Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 28, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 28, 2026, 7:25 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 505–516 of 5,331 matching trials for Depression.

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Live official records

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Conditions: Rheumatoid Arthritis, Sjogren's Syndrome, Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, Psoriatic Arthritis, Anxiety Disorders, Depressive Disorders, Moderate Depression, Moderate Anxiety
Interventions: Creating Health Online Course, Delayed access to Creating Health Online Course; Behavioral
Lead sponsor: Terry L. Wahls; Other
Eligibility: 18 Years to 100 Years
Enrollment: 400 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Breast Cancer, Chronic Pain, Acute Pain, Depression, Anxiety
Interventions: Questionnaires, Mechanical Temporal Summation assessment, Pain threshold assessment; Other
Lead sponsor: KK Women's and Children's Hospital; Government
Eligibility: 21 Years to 80 Years · Female only
Enrollment: 220 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Parkinson Disease, Depression
Interventions: Psilocybin, Pimavanserin; Drug
Lead sponsor: Joshua Woolley, MD, PhD; Other
Eligibility: 40 Years to 80 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Paternal Postpartum Depression, Postpartum Anxiety
Interventions: Together in Parenting; Behavioral
Lead sponsor: Women and Infants Hospital of Rhode Island; Other
Eligibility: 18 Years and older
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Depression
Interventions: Not listed
Lead sponsor: University of Michigan; Other
Eligibility: Not listed
Enrollment: 25,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2007 – 2027
U.S. locations: 1
States / cities: Ann Arbor, Michigan

Conditions: Hypersomnia
Interventions: Sleep study; Diagnostic Test
Lead sponsor: University of Pennsylvania; Other
Eligibility: 21 Years to 55 Years
Enrollment: 54 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Depressive Disorder
Interventions: Transdermal Nicotine patch; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 60 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Perinatal Depression, Postpartum Depression (PPD)
Interventions: Parents and Babies Virtual Group Intervention, Parents and Babies Hybrid Group Intervention; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 16 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Unipolar Depression
Interventions: Mindfulness practice with Tao Art (Calligraphy and Song Greatest Love), Drinking Energized water; Behavioral · Other
Lead sponsor: Sha Research Foundation; Other
Eligibility: 19 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Kahului, Hawaii

Conditions: Maternal Depression
Interventions: Problem-solving education (PSE), Engagement sessions, Usual care; Behavioral
Lead sponsor: Brown University; Other
Eligibility: Female only
Enrollment: 388 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa, Gait Impairment
Interventions: L-Dopa, Placebo; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 60 Years and older
Enrollment: 79 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania • Nashville, Tennessee

Conditions: Depression, Unipolar, Pain, Postoperative
Interventions: Mindfulness; Behavioral
Lead sponsor: University of Illinois at Urbana-Champaign; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 75 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Champaign, Illinois

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders

Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery

Psilocybin Therapy for Depression in Parkinson's Disease

Feasibility and Acceptability of a Novel Digital Intervention For Perinatal Men Who Have Depression or Anxiety

Intern Health Study

Disentangling the Role of Depression in Hypersomnia

Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension

Parents and Babies Pilot

Effect of Tao Calligraphy Meditation and Energized Water on Depression

Improving Preschool Outcomes by Addressing Maternal Depression in Head Start

Dopaminergic Dysfunction in Late-Life Depression

Maternal Mindfulness: Depression and Postpartum Pain

About this Depression clinical trials directory page