Lifestyle Strategies to Preserve Muscle and Reduce Cardiovascular Risk in Adults With Obesity Using GLP-1 Receptor Agonists

ClinicalTrials.gov ID: NCT07933393

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study will test whether adding a lifestyle program to GLP-1 medication treatment can help preserve muscle, reduce cardiovascular risk, and improve quality of life in adults with overweight or obesity. About 670 adults who are starting a GLP-1 medication for weight loss will be enrolled. Participants will be randomly assigned to either a 6-month YMCA lifestyle program that includes resistance exercise and nutrition support, or to enhanced usual care with monthly health education workshops. Study assessments will occur at baseline, 6 months, and 12 months. The main outcome is the change in appendicular lean tissue mass measured by DXA at 6 months. Other outcomes include cardiovascular risk, quality of life, bone density, total lean mass, weight loss, dietary intake, and physical activity.

Study identification

NCT ID: NCT07933393
Recruitment status: Not yet recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: University of Florida; Other
Enrollment: 670 participants

Conditions and interventions

Conditions

Obesity & Overweight

Interventions

GLP-1 Lifestyle Management Program Behavioral
Enhanced Usual Care Health Education Behavioral

Behavioral

Eligibility (public fields only)

Age range: 30 Years to 79 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 15, 2027 (Estimated)
Primary completion: Nov 15, 2031 (Estimated)
Completion: Mar 15, 2032 (Estimated)
Last update posted: Nov 12, 2026

2027 – 2032

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
First Coast YMCA sites	Jacksonville	Florida	32202	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07933393, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Nov 12, 2026 · Synced Nov 13, 2026