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ClinicalTrials.gov public records Last synced Oct 19, 2026, 5:04 AM EDT

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Showing 361–384 of 498 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Acid Reflux Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

NCT03961945
View directory record Official record
Conditions
Barrett Esophagus, Esophageal Adenocarcinoma
Interventions
Sponge Capsule
Device
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years to 90 Years
Enrollment
1,526 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2025
U.S. locations
8
States / cities
Scottsdale, Arizona • Jacksonville, Florida • Austin, Minnesota + 5 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2026 · Synced Oct 19, 2026, 5:04 AM EDT
Withdrawn Not applicable Interventional

(ARFI) Shear Velocity Imaging of the Kidneys in Pediatric Patients

NCT01781819
View directory record Official record
Conditions
Urine Reflux, Kidney Damage
Interventions
ARFI SVI Ultrasound Imaging
Procedure
Lead sponsor
University of Michigan
Other
Eligibility
Up to 18 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Jun 1, 2015 · Synced Oct 19, 2026, 5:04 AM EDT
Completed Phase 3 Interventional Results available

Phase 3/Safety & Efficacy of Esomeprazole in Infants

NCT00468559
View directory record Official record
Conditions
Gastroesophageal Reflux Disease (GERD)
Interventions
Open Label Run In Esomeprazole, Double Blind Esomeprazole, Double Blind Placebo
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
1 Month to 11 Months
Enrollment
98 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2008
U.S. locations
14
States / cities
Phoenix, Arizona • Atlanta, Georgia • Park Ridge, Illinois + 11 more
Source: ClinicalTrials.gov public record
Updated Jun 2, 2014 · Synced Oct 19, 2026, 5:04 AM EDT
Completed Not applicable Interventional Results available

Carpentier-Edwards PERIMOUNT Magna Ease Pericardial Bioprosthesis, Model 3300TFX

NCT01171625
View directory record Official record
Conditions
Coronary Artery Disease, Aortic Valve Disorder, Heart Failure, Aortic Valve Stenosis, Aortic Valve Insufficiency
Interventions
Implantation of CEP Magna Ease Model 3300TFX
Device
Lead sponsor
Edwards Lifesciences
Industry
Eligibility
18 Years and older
Enrollment
283 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2018
U.S. locations
5
States / cities
Sacramento, California • Camden, New Jersey • Morristown, New Jersey + 2 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2020 · Synced Oct 19, 2026, 5:04 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Sensory Evaluation of Dexlansoprazole Delayed-Release Orally Disintegrating Tablets

NCT02096458
View directory record Official record
Conditions
Gastroesophageal Reflux Disease, Erosive Esophagitis, Heartburn
Interventions
Dexlansoprazole
Drug
Lead sponsor
Takeda
Industry
Eligibility
25 Years to 80 Years
Enrollment
8 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014
U.S. locations
1
States / cities
Woburn, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 6, 2015 · Synced Oct 19, 2026, 5:04 AM EDT
Completed Not applicable Interventional Results available

Neonatal Gastro-Esophageal Reflux Disease (GERD) Management Trial

NCT02486263
View directory record Official record
Conditions
Gastroesophageal Reflux Disease
Interventions
Study Arm - acid suppression plus feeding bundle, Conventional arm - acid suppression only
Other
Lead sponsor
Sudarshan Jadcherla
Other
Eligibility
34 Weeks to 60 Weeks
Enrollment
76 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2020
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Jul 29, 2020 · Synced Oct 19, 2026, 5:04 AM EDT
Completed Phase 2 Interventional Results available

Selective 5-HT4 Receptor Agonist and Proton Pump Inhibitor (PPI) in Subjects With Gastroesophageal Reflux Disease (GERD)

NCT01472939
View directory record Official record
Conditions
Gastroesophageal Reflux Disease
Interventions
SSP-002358 (0.1 mg) + PPI, SSP-002358 (0.5 mg) + PPI, SSP-002358 (2.0 mg) + PPI, Placebo + PPI
Drug
Lead sponsor
Shire
Industry
Eligibility
18 Years to 70 Years
Enrollment
480 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
62
States / cities
Phoenix, Arizona • Tucson, Arizona • Little Rock, Arkansas + 58 more
Source: ClinicalTrials.gov public record
Updated Jun 9, 2021 · Synced Oct 19, 2026, 5:04 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Screening for Barrett's Esophagus in Otolaryngology Patients

