A Study to Learn How Well People With Bronchiectasis Tolerate Continued Treatment With Verducatib After Earlier Studies (AIRTIVITY®-ON)
Public ClinicalTrials.gov record NCT07915219. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
An Open-label, Roll-over Study Evaluating the Long-term Safety and Efficacy of an Oral Dose of Verducatib q.d. in Patients With Bronchiectasis (AIRTIVITY®-ON)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is for adults and adolescents who are at least 12 years old and have bronchiectasis. People can participate if they completed a previous study with the study medicine called verducatib. The purpose of this study is to find out how well verducatib is tolerated when people with bronchiectasis take it for a long time. The study also looks at breathing problems, how often lung flare-ups happen, and how quickly lung function changes. This is a roll-over study for participants who completed a previous study with verducatib: AIRTIVITY® (1397-0014) or CLAIRLEAF® (1397-0017). All participants receive verducatib. Participants take verducatib as tablets once a day at home. They may continue their usual treatment for bronchiectasis during the study. Participants can stay in the study for up to 1 year and 9 months. Treatment with verducatib can continue for up to 1 year and 6 months. About 6 study visits are done at the study site and about 4 are done by phone. At all visits, the doctors check participants' health and collect information on any health problems that occur during the study. The doctors also look at lung flare-ups and measure lung function over time.
Study identification
- NCT ID
- NCT07915219
- Recruitment status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,500 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 11, 2027 (Estimated)
- Primary completion
- Jul 31, 2029 (Estimated)
- Completion
- Sep 10, 2029 (Estimated)
- Last update posted
- Nov 4, 2026
2027 – 2029
United States locations
- U.S. sites
- 48
- U.S. states
- 21
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arizona | Tucson | Arizona | 85724 | — |
| Newport Native MD, Inc | Newport Beach | California | 92663 | — |
| Paradigm Clinical Research - Redding | Redding | California | 96001 | — |
| University of California Davis | Sacramento | California | 95817 | — |
| National Jewish Health | Denver | Colorado | 80206 | — |
| Meris Clinical Research-Brandon-69466 | Brandon | Florida | 33511 | — |
| University of Florida College of Medicine | Jacksonville | Florida | 32209 | — |
| Mayo Clinic - Florida | Jacksonville | Florida | 32224 | — |
| Essence MD Research | Naples | Florida | 34102 | — |
| Vantage Clinical Trials - Tampa | Tampa | Florida | 33614 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Mayo Clinic, Rochester | Rochester | Minnesota | 55905 | — |
| HealthPartners Specialty Center 401 Building | Saint Paul | Minnesota | 55130 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-5910 | — |
| New York Medical College - Hawthorne | Hawthorne | New York | 10532 | — |
| Northwell Health | New Hyde Park | New York | 11040 | — |
| New York University Langone Medical Center | New York | New York | 10017 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| New York Presbyterian Hospital -Columbia University | New York | New York | 10032 | — |
| Stern Research Partners, LLC | Huntersville | North Carolina | 28078 | — |
| Pinehurst Medical Clinic, Inc. - East | Pinehurst | North Carolina | 28374 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Clinical Research Associates of Central PA | DuBois | Pennsylvania | 15801 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Jefferson Health Honickman Center | Philadelphia | Pennsylvania | 19107 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Clinical Research of Rock Hill | Rock Hill | South Carolina | 29732 | — |
| Horizon Clinical Research Group | Cypress | Texas | 77429 | — |
| Baylor University Medical Center | Dallas | Texas | 75246 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| El Paso Pulmonary Association | El Paso | Texas | 79902 | — |
| University of Texas Medical Branch at Galveston | Galveston | Texas | 77555 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Metroplex Pulmonary & Sleep Center | McKinney | Texas | 75069 | — |
| IMA Clinical Research San Antonio | San Antonio | Texas | 78229 | — |
| University of Texas Health Science Center at Tyler | Tyler | Texas | 75708 | — |
| Intermountain Healthcare | Murray | Utah | 84107-4107 | — |
| University of Vermont | Colchester | Vermont | 05446 | — |
| Inova Fairfax Medical Campus | Falls Church | Virginia | 22042 | — |
| Virginia Commonwealth University Health Systems | Richmond | Virginia | 23219 | — |
| University of Washington | Seattle | Washington | 98195 | — |
| Providence Medical Research Center | Spokane | Washington | 99204 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 335 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07915219, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 4, 2026 · Synced Nov 6, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07915219 live on ClinicalTrials.gov.