Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 29, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 29, 2026, 4:30 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 781–792 of 5,333 matching trials for Depression.

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Live official records

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Conditions: Symptoms of Depression
Interventions: Exercise and virtual reality, Riding a cycle ergometer; Device · Other
Lead sponsor: The University of Texas at Arlington; Other
Eligibility: 18 Years to 65 Years
Enrollment: 200 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 1
States / cities: Arlington, Texas

Conditions: Depression in Adolescence, Suicidal Ideation, Social Media Addiction, Mental Health Issue
Interventions: Not listed
Lead sponsor: University of Texas Southwestern Medical Center; Other
Eligibility: 13 Years to 18 Years
Enrollment: 100 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Dallas, Texas

Conditions: Testicular Cancer
Interventions: Goal-focused Emotion-regulation Therapy; Behavioral
Lead sponsor: University of California, Irvine; Other
Eligibility: 18 Years to 39 Years · Male only
Enrollment: 35 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 1
States / cities: Irvine, California

Conditions: Stress Disorders, Post-Traumatic, Depressive Disorder, Anxiety Disorders, Substance-Related Disorders
Interventions: Omnis Salutis, Health and Wellness; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years to 65 Years
Enrollment: 238 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2026
U.S. locations: 2
States / cities: Aurora, Colorado • Baltimore, Maryland

Conditions: Caregiver Burden, Well-Being, Psychological, Stress, Psychological, Depression, Anxiety
Interventions: Not listed
Lead sponsor: University of Alabama at Birmingham; Other
Eligibility: 18 Years to 100 Years
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Birmingham, Alabama

Conditions: Wellness, Quality of Life, Anxiety, Depression
Interventions: Caravan Wellness app; Device
Lead sponsor: Yale University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 120 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2027
U.S. locations: 1
States / cities: New Haven, Connecticut

Conditions: Depression, Anxiety, Psychological Distress, PTSD
Interventions: Problem Management Plus, Services as Usual; Behavioral
Lead sponsor: George Washington University; Other
Eligibility: 18 Years and older
Enrollment: 1,206 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2026
U.S. locations: 1
States / cities: New York, New York

Conditions: Major Depressive Disorder, Depression, Healthy
Interventions: SP-624, Placebo; Drug
Lead sponsor: Sirtsei Pharmaceuticals, Inc.; Industry
Eligibility: 18 Years to 60 Years
Enrollment: 26 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Garden Grove, California • Lincoln, Nebraska

Conditions: Alcohol; Use, Problem, Stress, Binge Eating, Depression
Interventions: behavioral activation; Behavioral
Lead sponsor: University of Kansas; Other
Eligibility: 17 Years and older
Enrollment: 572 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2025
U.S. locations: 1
States / cities: Lawrence, Kansas

Conditions: Lung Cancer (Diagnosis), Anxiety, Depression in Adults
Interventions: High Touch Outreach; Behavioral
Lead sponsor: Abramson Cancer Center at Penn Medicine; Other
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Philadelphia, Pennsylvania

Conditions: Post Operative Delirium, Cognitive Impairment, Vagus Nerve Stimulation, Depression
Interventions: Transcutaneous vagal nerve stimulation, Sham (No Treatment); Device
Lead sponsor: Northwestern University; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: HIV, Depression, Anhedonia
Interventions: Baricitinib, Placebo; Drug · Other
Lead sponsor: Emory University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 2
States / cities: Atlanta, Georgia

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

Effects of Exercise and Virtual Reality on Depression

Social Media Concerns Related to Emotional Experiences in Naturalistic Settings (SCREENS)

Young Adult Latino Testicular Cancer Survivors: a Pilot Study of Goal-Focused Emotion Regulation Therapy (GET)

Whole Health in VA Mental Health: Omnis Salutis

The Nuestros Días ("Our Days") Study

Assessing the Effectiveness of Digital Wellness Modules on Perceived Quality of Life

REstoring Mental Health Through COmmUnity-based Psychological Services in New York City

A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major Depression

A Behavioral Activation Intervention Administered in a College Freshman Orientation Course

Telehealth Collaborative Care Model (CoCM) in Lung Cancer

Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression

Inflammation and Depression in People With HIV

About this Depression clinical trials directory page