
2026 – 2027
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Roswell Park Comprehensive Cancer Center | Buffalo | New York | 14263 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07896330, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 27, 2026 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07896330 live on ClinicalTrials.gov.