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ClinicalTrials.gov public records Last synced Nov 13, 2026, 10:11 AM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 186 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Acute, Post-operative Pain Clear all

Conditions: Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury, Surgical Wound, Cornea Injury, Cornea, Keratoconus
Interventions: Not listed
Lead sponsor: Boston Children's Hospital; Other
Eligibility: 8 Years to 35 Years
Enrollment: 60 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2021 – 2027
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Thoracotomy, Pain, Postoperative
Interventions: Gabapentin; Drug
Lead sponsor: Indiana University; Other
Eligibility: 18 Years to 70 Years
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Acute Pain, Postoperative Pain Control
Interventions: Experimental: LTG-001 High Dose, Experimental: LTG-001 Low Dose, Active Comparator: HB/APAP, Placebo Comparator; Drug
Lead sponsor: Latigo Biotherapeutics; Industry
Eligibility: 18 Years to 65 Years
Enrollment: 343 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 5
States / cities: Phoenix, Arizona • Atlanta, Georgia • Houston, Texas + 2 more

Conditions: Pain, Postoperative
Interventions: fentanyl; Drug
Lead sponsor: The Medicines Company; Industry
Eligibility: 12 Years to 17 Years
Enrollment: 71 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 10
States / cities: Palo Alto, California • Miami, Florida • Atlanta, Georgia + 7 more

Conditions: Postoperative Pain
Interventions: Maxigesic® IV; Drug
Lead sponsor: AFT Pharmaceuticals, Ltd.; Industry
Eligibility: 18 Years and older
Enrollment: 232 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2020
U.S. locations: 2
States / cities: Pasadena, Maryland • Chapel Hill, North Carolina

Conditions: Post Operative Pain, Acute, Periodontitis
Interventions: Dexamethasone IV injection, Dexamethasone Capsule, Placebo IV administration, Placebo capsule; Drug · Other
Lead sponsor: The University of Texas Health Science Center at San Antonio; Other
Eligibility: 18 Years and older
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2029
U.S. locations: 1
States / cities: San Antonio, Texas

Conditions: Nephrectomy
Interventions: Transverses Abdominis Plane (TAP) block, Quadratus Lumborum (QL) block, Surgeon Infiltration using Exparel; Procedure
Lead sponsor: Indiana University; Other
Eligibility: 18 Years and older
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2018 – 2020
U.S. locations: 1
States / cities: Indianapolis, Indiana

Conditions: Obesity, Morbid, Postoperative Pain, Postoperative Nausea and Vomiting
Interventions: Gabapentin, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 80 Years
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Pain, Postoperative
Interventions: Diclofenac Capsules low dose, Diclofenac Capsules high dose; Drug
Lead sponsor: Iroko Pharmaceuticals, LLC; Industry
Eligibility: 6 Years to 16 Years
Enrollment: 30 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2016
U.S. locations: 5
States / cities: Sheffield, Alabama • Little Rock, Arkansas • Durham, North Carolina + 2 more

Conditions: Post-Operative Pain
Interventions: Sufentanil NanoTab PCA System/15 mcg, morphine IV PCA; Drug
Lead sponsor: Talphera, Inc; Industry
Eligibility: 18 Years and older
Enrollment: 357 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012
U.S. locations: 16
States / cities: Florence, Alabama • Montgomery, Alabama • Sheffield, Alabama + 13 more

Conditions: Moderate to Severe Acute Postoperative Pain
Interventions: Tapentadol; Drug
Lead sponsor: Grünenthal GmbH; Industry
Eligibility: 1 Day to 23 Months
Enrollment: 40 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 4
States / cities: Palo Alto, California • Louisville, Kentucky • Durham, North Carolina + 1 more

Conditions: Fractures, Closed, Pain, Postoperative, Pain Catastrophizing, Pain, Acute, Analgesia, Opioid Use, Acceptance and Commitment Therapy, Orthopedics, Analgesics, Opioid, Text Messaging
Interventions: Acceptance and Commitment Therapy Delivered via an Automated Mobile Messaging Robot; Behavioral
Lead sponsor: Christopher Anthony; Other
Eligibility: 18 Years to 100 Years
Enrollment: 82 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2019
U.S. locations: 1
States / cities: Iowa City, Iowa

Conditions: Anesthesia, Opioid Use, Tonsillitis, Sleep Disorder, Surgery
Interventions: Ketorolac, Dexmedetomidine, Morphine, Fentanyl; Drug
Lead sponsor: Children's Hospital of Philadelphia; Other
Eligibility: 2 Years to 18 Years
Enrollment: 35 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Philadelphia, Pennsylvania • Memphis, Tennessee

Conditions: Postoperative Pain, Acute, Opioid Use, Labral Tear, Glenoid
Interventions: Tylenol, Ibuprofen, and Oxycodone, Tylenol and Ibuprofen only; Drug
Lead sponsor: Cooper Norcross Health; Other
Eligibility: 15 Years to 25 Years
Enrollment: 60 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2025
U.S. locations: 1
States / cities: Camden, New Jersey

Conditions: Post-operation Pain
Interventions: MDT-10013; Drug
Lead sponsor: Medtronic Spinal and Biologics; Industry
Eligibility: 18 Years and older
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016
U.S. locations: 3
States / cities: Birmingham, Alabama • DeLand, Florida • Altoona, Pennsylvania

