A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)
Public ClinicalTrials.gov record NCT07919678. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO ASSESS THE EFFICACY AND SAFETY OF ONCE-MONTHLY BEROBENATIDE IN ADULTS WITH KNEE OSTEOARTHRITIS AND OVERWEIGHT OR OBESITY (VESPER-OA 1)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this clinical study is to learn about the safety and effects of berobenatide (PF-08653944) for the treatment of knee osteoarthritis in adults with overweight or obesity. The study will last 52 weeks and compare the effects of berobenatide compared to placebo on knee pain, physical function, and body weight. Study activities will include blood tests, knee pain assessment, physical function questionnaires and body measurements.
Study identification
- NCT ID
- NCT07919678
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 656 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 26, 2026 (Actual)
- Primary completion
- Aug 22, 2028 (Estimated)
- Completion
- Oct 10, 2028 (Estimated)
- Last update posted
- Nov 5, 2026
2026 – 2028
United States locations
- U.S. sites
- 39
- U.S. states
- 15
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AMR Clinical | Tempe | Arizona | 85281 | Not yet recruiting |
| Headlands Research California, LLC | Escondido | California | 92025 | Not yet recruiting |
| Prospective Research Innovations Inc. | Rancho Cucamonga | California | 91730 | Not yet recruiting |
| Solace Clinical Research | Tustin | California | 92780 | Not yet recruiting |
| Skylight Health Research | Colorado Springs | Colorado | 80917 | Not yet recruiting |
| Clinical Research of West Florida, Inc. | Clearwater | Florida | 33765 | Not yet recruiting |
| Universal Axon Clinical Research LLC | Doral | Florida | 33166 | Recruiting |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | Not yet recruiting |
| Renstar Medical Research | Lady Lake | Florida | 32159 | Not yet recruiting |
| Renstar Medical Research | Ocala | Florida | 34470 | Not yet recruiting |
| Clinical Research of West Florida, Inc. | Tampa | Florida | 33606 | Not yet recruiting |
| Clinical Research Atlanta | Stockbridge | Georgia | 30281 | Not yet recruiting |
| North Georgia Clinical Research, LLC | Woodstock | Georgia | 30189 | Not yet recruiting |
| North Georgia Internal Medicine | Woodstock | Georgia | 30189 | Not yet recruiting |
| Northwestern Medicine | Chicago | Illinois | 60611 | Not yet recruiting |
| Northwestern Memorial Hospital, Diagnostic Testing Center (Phlebotomy/EKG) | Chicago | Illinois | 60611 | Not yet recruiting |
| Northwestern Memorial Hospital, Investigational Drug Service | Chicago | Illinois | 60611 | Not yet recruiting |
| Northwestern University Feinberg School Of Medicine | Chicago | Illinois | 60611 | Not yet recruiting |
| Great Lakes Clinical Trials, LLC dba Flourish Research | Chicago | Illinois | 60640 | Not yet recruiting |
| Elevate Clinical Research | Wichita | Kansas | 67214 | Not yet recruiting |
| BRCR Global Louisiana | Gretna | Louisiana | 70053 | Not yet recruiting |
| Profound Research LLC | Farmington Hills | Michigan | 48334 | Recruiting |
| Revive Research Institute, Inc. | Sterling Heights | Michigan | 48313 | Recruiting |
| Albuquerque Clinical Trials, Inc. | Albuquerque | New Mexico | 87102 | Not yet recruiting |
| Novant Health Granite Quarry Internal Medicine (knee x-ray) | Granite Quarry | North Carolina | 28146 | Not yet recruiting |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | Recruiting |
| Accellacare - Salisbury | Salisbury | North Carolina | 28144 | Not yet recruiting |
| Accellacare | Wilmington | North Carolina | 28401 | Recruiting |
| Delaney Radiologist | Wilmington | North Carolina | 28401 | Recruiting |
| AMR Clinical | Norman | Oklahoma | 73069 | Not yet recruiting |
| Altoona Center For Clinical Research | Duncansville | Pennsylvania | 16635 | Recruiting |
| Mercy Family Clinic | Dallas | Texas | 75208 | Not yet recruiting |
| Cedar Health Research | Fort Worth | Texas | 76132 | Not yet recruiting |
| JCCT-JUNO NW Houston | Houston | Texas | 77040 | Not yet recruiting |
| Activian Clinical Research | Kingwood | Texas | 77339 | Not yet recruiting |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | Not yet recruiting |
| DM Clinical Research | Tomball | Texas | 77375 | Not yet recruiting |
| Velocity Clinical Research, Waco | Waco | Texas | 76710 | Not yet recruiting |
| Charlottesville Medical Research Center, LLC | Charlottesville | Virginia | 22911 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07919678, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 5, 2026 · Synced Nov 6, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07919678 live on ClinicalTrials.gov.