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Showing 25–48 of 24 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Acute Illness Clear all
Recruiting No phase listed Observational

The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma

NCT06606119
View directory record Official record
Conditions
Trauma Injury, Trauma, Critical Illness, Microbiome, Chronic Anemia, Acute Blood Loss Anemia
Interventions
Data and tissue collection
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years to 100 Years
Enrollment
275 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2028
U.S. locations
3
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Feb 5, 2026 · Synced Sep 25, 2026, 1:10 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Safety and Efficacy of T89 in Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)

NCT03552263
View directory record Official record
Conditions
Acute Mountain Sickness (AMS)
Interventions
T89 capsule, Placebo capsule
Drug
Lead sponsor
Tasly Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 55 Years
Enrollment
132 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2018 – 2019
U.S. locations
1
States / cities
San Francisco, California
Source: ClinicalTrials.gov public record
Updated Nov 12, 2019 · Synced Sep 25, 2026, 1:10 AM EDT
Active, not recruiting Early Phase 1 Interventional Accepts healthy volunteers

The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude

NCT07517068
View directory record Official record
Conditions
Hypoxemia, Acute Mountain Sickness (AMS), Inflammation, Immune Response
Interventions
ACETAZOLAMIDE oral capsule, Placebo Arm
Drug · Device
Lead sponsor
University of California, Riverside
Other
Eligibility
18 Years to 65 Years
Enrollment
19 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2025 – 2026
U.S. locations
1
States / cities
Riverside, California
Source: ClinicalTrials.gov public record
Updated Apr 7, 2026 · Synced Sep 25, 2026, 1:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Efficacy of a Sleep Hygiene Toolkit for Patients in ARU

NCT05541692
View directory record Official record
Conditions
Sleep Disturbance, Sleep Disorder, Insomnia, Critical Illness Myopathy
Interventions
Sleep Hygiene Toolkit
Behavioral
Lead sponsor
University of Southern California
Other
Eligibility
18 Years and older
Enrollment
30 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
Los Angeles, California
Source: ClinicalTrials.gov public record
Updated Sep 14, 2022 · Synced Sep 25, 2026, 1:10 AM EDT
Terminated Phase 3 Interventional Results available

CONvalescent Plasma for Hospitalized Adults With COVID-19 Respiratory Illness (CONCOR-1)

NCT04348656
View directory record Official record
Conditions
COVID-19
Interventions
Convalescent plasma
Biological
Lead sponsor
Hamilton Health Sciences Corporation
Other
Eligibility
16 Years and older
Enrollment
940 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2021
U.S. locations
3
States / cities
Brooklyn, New York • New York, New York
Source: ClinicalTrials.gov public record
Updated Mar 2, 2022 · Synced Sep 25, 2026, 1:10 AM EDT
Completed Phase 2Phase 3 Interventional Results available

EPIC-HR: Study of Oral PF-07321332/Ritonavir Compared With Placebo in Nonhospitalized High Risk Adults With COVID-19

NCT04960202
View directory record Official record
Conditions
COVID-19
Interventions
PF-07321332, Ritonavir, Placebo
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
2,091 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2022
U.S. locations
73
States / cities
Pelham, Alabama • Mesa, Arizona • Tucson, Arizona + 46 more
Source: ClinicalTrials.gov public record
Updated Jul 9, 2025 · Synced Sep 25, 2026, 1:10 AM EDT
Completed Phase 4 Interventional

Sleep Intervention During Acute Lung Injury

NCT01050699
View directory record Official record
Conditions
Critical Illness, Sleep, Acute Lung Injury, Acute Respiratory Distress Syndrome
Interventions
Dexmedetomidine, Midazolam and Fentanyl
Drug
Lead sponsor
University of Arizona
Other
Eligibility
18 Years to 85 Years
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2019
U.S. locations
2
States / cities
Tucson, Arizona
Source: ClinicalTrials.gov public record
Updated Aug 3, 2021 · Synced Sep 25, 2026, 1:10 AM EDT
Not listed Not applicable Interventional

Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients

NCT04669444
View directory record Official record
Conditions
Acute Respiratory Distress Syndrome, Cardiac Failure, Extracorporeal Membrane Oxygenation Complication, Respiratory Failure, Renal Failure, Critical Illness, Pulmonary Disease
Interventions
Ventilator
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
80 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2023
U.S. locations
1
States / cities
La Jolla, California
Source: ClinicalTrials.gov public record
Updated Jan 25, 2023 · Synced Sep 25, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Effect of Advanced Care at Home vs. Traditional Brick-and-Mortar Hospital Care in Acutely Ill Adults: A Pragmatic Clinical Trial

NCT05766956
View directory record Official record
Conditions
Acute Illness
Interventions
Advanced Care at Home (ACH), Traditional Brick-and-Mortar Hospitalization
Other
Lead sponsor
Mayo Clinic
Other
Eligibility
18 Years and older
Enrollment
1,150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
4
States / cities
Phoenix, Arizona • Jacksonville, Florida • Rochester, Minnesota + 1 more
Source: ClinicalTrials.gov public record
Updated Mar 31, 2025 · Synced Sep 25, 2026, 1:10 AM EDT
Not yet recruiting Not applicable Interventional

