Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 29, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 29, 2026, 4:26 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 877–888 of 5,335 matching trials for Depression.

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Live official records

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Conditions: Premenstrual Dysphoric Disorder (PMDD)
Interventions: sertraline 50 mg daily, Placebo Oral Tablet; Drug
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 288 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 2
States / cities: Baltimore, Maryland • Charlottesville, Virginia

Conditions: PMDD, Premenstrual Dysphoric Disorder (PMDD), Premenstrual Syndrome-PMS, Premenstrual Syndrome, Menstrual Cycle
Interventions: Not listed
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 500 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2031
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Trauma-related Mental Health Symptoms
Interventions: Calm Moms-V, Care As Usual; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: Female only
Enrollment: 36 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2030
U.S. locations: 1
States / cities: New Orleans, Louisiana

Conditions: PTSD, Depression, Child Maltreatment
Interventions: P-STAIR, Supportive Counseling; Behavioral
Lead sponsor: New York University; Other
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: New York, New York

Conditions: Post Traumatic Stress Disorder, Depression, Violence
Interventions: BSHAPE, Control (general wellness); Behavioral · Other
Lead sponsor: Johns Hopkins University; Other
Eligibility: 18 Years and older · Female only
Enrollment: 676 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2028
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Major Depression
Interventions: Psilocybin (Usona Institute), Propofol, Placebo; Drug
Lead sponsor: Stanford University; Other
Eligibility: 25 Years to 65 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2027
U.S. locations: 1
States / cities: Stanford, California

Conditions: Cancer, Major Depressive Disorder
Interventions: Psilocybin, Placebo; Drug
Lead sponsor: Sunstone Medical; Other
Eligibility: 18 Years and older
Enrollment: 56 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: Rockville, Maryland

Conditions: Opioid Use Disorder, Substance Use Disorders, Medication Assisted Treatment
Interventions: Minds and Mentors, Twelve Step Intervention Group; Behavioral
Lead sponsor: University of Alabama, Tuscaloosa; Other
Eligibility: 19 Years and older
Enrollment: 240 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2027
U.S. locations: 4
States / cities: Birmingham, Alabama • Tuscaloosa, Alabama

Conditions: Depression
Interventions: Rejection and Acceptance Feedback; Behavioral
Lead sponsor: University of Pittsburgh; Other
Eligibility: 13 Years to 17 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Pittsburgh, Pennsylvania

Conditions: Depression
Interventions: BrainSonix Pulsar 1002; Device
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 80 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2026
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Alzheimer Disease, Major Depressive Disorder
Interventions: Escitalopram Oxalate, Placebo; Drug
Lead sponsor: NYU Langone Health; Other
Eligibility: 60 Years and older
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2027
U.S. locations: 2
States / cities: New York, New York • Orangeburg, New York

Conditions: Depression, Brain Injuries, Traumatic
Interventions: Buspirone, Mealatonin; Drug
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 18 Years to 64 Years
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2028
U.S. locations: 2
States / cities: Boston, Massachusetts • Charlestown, Massachusetts

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

Allopregnanolone and Dynamic GABA-A Receptor Plasticity in Selective Serotonin Reuptake Inhibitor Responsive Premenstrual Dysphoric Disorder

Identification and Validation of Epigenetic Biomarkers of PMDD

Adaptation and Examination of a Trauma-informed Intervention for Pregnant Veterans

Safe Mothers, Safe Children Initiative

Being Safe, Healthy, And Positively Empowered (BSHAPE) Intervention Study

Study of Psilocybin Under Anesthesia Controlled by EEG

Two Doses of Psilocybin for the Treatment of MDD in Adults With Cancer

Minds and Mentors Program- R33

Teen Brain Online II: Understanding How Social Media Affects the Teen Brain

Neuromodulation of Mind-Wandering in Depression

Aβ Dynamics in LLMD

Buspirone and Melatonin for Depression Following Traumatic Brain Injury

About this Depression clinical trials directory page