A Research Study Investigating How Well Zenagamtide at Lower Dose Levels Lowers Blood Sugar and Body Weight Compared to Semaglutide at Lower Dose Levels in People With Type 2 Diabetes Treated With Metformin, Sodium-Glucose Cotransporter 2 Inhibitors (SGLT2i), or Both
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This page only displays public information reproduced from the official ClinicalTrials.gov record NCT07931599. It adds no medical advice, opinions, or eligibility judgments. The official record remains the source of truth for eligibility criteria, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of Zenagamtide s.c. Once Weekly Compared to Semaglutide s.c. Once Weekly at Lower Dose Levels in Participants With Type 2 Diabetes Inadequately Controlled on Metformin, SGLT2i, or Both
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study is testing zenagamtide in participants with type 2 diabetes. The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have type 2 diabetes. Participants will either get zenagamtide or semaglutide. Which treatment participants get is decided by chance. Zenagamtide is a new medicine that doctors cannot prescribe yet, but it has been tested in humans before.
Study identification
- NCT ID
- NCT07931599
- Recruitment status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,060 participants
Conditions and interventions
Conditions
Interventions
- Zenagamtide Drug
- Semaglutide Drug
- Placebo zenagamtide Drug
- Placebo semaglutide Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 10, 2026 (Estimated)
- Primary completion
- Jul 24, 2028 (Estimated)
- Completion
- Aug 28, 2028 (Estimated)
- Last update posted
- Nov 12, 2026
2026 – 2028
United States locations
- U.S. sites
- 41
- U.S. states
- 21
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Scripps Whittier Diabetes Inst | La Jolla | California | 92037 | — |
| First Valley Medical Group | Lancaster | California | 93534 | — |
| Headlands Research CTR Lincoln | Lincoln | California | 95648 | — |
| Desert Oasis Hlthcr Med Group | Palm Springs | California | 92262 | — |
| UC Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Northeast Research Institute | Fleming Island | Florida | 32003 | — |
| Encore Medical Research LLC | Hollywood | Florida | 33024 | — |
| Northeast Research Institute | Jacksonville | Florida | 32204 | — |
| University of Florida, College of Medicine Jacksonville | Jacksonville | Florida | 32256 | — |
| My Preferred Research | Miami | Florida | 33155 | — |
| New Horizon Research Center | Miami | Florida | 33165 | — |
| Adult Medicine of Lake County, Inc | Mt. Dora | Florida | 32757 | — |
| True Blue Clinical Research | Tampa | Florida | 36607 | — |
| Encore Medical Research of Weston | Weston | Florida | 33331 | — |
| Hope Clin Res & Wellness | Conyers | Georgia | 30094 | — |
| Cedar-Crosse Research Center | Chicago | Illinois | 60607 | — |
| Iowa Diab & Endo Res Center | West Des Moines | Iowa | 50266 | — |
| Alliance for Multispec Res | Newton | Kansas | 67114 | — |
| MedStar Health Research Institute | Olney | Maryland | 20832 | — |
| Endo And Metab Cons | Rockville | Maryland | 20852 | — |
| Elite Clinical Research Center | Flint | Michigan | 48532 | — |
| Diabetes & Endo Specialists Inc | Chesterfield | Missouri | 63017 | — |
| StudyMetrix Research LLC | City of Saint Peters | Missouri | 63303 | — |
| Palm Research Center Inc-Vegas | Las Vegas | Nevada | 89148 | — |
| Southern NH Diabetes and Endo_Nashua | Nashua | New Hampshire | 03060 | — |
| AMC Community Endocrinology | Albany | New York | 12203 | — |
| Southgate Medical Group, LLP | West Seneca | New York | 14224 | — |
| Great Lakes Medical Research | Westfield | New York | 14787 | — |
| PHC Accelacare | Statesville | North Carolina | 28625 | — |
| Diab & Endo Assoc of Stark Co | Canton | Ohio | 44718 | — |
| Tribe Clinical Research LLC | Greer | South Carolina | 29650 | — |
| South Dakota Urban Indian Health | Sioux Falls | South Dakota | 57104 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| Clinical Research Associates | Nashville | Tennessee | 37203 | — |
| Victorium Clinical Research | Houston | Texas | 77024 | — |
| Southwest Clinical Trials | Houston | Texas | 77081 | — |
| Medical Colleagues-Texas LLP | Katy | Texas | 77450 | — |
| Pinnacle Clinical Research | San Antonio | Texas | 78222 | — |
| Northeast Clinical Research of San Antonio | San Antonio | Texas | 78233 | — |
| Diabetes & Endo Treatment Spec | Sandy City | Utah | 84093 | — |
| Tidewater Physicians Multispecialty Group | Newport News | Virginia | 23606 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 111 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07931599, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 12, 2026 · Synced Nov 14, 2026
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