NCT00695227
View directory record Official record
Conditions
Extraesophageal Symptoms, Cough, Throat Clearing, Hoarseness, Difficulty Swallowing
Interventions
Screening for Barrett's Esophagus
Diagnostic Test
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Eligibility
18 Years to 90 Years
Enrollment
295 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2004 – 2011
U.S. locations
1
States / cities
Portland, Oregon
Source: ClinicalTrials.gov public record
Updated Mar 6, 2018 · Synced Oct 19, 2026, 5:04 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Study of an Oropharyngeal Aerosolized pH Probe for Diagnosing Laryngopharyngeal Reflux (LPR)

NCT00321503
View directory record Official record
Conditions
Laryngopharyngeal Reflux
Interventions
Not listed
Lead sponsor
Emory University
Other
Eligibility
18 Years and older
Enrollment
45 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2006 – 2007
U.S. locations
1
States / cities
Atlanta, Georgia
Source: ClinicalTrials.gov public record
Updated Dec 9, 2013 · Synced Oct 19, 2026, 5:04 AM EDT
Completed Not applicable Interventional Results available

Genotype-supported Versus Conventional Proton Pump Inhibitor Dosing

NCT02930824
View directory record Official record
Conditions
Gastroesophageal Reflux Disease
Interventions
CYP2C19 genotyping
Genetic
Lead sponsor
University of Florida
Other
Eligibility
5 Years to 100 Years
Enrollment
185 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2019
U.S. locations
2
States / cities
Gainesville, Florida • Orlando, Florida
Source: ClinicalTrials.gov public record
Updated May 16, 2024 · Synced Oct 19, 2026, 5:04 AM EDT
Terminated Not applicable Interventional

Hiatal Interrogation in Sleeve Gastrectomy

NCT03527810
View directory record Official record
Conditions
Sleeve Gastrectomy
Interventions
Sleeve Gastrectomy Without Interrogation of Hiatus, Sleeve Gastrectomy With Interrogation of Hiatus
Procedure
Lead sponsor
Miguel Burch
Other
Eligibility
18 Years and older
Enrollment
16 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Apr 1, 2022 · Synced Oct 19, 2026, 5:04 AM EDT
Completed Phase 1 Interventional

A Pharmacokinetics, Pharmacodynamics and Safety Study of Rabeprazole in New Born Infants With Gastroesophageal Reflux Disease (GERD)

NCT00855361
View directory record Official record
Conditions
Gastroesophageal Reflux
Interventions
Rabeprazole sodium
Drug
Lead sponsor
Janssen Research & Development, LLC
Industry
Eligibility
Up to 44 Weeks
Enrollment
69 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2011
U.S. locations
10
States / cities
Orange, California • Washington D.C., District of Columbia • Augusta, Georgia + 7 more
Source: ClinicalTrials.gov public record
Updated Apr 29, 2013 · Synced Oct 19, 2026, 5:04 AM EDT
Recruiting No phase listed Observational

The Role of Laryngopharyngeal Reflux in IPF

NCT03418350
View directory record Official record
Conditions
IPF, Reflux
Interventions
Not listed
Lead sponsor
National Jewish Health
Other
Eligibility
40 Years to 95 Years
Enrollment
60 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2026
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Nov 14, 2024 · Synced Oct 19, 2026, 5:04 AM EDT
Terminated Not applicable Interventional

Quantifying Effects of Treatment of Pediatric Dysphonia

NCT00237679
View directory record Official record
Conditions
Voice Disorders, Gastroesophageal Reflux
Interventions
Neuromuscular Electrical Stimulation, Unstimulated
Behavioral
Lead sponsor
University of Wisconsin, Madison
Other
Eligibility
6 Years to 11 Years
Enrollment
31 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2008
U.S. locations
1
States / cities
Madison, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 14, 2015 · Synced Oct 19, 2026, 5:04 AM EDT
Terminated Not applicable Interventional

Registry Study of the NDO Surgical Plicator for the Treatment of GERD

NCT00597792
View directory record Official record
Conditions
GERD
Interventions
NDO Full-thickness Plicator
Device
Lead sponsor
NDO Surgical, Inc.
Industry
Eligibility
18 Years and older
Enrollment
131 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2007
U.S. locations
7
States / cities
Macon, Georgia • Evanston, Illinois • Indianapolis, Indiana + 4 more
Source: ClinicalTrials.gov public record
Updated May 30, 2008 · Synced Oct 19, 2026, 5:04 AM EDT
Completed Phase 2 Interventional Results available

