Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 28, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 28, 2026, 5:56 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

5331

Shown on this page

Current sort

How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 481–492 of 5,331 matching trials for Depression.

Live ClinicalTrials.gov results.

Local aggregate panels are unavailable or hidden for filtered views. The result list above identifies its data source.

Live official records

Open in full search

Conditions: Depression
Interventions: Mom-Net, Treatment as Usual/Waitlist; Behavioral
Lead sponsor: Oregon Research Institute; Other
Eligibility: 2 Years and older
Enrollment: 960 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Springfield, Oregon

Conditions: Serious Mental Illness, Psychotic Disorder, Depression, Bipolar
Interventions: Changing Lives and Changing Outcomes-9; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Worcester, Massachusetts

Conditions: Major Depressive Disorder, Bipolar Disorder, Unipolar Major Depression
Interventions: MagPro TMS Stimulator and coil, Thymatron(R) System IV, Magnetic Resonance Imaging Scanner, ECT device without stimulation; Device · Other
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 25 Years to 64 Years
Enrollment: 8 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Treatment Resistant Depression
Interventions: Medtronic Activa PC+S System; Device
Lead sponsor: Emory University; Other
Eligibility: 25 Years to 70 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2029
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Suicide, Mental Health Disorder, Anhedonia
Interventions: ViraBrite nudges; Behavioral
Lead sponsor: Ksana Health; Industry
Eligibility: 13 Years to 18 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Suicide, Mental Health Disorder, Anhedonia
Interventions: ViraSafe: Treatment pushes, BRITE; Behavioral
Lead sponsor: Ksana Health; Industry
Eligibility: 13 Years to 24 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 3
States / cities: Eugene, Oregon • Pittsburgh, Pennsylvania

Conditions: Depression, Anxiety Disorders
Interventions: SKY Breath Intervention; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 16 Years to 24 Years
Enrollment: 14 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Depressive Disorder, Major, Borderline Personality Disorder
Interventions: Left Dorsolateral Prefrontal Cortex (L-DLPFC), Dorsomedial Prefrontal Cortex (DMPFC), Sham Stimulation; Device
Lead sponsor: Stanford University; Other
Eligibility: 18 Years to 80 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Stanford, California

Conditions: Depression, Major Depressive Disorder
Interventions: MoodTriggers Application; Other
Lead sponsor: Dartmouth-Hitchcock Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 320 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 2
States / cities: Hanover, New Hampshire • Lebanon, New Hampshire

Conditions: Osteoarthritis, Knee
Interventions: Positive Minds, Strong Joints; Behavioral
Lead sponsor: Boston University Charles River Campus; Other
Eligibility: 50 Years and older
Enrollment: 39 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Chronic Kidney Diseases, Major Depressive Disorder, End Stage Kidney Disease (ESRD)
Interventions: Bupropion, Behavioral activation therapy, Placebo, Clinical Management; Drug · Behavioral · Other
Lead sponsor: Stony Brook University; Other
Eligibility: 18 Years and older
Enrollment: 201 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2027
U.S. locations: 4
States / cities: Stony Brook, New York • Dallas, Texas • Seattle, Washington

Conditions: Anxiety, Depression, Health Knowledge, Attitudes, Practice, Stigmatization, Mobile Phone Use
Interventions: Video Intervention 1, Video Intervention 2, Video Intervention 3; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 45 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

Filter and sort this condition

Live official records

ICBT (Internet Based Cognitive Behavioral Therapy) for Maternal Depression: Community Implementation in Head Start

Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital

Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)

Deep Brain Stimulation for Treatment Resistant Depression With the Medtronic Activa PC+S

Optimizing a Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents

A Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents

SKY Breath Intervention

Treatment of Acute Mood Depressive Episode in Borderline Personality Disorder With rTMS

Remote Evaluation and Alerting for Collaborative Health (REACH) in Depression

Positive Minds Strong Joints for Knee Osteoarthritis

Combination of Novel Therapies for CKD Comorbid Depression

Mobile Mental Health Stigma Reduction Intervention Among Black Adults

About this Depression clinical trials directory page