Low-Intensity Focused Ultrasound for Gambling Disorder

ClinicalTrials.gov ID: NCT07923032

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Official title

A Randomized, Sham-Controlled Trial of Low Intensity Focused Ultrasound Neuromodulation as an Adjunctive Treatment for Gambling Disorder

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The goal of this clinical trial is to learn whether low-intensity focused ultrasound (LIFU) is safe and may help reduce gambling-related symptoms in adults seeking treatment for gambling disorder. The main questions it aims to answer are: * Is LIFU safe and well tolerated in adults with gambling disorder? * Does LIFU reduce gambling behavior compared with a sham (inactive) procedure? Researchers will compare participants who receive active LIFU with participants who receive sham LIFU to see whether active treatment leads to greater reductions in gambling behavior. Participants will: * Be randomly assigned to receive either active LIFU or sham LIFU. * Receive nine treatment sessions delivered over three treatment days within a five-day period. * Participate in weekly telehealth cognitive behavioral therapy (CBT). * Complete assessments of gambling behavior, gambling urges, mood, and quality of life. * Attend follow-up visits for up to 90 days after active LIFU treatment. Low-intensity focused ultrasound is a noninvasive technique that uses focused sound waves to influence brain activity. Researchers believe this approach may affect brain circuits involved in reward, cravings, and decision-making that contribute to gambling disorder.

Study identification

NCT ID: NCT07923032
Recruitment status: Not yet recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: University of Virginia; Other
Enrollment: 54 participants

Conditions and interventions

Conditions

Interventions

Device

Eligibility (public fields only)

Age range: 18 Years to 60 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 2027 (Estimated)
Primary completion: Dec 2028 (Estimated)
Completion: Jun 2029 (Estimated)
Last update posted: Nov 6, 2026

2027 – 2029

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
University of Virginia	Charlottesville	Virginia	22903	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07923032, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Nov 6, 2026 · Synced Nov 12, 2026