YF476 in Barrett's Esophagus

NCT02597712
View directory record Official record
Conditions
Barrett's Esophagus
Interventions
YF476, YF476 placebo
Drug
Lead sponsor
Trio Medicines Ltd.
Industry
Eligibility
18 Years and older
Enrollment
27 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2017
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Apr 12, 2021 · Synced Oct 19, 2026, 5:04 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pepsin As A Biomarker For Aspiration

NCT00865995
View directory record Official record
Conditions
Aspiration, Gastroesophageal Reflux
Interventions
Tracheal Lavage
Procedure
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
1 Year to 18 Years
Enrollment
76 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2008 – 2012
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Oct 23, 2013 · Synced Oct 19, 2026, 5:04 AM EDT
Withdrawn Not applicable Interventional Accepts healthy volunteers

Nasopharyngeal 24 Hour pH Monitoring in Health Adult Volunteers

NCT00584675
View directory record Official record
Conditions
Gastroesophageal Reflux Disease
Interventions
Dx-pH Measurement Probe
Device
Lead sponsor
University of California, Davis
Other
Eligibility
18 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2007 – 2008
U.S. locations
1
States / cities
Sacramento, California
Source: ClinicalTrials.gov public record
Updated Jun 19, 2015 · Synced Oct 19, 2026, 5:04 AM EDT
Completed Not applicable Interventional Results available

The RELIEF™ Ureteral Stent - Assessment of Retrograde Urinary Reflux and Distal Coil Bladder Position

NCT03266770
View directory record Official record
Conditions
Ureteral Obstruction
Interventions
RELIEF Stent
Device
Lead sponsor
University Hospitals Cleveland Medical Center
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Feb 1, 2024 · Synced Oct 19, 2026, 5:04 AM EDT
Recruiting Not applicable Interventional

Viome Nutritional Programs to Improve Clinical Outcomes for Gastrointestinal Conditions

NCT05465629
View directory record Official record
Conditions
Gastrointestinal Health
Interventions
VIOME Precision Nutrition Program, VIOME-designed condition-based supplements
Combination Product · Dietary Supplement
Lead sponsor
Viome
Industry
Eligibility
25 Years to 75 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Bothell, Washington
Source: ClinicalTrials.gov public record
Updated Jan 29, 2025 · Synced Oct 19, 2026, 5:04 AM EDT
Completed Phase 2 Interventional

Post-nasal Drainage as an Extraesophageal Manifestation of Reflux

NCT00199953
View directory record Official record
Conditions
Postnasal Drainage
Interventions
Rabeprazole 20 mg twice a day for 90-day period treatment
Drug
Lead sponsor
Medical College of Wisconsin
Other
Eligibility
18 Years to 70 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2002 – 2007
U.S. locations
1
States / cities
Milwaukee, Wisconsin
Source: ClinicalTrials.gov public record
Updated Jan 30, 2017 · Synced Oct 19, 2026, 5:04 AM EDT
Terminated No phase listed Observational

Gastroesophageal Reflux Disease Prospective Registry

NCT02479438
View directory record Official record
Conditions
GERD
Interventions
Diagnosed with GERD
Other
Lead sponsor
Baylor Research Institute
Other
Eligibility
18 Years and older
Enrollment
744 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2014 – 2024
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated May 22, 2025 · Synced Oct 19, 2026, 5:04 AM EDT
Terminated Not applicable Interventional

Prospective Evaluation of Symptom Resolution in Acid Versus Non-acid Reflux Disease Following Anti-reflux Surgery

NCT01241149
View directory record Official record
Conditions
Non-acid Reflux Disease
Interventions
anti-reflux surgery
Procedure
Lead sponsor
United States Naval Medical Center, Portsmouth
Federal
Eligibility
17 Years and older
Enrollment
12 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2014
U.S. locations
1
States / cities
Portsmouth, Virginia
Source: ClinicalTrials.gov public record
Updated Aug 15, 2025 · Synced Oct 19, 2026, 5:04 AM EDT
Completed Phase 2 Interventional Results available

Investigate the Effect of Different Doses of Lesogaberan (AZD3355) as add-on to PPI in GERD Patients With Partial Response to PPI

NCT01005251
View directory record Official record
Conditions
Gastroesophageal Reflux Disease, Heartburn, Regurgitation
Interventions
lesogaberan (AZD3355), Placebo
Drug
Lead sponsor
AstraZeneca
Industry
Eligibility
18 Years to 70 Years
Enrollment
661 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Apr 25, 2011 · Synced Oct 19, 2026, 5:04 AM EDT