Conditions: Acute Moderate-to-severe Pain
Interventions: sufentanil sublingual tablet 30 mcg; Drug
Lead sponsor: Talphera, Inc; Industry
Eligibility: 40 Years and older
Enrollment: 140 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016
U.S. locations: 2
States / cities: Houston, Texas

Conditions: Acute Pain
Interventions: Tapentadol oral solution 4 mg/mL, Tapentadol oral solution 20 mg/mL, Placebo; Drug · Other
Lead sponsor: Grünenthal GmbH; Industry
Eligibility: 1 Day to 18 Years
Enrollment: 216 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2019
U.S. locations: 13
States / cities: Little Rock, Arkansas • Stanford, California • Miami, Florida + 9 more

Conditions: Post Operative Pain, Acute
Interventions: Bupivacaine 0.25% Injectable Solution, Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 150 mg, Bupivacaine 0.25% Injectable Solution, Magnesium Sulfate 150 mg, Buprenorphine 300 mcg; Drug
Lead sponsor: Wayne State University; Other
Eligibility: 18 Years to 100 Years
Enrollment: 120 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2021 – 2022
U.S. locations: 1
States / cities: Pontiac, Michigan

Conditions: Postoperative Pain
Interventions: MDT-10013, Standard of care for pain; Drug
Lead sponsor: Medtronic Spinal and Biologics; Industry
Eligibility: 18 Years to 80 Years
Enrollment: 192 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2014 – 2016
U.S. locations: 2
States / cities: Phoenix, Arizona • Austin, Texas

Conditions: Postoperative Pain
Interventions: Q8003 (morphine sulfate and oxycodone hydrochloride), Morphine sulfate, Oxycodone HCl; Drug
Lead sponsor: QRxPharma Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 375 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011
U.S. locations: 4
States / cities: Anaheim, California • Owings Mills, Maryland • Pasadena, Maryland + 1 more

Conditions: Postoperative Pain, Acute Pain
Interventions: Tapentadol; Drug
Lead sponsor: Grünenthal GmbH; Industry
Eligibility: 2 Years to 17 Years
Enrollment: 86 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2014
U.S. locations: 1
States / cities: Salt Lake City, Utah

Conditions: Post op Pain
Interventions: questionnaires; Other
Lead sponsor: East Carolina University; Other
Eligibility: 18 Years and older
Healthy volunteers: Accepts healthy volunteers
Timeline: 2018
U.S. locations: 1
States / cities: Greenville, North Carolina

Conditions: Pain, Postoperative
Interventions: Twin block, iPill dispenser; Drug · Device
Lead sponsor: Rutgers, The State University of New Jersey; Other
Eligibility: 18 Years and older
Enrollment: 133 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: New Brunswick, New Jersey

Conditions: Adenotonsillar Hypertrophy, Obstructive Sleep Apnea, Sleep-Disordered Breathing, Acute Post Operative Pain
Interventions: Ketorolac; Drug
Lead sponsor: St. Louis University; Other
Eligibility: 3 Years to 12 Years
Enrollment: 142 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2022 – 2024
U.S. locations: 1
States / cities: St Louis, Missouri

Search by objective public record fields.

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Gabapentin Dosages for Postoperative Analgesia Following Open Thoracotomy

An Efficacy and Safety Study of LTG-001 Following Abdominoplasty

Safety and Clinical Utility Study of SSEC Fentanyl 40 mcg for Acute Post-op Pain Management in Pediatric Participants

Maxigesic® IV Phase 3 Exposure Study

The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration

Comparing 3 Different Types of Pain Blocks After Laparoscopic Nephrectomy

Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting

Study of Diclofenac Capsules to Treat Pain Following Surgery in Children Ages 6 to <17 Years of Age

A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain

Use of Tapentadol Oral Solution for Pain After Surgery in Children From Newborn to Less Than 2 Years Old

Pain and Narcotic Usage After Orthopaedic Surgery

Opioid-Free Anesthetic for Tonsillectomy

Randomized Trial of Narcotic vs Non-Narcotic Pain Modulation After Labrum Repair

A Feasibility Dose-escalating Study of MDT-10013 for Acute Postoperative Pain Following Total Knee Arthroplasty

A Multicenter, Open-Label Trial to Evaluate the Safety and Efficacy of the Sufentanil Sublingual Tablet 30 mcg in Patients With Post-Operative Pain

A Study to Look at Tapentadol Oral Solution in Children and Adolescents in Pain

Serratus Anterior Plane Block With and Without Adjuvants in Video-assisted Thoracoscopy

A Study of MDT-10013 in the Treatment of Acute Postoperative Pain Following Bunionectomy

Comparison of the Safety of Q8003 Versus Morphine Equivalent Doses of Its Components (Oxycodone and Morphine) in Bunionectomy Patients

Pharmacokinetic, Efficacy and Safety Study of Tapentadol Oral Solution in Children With Postoperative Pain

Phenotyping Acute Pain for Discovery Research and Directed Therapeutics

Reducing Opioid Use and Misuse After Wisdom Molar Extractions

Ketorolac on Postoperative Pain Reduction in Pediatric Patients with Adenotonsillectomy