Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 6, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 6, 2026, 10:55 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

428

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 61–72 of 428 matching trials for Depression.

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Conditions: Treatment Resistant Depression, Inflammation, Overweight
Interventions: Omega 3, Placebo; Drug · Other
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 14 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 3
States / cities: Atlanta, Georgia • Boston, Massachusetts • Salt Lake City, Utah

Conditions: Major Depressive Disorder
Interventions: Intermittent Theta Burst Stimulation (iTBS), Transcranial Alternating Current Stimulation (tACS), Psychotherapy, Sham (Placebo) Transcranial Alternating Current Stimulation (tACS); Device · Behavioral
Lead sponsor: University of North Carolina, Chapel Hill; Other
Eligibility: 18 Years to 70 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Chapel Hill, North Carolina

Conditions: Cancer in Remission (Any Type or Stage), Depression, Anxiety
Interventions: Repetitive Transcranial Magnetic Stimulation (rTMS); Device
Lead sponsor: Northwestern University; Other
Eligibility: 22 Years to 80 Years
Enrollment: 24 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2023
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Major Depressive Disorder
Interventions: Deep Brain Stimulation; Device
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 37 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2006 – 2024
U.S. locations: 1
States / cities: Atlanta, Georgia

Conditions: Major Depressive Disorder, Bipolar Depression
Interventions: Xenon, Nitrogen gas; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 65 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Major Depressive Disorder, Treatment Resistant Depression
Interventions: Medtronic Summit RC+S DBS system; Device
Lead sponsor: Helen Mayberg, MD; Other
Eligibility: 25 Years to 70 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2030
U.S. locations: 1
States / cities: New York, New York

Conditions: Treatment Resistant Depression
Interventions: Vagus Nerve Stimulation (VNS); Device
Lead sponsor: LivaNova; Industry
Eligibility: 18 Years and older
Enrollment: 6,800 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2030
U.S. locations: 101
States / cities: Birmingham, Alabama • Huntsville, Alabama • Burlingame, California + 85 more

Conditions: Treatment Resistant Depression
Interventions: Aerobic Exercise, Video Watching; Behavioral
Lead sponsor: Butler Hospital; Other
Eligibility: 18 Years and older
Enrollment: 26 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Providence, Rhode Island

Conditions: Intolerance of Uncertainty, Anxiety, Intolerance of Uncertainty; Anxiety, Depression, Anxiety
Interventions: Uncertainty-focused single session intervention, Maintaining a healthy lifestyle single session intervention; Behavioral
Lead sponsor: Northwestern University; Other
Eligibility: 25 Years to 60 Years
Enrollment: 140 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Major Depressive Disorder, Anhedonia, Treatment Resistant Depression
Interventions: Psilocybin 25mg, Placebo (active placebo); Drug
Lead sponsor: University of Colorado, Denver; Other
Eligibility: 21 Years to 75 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Aurora, Colorado

Conditions: Depression
Interventions: Psilocybin (Usona Institute); Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 50 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2031
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Postpartum Depression, Postpartum Anxiety, Cardiometabolic Syndrome
Interventions: MOMI PODS, Enhanced Usual Care (EUC); Behavioral
Lead sponsor: Ohio State University; Other
Eligibility: Female only
Enrollment: 384 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2024 – 2028
U.S. locations: 1
States / cities: Columbus, Ohio

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression

CARED : A Novel Rapid Treatment Paradigm for Depression

Repetitive Transcranial Magnetic Stimulation in Cancer Patients With Depression and Anxiety

Deep Brain Stimulation for Treatment Resistant Depression

Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder

DBS for TRD With the Medtronic Summit RC+S

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

Exercise to Augment TMS in Those With Treatment Resistant Depression

Test of Target Engagement of Ambiguity Aversion

Psilocybin for Treatment-Resistant Depression

Psilocybin-Assisted Therapy as a Treatment for Depression

The Mom and Infant Outcomes (MOMI) Study

About this Depression clinical trials directory page