Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 25, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 25, 2026, 6:14 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 49–60 of 5,328 matching trials for Depression.

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Live official records

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Conditions: Mental Health Issue, Substance Use Disorders, Postpartum Depression, Postpartum Anxiety
Interventions: Listening to Women & Pregnant and Postpartum People; Behavioral
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 45 Years · Female only
Enrollment: 10,469 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Anxiety, Depression
Interventions: Safe and Sound Protocol, Control; Other
Lead sponsor: HealthPartners Institute; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2028
U.S. locations: 1
States / cities: Saint Paul, Minnesota

Conditions: Treatment Resistant Depression (TRD)
Interventions: Ketamine (0.25 mg/kg), Ketamine (0.5 mg/kg), Ketamine (0.75 mg/kg); Drug
Lead sponsor: Soterix Medical; Industry
Eligibility: 18 Years to 59 Years
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: New York, New York

Conditions: Traumatic Brain Injury (TBI)
Interventions: Placebo, Allopregnanolone; Drug
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 21 Years to 62 Years
Enrollment: 132 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Durham, North Carolina

Conditions: Anxiety Symptoms, Post-traumatic Stress Symptoms, Depressive Symptoms, Behavioral Problems
Interventions: RAP Club Delivered by a School Clinician, RAP Club Delivered by a Teacher, Standard Supervision, Enhanced Supervision; Behavioral
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 12 Years to 15 Years
Enrollment: 960 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2031
U.S. locations: 3
States / cities: Baltimore, Maryland

Conditions: Unipolar Depression
Interventions: transcranial direct current stimulation (tDCS) and mindfulness instruction, Sham tDCS and Mindfulness; Device
Lead sponsor: Soterix Medical; Industry
Eligibility: 22 Years and older
Enrollment: 25 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Woodbridge, New Jersey

Conditions: Perinatal Anxiety, Perinatal Depression
Interventions: Patient Navigation (PN), Problem Solving Therapy (PST); Behavioral
Lead sponsor: American University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027
U.S. locations: 1
States / cities: Austin, Texas

Conditions: Depressive Symptoms, Anxiety Disorders and Symptoms, Substance Use, Mental Health Issue
Interventions: Family Spirit Strengths (FSS), Family Spirit Nurture; Behavioral
Lead sponsor: Johns Hopkins Bloomberg School of Public Health; Other
Eligibility: 14 Years and older · Female only
Enrollment: 188 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2028
U.S. locations: 3
States / cities: Chinle, Arizona • Pokagon, Michigan • Shiprock, New Mexico

Conditions: Post Traumatic Stress Disorder, Depression - Major Depressive Disorder
Interventions: Psilocybin + MBCT therapy, Active Comparator: Psilocybin with Support Only; Combination Product
Lead sponsor: Anthony P King; Other
Eligibility: 21 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Columbus, Ohio

Conditions: Major Depressive Disorder
Interventions: Open-label TMS; Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 18 Years to 65 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Los Angeles, California

Conditions: Mood Disorder
Interventions: Not listed
Lead sponsor: National Institute of Mental Health (NIMH); NIH
Eligibility: 40 Years to 65 Years · Female only
Enrollment: 1,158 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: Started 1989
U.S. locations: 1
States / cities: Bethesda, Maryland

Conditions: Major Depressive Disorder
Interventions: Placebo, intermittent theta burst stimulation, intravenous citalopram hydrochloride (CIT), continuous theta burst stimulation; Drug · Device
Lead sponsor: University of California, Los Angeles; Other
Eligibility: 21 Years to 55 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2017 – 2028
U.S. locations: 1
States / cities: Los Angeles, California

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

Filter and sort this condition

Live official records

Improving Maternal Mental Health & SUD Screening and Treatment

The Effect of the Safe and Sound Protocol on Depression and Anxiety Symptoms

Ketamine Biomarker Validation

Allopregnanolone in Chronic Complex Traumatic Brain Injury

Improving Student Mental Health Through a Universal Trauma-Informed Intervention

Transcranial Direct Current Stimulation for Depression

Improving Perinatal Mental Health Through a Collaborative, Community Health Worker and Social Worker Intervention

Family Spirit Strengths

Mindfulness-based Psilocybin Therapy for PTSD

In-patient SCC TMS

Perimenopause-Related Mood and Behavioral Disorders

Effects of Intravenous (IV) Citalopram Hydrochloride During Transcranial Magnetic Stimulation in Major Depressive Disorder (MDD)

About this Depression clinical trials directory page