A Study of Brenipatide in Participants With Major Depressive Disorder
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This page only displays public information reproduced from the official ClinicalTrials.gov record NCT07928245. It adds no medical advice, opinions, or eligibility judgments. The official record remains the source of truth for eligibility criteria, enrollment, and contact information.
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Official title
A Phase 2, Multicenter, Randomized, Double-blind, Parallel-arm Study to Investigate the Efficacy and Safety of Adjunctive Treatment With Brenipatide Compared With Placebo in Adult Participants With Major Depressive Disorder Who Have Partial Response to Antidepressant Therapy (RENEW-MDD-3)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study evaluates the safety and efficacy of brenipatide (LY3537031) as an add on therapy in participants with major depression who still have symptoms while taking a stable dose of standard of care anti-depressant medicine. The study will last approximately 5 months.
Study identification
- NCT ID
- NCT07928245
- Recruitment status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 330 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2026 (Estimated)
- Primary completion
- May 2028 (Estimated)
- Completion
- Jul 2028 (Estimated)
- Last update posted
- Nov 10, 2026
2026 – 2028
United States locations
- U.S. sites
- 35
- U.S. states
- 12
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| IMA Clinical Research - Phoenix | Phoenix | Arizona | 85012 | — |
| Inland Psychiatric Medical Group | Chino | California | 91710 | — |
| Catalina Research Institute, LLC | Montclair | California | 91763 | — |
| Excell Research | Oceanside | California | 92056 | — |
| California Neuroscience Research Medical Group, Inc. | Sherman Oaks | California | 91403 | — |
| Alliance Clinical West Hills | West Hills | California | 91307 | — |
| The Medici Medical Research | Hollywood | Florida | 33021-6758 | — |
| Research Centers of America, LLC-Hollywood | Hollywood | Florida | 33024 | — |
| Clinical Neuroscience Solutions, Inc. dba CNS Healthcare | Jacksonville | Florida | 32256 | — |
| Combined Research Orlando Phase I-IV LLC | Orlando | Florida | 32807 | — |
| Denali Health - Plant City, FL | Plant City | Florida | 33563 | — |
| ForCare Clinical Research | Tampa | Florida | 33613 | — |
| Neuroscience Research Institute - West Palm Beach | West Palm Beach | Florida | 33407 | — |
| Synexus Clinical Research | Atlanta | Georgia | 30328 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30331 | — |
| CenExel iResearch, LLC | Decatur | Georgia | 30030 | — |
| CenExel iResearch, LLC | Savannah | Georgia | 31405 | — |
| Adams Clinical Boston | Boston | Massachusetts | 02116 | — |
| Boston Clinical Trials | Boston | Massachusetts | 02131 | — |
| Adams Clinical | Watertown | Massachusetts | 02472 | — |
| IMA Clinical Research Las Vegas | Las Vegas | Nevada | 89102 | — |
| Hassman Research Institute Marlton Site | Marlton | New Jersey | 08053 | — |
| Bio Behavioral Health | Toms River | New Jersey | 08755 | — |
| Neurobehavioral Research Inc | Cedarhurst | New York | 11516 | — |
| Bioscience Research, LLC | Mount Kisco | New York | 10128 | — |
| Adams Clinical Harlem | New York | New York | 10029 | — |
| IMA Clinical Research NYC Midtown | New York | New York | 10036 | — |
| Richmond Behavioral Associates | Staten Island | New York | 10314 | — |
| Lehigh Center for Clinical Research | Allentown | Pennsylvania | 18103 | — |
| Adams Clinical Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| IMA Clinical Research Austin - Northland | Austin | Texas | 78731 | — |
| Lonestar Clinical Research | Dallas | Texas | 75243 | — |
| Adams Clinical Dallas | DeSoto | Texas | 75115 | — |
| Inspire Behavioral Health | Fairfax | Virginia | 22030 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 40 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07928245, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 10, 2026 · Synced Nov 14, 2026
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