Healthy Volunteer Hub

Healthy volunteer clinical trials in the U.S.

This page focuses on public ClinicalTrials.gov records that explicitly say they accept healthy volunteers. It starts with recruiting studies by default, and it does not guess the visitor's location. Add a city or state only when you want location-specific results before checking the official study record.

These results were retrieved from the live ClinicalTrials.gov registry. Filters and sort order apply to this result list.

ClinicalTrials.gov public records Last synced Oct 19, 2026, 7:42 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official matching trials

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Recruiting

The default view starts with recruiting studies because those are usually the most actionable.

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Live official records

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Conditions: Treatment for Opioid Use Disorder
Interventions: Train and evaluate the accuracy and reliability of the Strength Band Platform in identifying acute opioid dosing events from time-stamped biometric data collected from wrist-worn devices.; Device
Lead sponsor: OpiAID; Industry
Eligibility: 22 Years and older
Enrollment: 420 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2027
U.S. locations: 1
States / cities: Wilmington, North Carolina

Conditions: Exercise Recovery, Physical Performance Parameters, Muscle Damage, Cognition, Blood Biomarkers, Stress
Interventions: Pork-Based Protein Ready-to-Eat Meals, Plant-Based Protein Ready-to-Eat Meals, Carbohydrate-Focused Lower-Protein Ready-to-Eat Meals; Other
Lead sponsor: Sam Houston State University; Other
Eligibility: 18 Years to 60 Years
Enrollment: 20 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 2
States / cities: Fort Worth, Texas • Huntsville, Texas

Conditions: Healthy Volunteer
Interventions: Emraclidine, Placebo; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 65 Years to 85 Years
Enrollment: 52 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 5
States / cities: Cypress, California • Maitland, Florida • Miami, Florida + 2 more

Conditions: Brain Tumor, Brain Necrosis, Brain Metastases, Glioma
Interventions: MRF in conjunction with IVIM MRI without contrast; Procedure
Lead sponsor: Case Comprehensive Cancer Center; Other
Eligibility: 18 Years to 60 Years
Enrollment: 90 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Cleveland, Ohio

Conditions: Immunization, HPV Infection, Human Papillomavirus
Interventions: 9-valent HPV vaccine, 2 doses alternate timing, 9-valent HPV vaccine, 3 doses standard timing; Biological
Lead sponsor: The University of Texas Medical Branch, Galveston; Other
Eligibility: 27 Years to 45 Years · Female only
Enrollment: 618 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2023 – 2028
U.S. locations: 1
States / cities: Galveston, Texas

Conditions: Healthy, Major Depressive Disorder, Treatment Resistant Depression
Interventions: Ketamine, Saline; Drug · Other
Lead sponsor: Texas A&M University; Other
Eligibility: 21 Years to 45 Years
Enrollment: 100 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 2
States / cities: Houston, Texas

Conditions: Pneumococcal Disease
Interventions: PG4, 20-valent pneumococcal conjugate vaccine (20vPnC); Biological
Lead sponsor: Pfizer; Industry
Eligibility: 42 Days to 98 Days
Enrollment: 2,400 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 23
States / cities: Estero, Florida • Fort Lauderdale, Florida • Fort Myers, Florida + 16 more

Conditions: Barrett Esophagus, Gastroesophageal Reflux, Esophageal Adenocarcinoma
Interventions: EsoCheck, EsoGuard; Device · Diagnostic Test
Lead sponsor: Case Comprehensive Cancer Center; Other
Eligibility: 50 Years and older
Enrollment: 800 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2029
U.S. locations: 5
States / cities: Aurora, Colorado • Baltimore, Maryland • Chapel Hill, North Carolina + 1 more

Conditions: Athlete Support
Interventions: Not listed
Lead sponsor: Pennington Biomedical Research Center; Other
Eligibility: 18 Years and older
Enrollment: 250 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2026
U.S. locations: 1
States / cities: Baton Rouge, Louisiana

Conditions: Healthy Volunteers, Influenza
Interventions: Flu H5 egg pandemic low dose vaccine, with adjuvant, Flu H5 Egg Pandemic medium dose vaccine, with adjuvant, Flu H5 Egg Pandemic high dose vaccine, with adjuvant, Flu H5 Egg Pandemic high dose vaccine, without adjuvant; Biological
Lead sponsor: Sanofi; Industry
Eligibility: 18 Years and older
Enrollment: 640 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2028
U.S. locations: 16
States / cities: Tempe, Arizona • Rolling Hills Estates, California • San Diego, California + 12 more

Conditions: Gestational Diabetes Mellitus (GDM), Diabetes Type 2, Breastfeeding Continuation, Breastfeeding Support
Interventions: Implementation mapping to develop a multilevel health system strategy for prevention of type 2 diabetes through targeted breastfeeding support for patients with gestational diabetes; Other
Lead sponsor: University of California, Davis; Other
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026
U.S. locations: 1
States / cities: Sacramento, California

Conditions: Epilepsy
Interventions: SeizEAR; Device
Lead sponsor: Icahn School of Medicine at Mount Sinai; Other
Eligibility: 18 Years to 70 Years
Enrollment: 15 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: New York, New York

Healthy volunteer clinical trials in the U.S.

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A Study to Train a Machine Learning Algorithm for an Evaluation of the Use of Biometric Data Captured at the Wrist for the Identification of Acute Opioid Use Events and the Quantification of Opioid Withdrawal in Opioid Dependent Individuals

Effects of Pork Protein on Recovery Following Simulated Fireground Activity

A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants

Development of MRF for Characterization of Brain Tumors After Radiotherapy

Comparing Immune Response of 2 vs 3 HPV Doses (27-45 Years Old)

Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression

A Study to Learn About the Safety of an Expanded Pneumococcal Vaccine in Healthy Infants

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

Athlete Needs Assessment & Focus Groups

Study to Assess Safety and Immunogenicity of an Egg-based H5N8 Influenza Vaccine at Multiple Dose Levels Adjuvanted With Matrix-M in Healthy Participants 18 Years of Age and Above.

Pregnancy and Postpartum Breastfeeding Support for Patients With Gestational Diabetes

SeizEAR Safety Study