Condition Directory

Depression clinical trials

Directory of U.S. ClinicalTrials.gov public records for Depression. Browse Depression recruiting trials, filter by phase, sponsor, location, or intervention, and open the official ClinicalTrials.gov study record for each result.

By Clinical Trials Finder Guidance last reviewed June 10, 2026 Data synced October 30, 2026 Report an issue

ClinicalTrials.gov public records Last synced Oct 29, 2026, 9:11 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

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How Depression studies are organized in the registry

Most records use the formal term “major depressive disorder” or MDD rather than “depression” alone, and “treatment-resistant depression” (TRD) labels a distinct, sizable subset. The portfolio includes many behavioral, digital, and device interventions, so the intervention and study-type filters do real work here.

Terms that often appear in related listings

major depressive disorder treatment-resistant depression MDD digital intervention

These describe how studies tend to be titled and grouped on ClinicalTrials.gov — they are search vocabulary, not medical guidance.

Showing 961–972 of 5,335 matching trials for Depression.

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Live official records

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Conditions: Depressive Disorder, Major
Interventions: Psilocybin, Niacin, Set and Setting (SaS) Protocol; Drug · Other
Lead sponsor: Usona Institute; Other
Eligibility: 21 Years to 65 Years
Enrollment: 347 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2022
U.S. locations: 11
States / cities: San Francisco, California • Santa Monica, California • New Haven, Connecticut + 8 more

Conditions: Insulin Resistance, Depression, Depressive Disorder, Mood Disorders, Mental Disorder in Adolescence, Hyperinsulinism, Glucose Metabolism Disorders, Metabolic Disease
Interventions: Cognitive-Behavioral Therapy followed by Exercise Training, Exercise Training followed by Cognitive-Behavioral Therapy, Cognitive-Behavioral Therapy Only, Exercise Training Only; Behavioral
Lead sponsor: Colorado State University; Other
Eligibility: 12 Years to 17 Years · Female only
Enrollment: 300 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2029
U.S. locations: 2
States / cities: Aurora, Colorado • Fort Collins, Colorado

Conditions: PTSD, Depression
Interventions: PATH-SS; Behavioral
Lead sponsor: Case Western Reserve University; Other
Eligibility: 18 Years to 65 Years
Enrollment: 45 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Cleveland, Ohio

Conditions: Depression
Interventions: After School Plus; Behavioral
Lead sponsor: University of Minnesota; Other
Eligibility: 9 Years to 99 Years
Enrollment: 209 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Major Depressive Disorder
Interventions: Transcranial direct current stimulation, Sham Transcranial direct current stimulation; Device
Lead sponsor: Flow Neuroscience AB; Industry
Eligibility: 18 Years and older
Enrollment: 174 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 1
States / cities: Houston, Texas

Conditions: Communication, Anxiety, Depression, Distress, Emotional
Interventions: VCHIPS; Other
Lead sponsor: Indiana University; Other
Eligibility: 65 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Major Depressive Disorder
Interventions: LPS, Saline; Biological
Lead sponsor: Laureate Institute for Brain Research, Inc.; Other
Eligibility: 18 Years to 65 Years
Enrollment: 180 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2026
U.S. locations: 1
States / cities: Tulsa, Oklahoma

Conditions: Depression, Anxiety, Physical Disability
Interventions: Positive Minds Strong Bodies Enhanced, Enhanced Usual Care; Behavioral
Lead sponsor: Massachusetts General Hospital; Other
Eligibility: 60 Years and older
Enrollment: 427 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2024
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Schizophrenia, Treatment Resistant Depression, Aging, Premature
Interventions: Dasatinib, quercetin; Drug
Lead sponsor: Washington University School of Medicine; Other
Eligibility: 50 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2023 – 2027
U.S. locations: 1
States / cities: St Louis, Missouri

Conditions: Major Depressive Disorder
Interventions: Interpersonal psychotherapy for major depression following perinatal loss, Coping with Depression; Behavioral
Lead sponsor: Michigan State University; Other
Eligibility: 18 Years to 50 Years · Female only
Enrollment: 199 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2025
U.S. locations: 1
States / cities: Flint, Michigan

Conditions: Maternal Depression, Child Behavior Problem
Interventions: Attachment and Biobehavioral Catch up, Attachment and Biobehavioral Catch up Plus Depression Treatment; Behavioral
Lead sponsor: University of California, San Francisco; Other
Eligibility: 2 Years and older · Female only
Enrollment: 76 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: San Francisco, California

Conditions: Depression
Interventions: Behavioral Activation-Guided Self-Help; Behavioral
Lead sponsor: VA Office of Research and Development; Federal
Eligibility: 18 Years and older
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2027 – 2031
U.S. locations: 1
States / cities: Houston, Texas

About this Depression clinical trials directory page

What this page lists: U.S. ClinicalTrials.gov public records that list Depression as a study condition, including recruiting, not yet recruiting, and active not recruiting trials across phase 1, phase 2, and phase 3.
How to narrow results: Use the filters above to scope by intervention, sponsor, city, state, recruitment status, phase, study type, healthy volunteer eligibility, sex, age, or NCT ID within Depression.
Where the data comes from: Records are sourced from the official ClinicalTrials.gov public API. Each result links back to the official study page, which is the source of truth for eligibility, enrollment, and contact information.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, ranking of trials by quality, or AI-generated medical summaries.

Depression clinical trials

How Depression studies are organized in the registry

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Live official records

A Study of Psilocybin for Major Depressive Disorder (MDD)

Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

Positive Processes and Transition to Health - Single-Session (PATH-SS)

Using a Mentoring Afterschool Program to Improve Adolescent Mental Health and Physical Activity: A Pilot Study

Empower: tDCS for Major Depressive Disorder at Home

Virtual Communication in the Hospital: Impact on Patients and Surrogates

Neural Response to Inflammatory Challenge in Major Depressive Disorder

Positive Minds Strong Bodies Implementation

Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders

IPT for Major Depression Following Perinatal Loss: Healing After Loss (HeAL)

Attachment and Biobehavioral Catch-up and Depression Treatment

Pilot Randomized Trial of BA-GSH in VA PC-MHI

About this Depression clinical trials directory page