- Conditions
- Artificial Intelligence (AI)
- Interventions
- Biometrics (or AI Biomaker)
- Device
- Lead sponsor
- University Hospitals Cleveland Medical Center
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2027 – 2028
- U.S. locations
- 1
- States / cities
- Cleveland, Ohio
Condition Directory
Depression clinical trials
Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.
By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 26, 2026 Report an issue
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official matching trials
5328
Shown on this page
12
Current sort
Recently updated
Condition scope
Depression
Additional filters apply within this condition.
These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.
How Depression studies are organized in the registry
Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.
Terms that often appear in related listings
These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.
Showing 277–288 of 5,328 matching trials for Depression.
Live ClinicalTrials.gov results.
Live official records
Open in full search- Conditions
- Adjustment Disorder
- Interventions
- RE104 for Injection
- Drug
- Lead sponsor
- Reunion Neuroscience Inc
- Industry
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 100 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2026
- U.S. locations
- 32
- States / cities
- Birmingham, Alabama • Tucson, Arizona • San Diego, California + 28 more
- Conditions
- Depression, Depression, Bipolar
- Interventions
- Observational Study
- Other
- Lead sponsor
- University of Texas Southwestern Medical Center
- Other
- Eligibility
- 10 Years and older
- Enrollment
- 2,500 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2016 – 2036
- U.S. locations
- 1
- States / cities
- Dallas, Texas
- Conditions
- Premature Birth, Pregnancy Preterm, Prenatal Stress, Depression, Anxiety, Depression, Postpartum, Satisfaction, Patient, Health Problems in Pregnancy
- Interventions
- Glow! Group Prenatal Care, Individual Prenatal Care with CPSP
- Other
- Lead sponsor
- University of California, San Francisco
- Other
- Eligibility
- Female only
- Enrollment
- 678 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2019 – 2024
- U.S. locations
- 2
- States / cities
- Fresno, California • San Francisco, California
- Conditions
- Pain, Depression
- Interventions
- Computer game/task, Health surveys online
- Behavioral
- Lead sponsor
- University of Minnesota
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 48 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2022 – 2027
- U.S. locations
- 1
- States / cities
- Minneapolis, Minnesota
- Conditions
- Healthy, Major Depressive Disorder, Treatment Resistant Depression
- Interventions
- Ketamine, Saline
- Drug · Other
- Lead sponsor
- Texas A&M University
- Other
- Eligibility
- 21 Years to 45 Years
- Enrollment
- 100 participants
- Healthy volunteers
- Accepts healthy volunteers
- Timeline
- 2024 – 2026
- U.S. locations
- 2
- States / cities
- Houston, Texas
- Conditions
- Breast Cancer, Breast Cancer Female, Breast Cancer Stage I, Breast Cancer Stage II, Breast Cancer Stage III, Mild Depression, Moderate Depression
- Interventions
- MBCT
- Other
- Lead sponsor
- Case Comprehensive Cancer Center
- Other
- Eligibility
- 65 Years and older · Female only
- Enrollment
- 23 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2025 – 2026
- U.S. locations
- 1
- States / cities
- Cleveland, Ohio
- Conditions
- Excessive Gestational Weight Gain, Pregnancy, INTUITIVE EATING, Perceived Stress, Prenatal Depression, Anxiety, Diet Quality, Physical Activity, Body Awareness
- Interventions
- Intuitive Eating Intervention
- Other
- Lead sponsor
- San Diego State University
- Other
- Eligibility
- 18 Years and older · Female only
- Enrollment
- 80 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2027
- U.S. locations
- 2
- States / cities
- San Diego, California
- Conditions
- Epilepsy, Depression, Anxiety, Emotions
- Interventions
- Viewing visual stimuli and electrical stimulation of the brain
- Behavioral
- Lead sponsor
- University of California, San Francisco
- Other
- Eligibility
- 18 Years to 80 Years
- Enrollment
- 70 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2015 – 2026
- U.S. locations
- 1
- States / cities
- San Francisco, California
- Conditions
- Major Depressive Disorder (MDD)
- Interventions
- SSRI (escitalopram or sertraline), Extended-Release Memantine, Placebo
- Drug
- Lead sponsor
- Jeffrey Miller
- Other
- Eligibility
- 18 Years to 50 Years
- Enrollment
- 30 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026 – 2027
- U.S. locations
- 1
- States / cities
- New York, New York
- Conditions
- Major Depressive Disorder
- Interventions
- NMRA-335140
- Drug
- Lead sponsor
- Neumora Therapeutics, Inc.
- Industry
- Eligibility
- 18 Years to 65 Years
- Enrollment
- 904 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2023 – 2026
- U.S. locations
- 126
- States / cities
- Huntsville, Alabama • Phoenix, Arizona • Bentonville, Arkansas + 94 more
- Conditions
- Pharmacogenetics, Depression - Major Depressive Disorder, Pharmacogenomic Drug Interaction, Community Pharmacy Services
- Interventions
- Comprehensive medication management with PGx testing results, Usual Care
- Other
- Lead sponsor
- University of Pittsburgh
- Other
- Eligibility
- 18 Years and older
- Enrollment
- 220 participants
- Healthy volunteers
- Healthy volunteers not accepted
- Timeline
- 2026
- U.S. locations
- 1
- States / cities
- Pittsburgh, Pennsylvania
About this Depression clinical trials directory page
- What this page lists
- U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
- How to narrow results
- Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
- Where the data comes from
- Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.
Related: all condition pages, browse by drug or therapy, browse by U.S. city, browse by sponsor, or open the full search for Depression.