Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 30, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 30, 2026, 6:54 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 1225–1236 of 5,335 matching trials for Depression.

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Live official records

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Conditions: Major Depressive Disorder, Treatment Resistant Depression
Interventions: Low-Intensity Focused Ultrasound Pulsation, Sham Low-Intensity Focused Ultrasound Pulsation; Device
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 70 Years
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Obstructive Sleep Apnea
Interventions: BLT, s-BLT; Other
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 40 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Depression
Interventions: Parent Skills Training, Protecting Families Program (PFP); Behavioral
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 9 Years and older
Enrollment: 42 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2005 – 2009
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Treatment Resistant Depression (TRD)
Interventions: aiTBS; Device
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 18 Years to 65 Years
Enrollment: 247 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 3
States / cities: San Diego, California • New York, New York • Dallas, Texas

Conditions: Major Depressive Disorder, Alcohol Use Disorder
Interventions: allogeneic human mesenchymal stem cells (allo-hMSCs), Placebo; Drug
Lead sponsor: Ihsan M Salloum, MD, MPH; Other
Eligibility: 18 Years to 75 Years
Enrollment: 31 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2025
U.S. locations: 1
States / cities: Harlingen, Texas

Conditions: Nasal Congestion and Inflammations, Sinus Congestion Chronic
Interventions: SinuSonic; Other
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 99 Years
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Opioid-Related Disorders
Interventions: Treating Opioid Patients' Pain and Sadness (TOPPS), Health Education (HE); Behavioral
Lead sponsor: Boston University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 163 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2024
U.S. locations: 2
States / cities: Boston, Massachusetts • Fall River, Massachusetts

Conditions: Depression, Cancer, Adolescent, Young Adult, Adult
Interventions: AYA Survivors Coping and Emotional Needs Toolkit (ASCENT); Behavioral
Lead sponsor: East Carolina University; Other
Eligibility: 15 Years to 39 Years
Enrollment: 208 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 2
States / cities: Greenville, North Carolina • Winston-Salem, North Carolina

Conditions: Depression, Alcoholism, Drug Abuse
Interventions: Interpersonal and Social Rhythm Therapy (ISRT), Bipolar-Specific Cognitive Behavioral Therapy (CBT), Mindfulness-Based Stress Reduction (MBSR), Psycho-education & Understanding Bipolar Medications Therapy; Behavioral
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 64 Years
Enrollment: 130 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2026
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: COVID-19 Pandemic, Health Knowledge, Attitudes, Practice, Perinatal Depression, Mental Health Wellness, Post Partum Depression
Interventions: Baby2Home Mobile Application; Other
Lead sponsor: Women and Infants Hospital of Rhode Island; Other
Eligibility: 18 Years and older
Enrollment: 642 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 2
States / cities: Chicago, Illinois • Providence, Rhode Island

Conditions: Depression - Major Depressive Disorder
Interventions: Not listed
Lead sponsor: Boston Sight; Other
Eligibility: Not listed
Enrollment: 200 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2029
U.S. locations: 1
States / cities: Needham, Massachusetts

Conditions: Anxiety, Depression
Interventions: Pramipexole Oral Tablet; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 167 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2025
U.S. locations: 3
States / cities: Los Altos, California • Palo Alto, California • Stanford, California

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

Filter and sort this condition

Live official records

Low-Intensity Focused Ultrasound for Treatment-Resistant Depression

Bright Light Therapy for OSA

Effect of Family-Based Prevention on Children of Depressed Parents

Neuronavigated aiTBS for TRD

Allogeneic Human Mesenchymal Stem Cell Infusion vs Placebo in Alcohol Use Disorder and Major Depression.

Effects of SinuSonic on Psychological and Physical Well-Being

Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings

Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit

Suicidal Behavior in Patients Diagnosed With Bipolar Disorder

Baby2Home (B2H) Mobile Health Application

The Effect of PROSE or Scleral Lenses on Mental Health

Stanford RAD-AT Study (Research on Anxiety and Depression - Anhedonia Treatment)

About this Depression clinical trials directory page