ICU-SUCCEED for Survivors of Acute Respiratory Failure and Their Caregivers

NCT07778004
View directory record Official record
Conditions
Acute Respiratory Failure, Critical Illness, Sepsis, Hypoxia, Hypercapnia
Interventions
ICU-SUCCEED, Augmented Usual Care
Behavioral · Other
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 99 Years
Enrollment
144 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2030
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 20, 2026 · Synced Sep 25, 2026, 1:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Echinacea and Acute Respiratory Illness

NCT02003651
View directory record Official record
Conditions
Acute Respiratory Infections
Interventions
Quick Defense, Placebo
Dietary Supplement
Lead sponsor
Appalachian State University
Other
Eligibility
18 Years to 55 Years · Female only
Enrollment
40 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2013 – 2014
U.S. locations
1
States / cities
Kannapolis, North Carolina
Source: ClinicalTrials.gov public record
Updated Dec 12, 2016 · Synced Sep 25, 2026, 1:10 AM EDT
Completed Not applicable Interventional Results available

Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study

NCT04663802
View directory record Official record
Conditions
ARDS, Critical Illness, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
Interventions
Default order set, Physician-targeted accountable justification, Respiratory therapist (RT)-targeted accountable justification
Behavioral
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years to 99 Years
Enrollment
7,342 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
5
States / cities
Plainsboro, New Jersey • Philadelphia, Pennsylvania • West Chester, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Oct 7, 2024 · Synced Sep 25, 2026, 1:10 AM EDT
Not yet recruiting Not applicable Interventional

Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit

NCT07811180
View directory record Official record
Conditions
Glucose, Metabolism, Isotope Labeling, Immune System and Related Disorders, Critical Illness, Intensive Care Unit (ICU), Sepsis
Interventions
13C6-Glucose
Drug
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
25 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2028
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 8, 2026 · Synced Sep 25, 2026, 1:10 AM EDT
Suspended Phase 4 Interventional

TEM-PCR™ Prospective Clinical Utility Study

NCT04248361
View directory record Official record
Conditions
Upper Resp Tract Infection
Interventions
TEM-PCR URI Panel, SOC/Empiric Diagnosis
Diagnostic Test · Other
Lead sponsor
Diatherix Laboratories, LLC
Industry
Eligibility
65 Years and older
Enrollment
314 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
4
States / cities
Athens, Alabama • Huntsville, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 19, 2021 · Synced Sep 25, 2026, 1:10 AM EDT
Active, not recruiting Not applicable Interventional

PICU Up!: A Pilot Stepped-wedge Trial of a Multicomponent Early Mobility Intervention for Critically Ill Children

NCT03860168
View directory record Official record
Conditions
Critical Illness
Interventions
PICU Up!
Other
Lead sponsor
Johns Hopkins University
Other
Eligibility
0 Years to 24 Years
Enrollment
2,500 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2026
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 27, 2026 · Synced Sep 25, 2026, 1:10 AM EDT
Not yet recruiting Not applicable Interventional

Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial

NCT07736105
View directory record Official record
Conditions
Dysphagia, Critical Illness
Interventions
Expiratory muscle strength training (EMST), Standard of Care Dysphagia Treatment, Intensive Dysphagia Treatment
Device · Behavioral
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2029
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Sep 25, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment

NCT04067622
View directory record Official record
Conditions
Acute Respiratory Failure, Encephalopathy, ARDS, Sepsis, Critical Illness
Interventions
Exersides
Device
Lead sponsor
University of Vermont
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2021
U.S. locations
3
States / cities
San Diego, California • Baltimore, Maryland • Burlington, Vermont
Source: ClinicalTrials.gov public record
Updated Mar 9, 2022 · Synced Sep 25, 2026, 1:10 AM EDT
Not listed No phase listed Observational

Critical Illness Myopathy and Trajectory of Recovery in AKI Requiring CRRT

NCT05287204
View directory record Official record
Conditions
Acute Kidney Injury, Critical Illness Myopathy, Dialysis; Complications
Interventions
Musculoskeletal ultrasound, Assessments of muscle strength and physical function, Metabolomics
Diagnostic Test
Lead sponsor
University of Iowa
Other
Eligibility
18 Years to 89 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2024
U.S. locations
3
States / cities
Iowa City, Iowa • Lexington, Kentucky • Albuquerque, New Mexico
Source: ClinicalTrials.gov public record
Updated Mar 27, 2024 · Synced Sep 25, 2026, 1:10 AM EDT
Not yet recruiting Early Phase 1 Interventional

Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors

NCT05326633
View directory record Official record
Conditions
Critical Illness, Sarcopenia, ICU Acquired Weakness
Interventions
MRP and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES)
Combination Product
Lead sponsor
University of Maryland, Baltimore
Other
Eligibility
60 Years to 99 Years
Enrollment
78 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2027 – 2029
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated May 5, 2026 · Synced Sep 25, 2026, 1:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

FluSAFE: Flu SMS Alerts to Freeze Exposure

NCT03274310
View directory record Official record
Conditions
Influenza, Acute Respiratory Infection, Influenza-like Illness
Interventions
Educational text messages
Behavioral
Lead sponsor
Columbia University
Other
Eligibility
Not listed
Enrollment
1,918 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2021
U.S. locations
1
States / cities
New York, New York
Source: ClinicalTrials.gov public record
Updated Jan 15, 2025 · Synced Sep 25, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Integrating Palliative Care Social Workers Into Sub-Acute Settings: A Feasibility Trial

NCT03546920
View directory record Official record
Conditions
Advanced Medical Illness
Interventions
ALIGN Intervention Phase
Behavioral
Lead sponsor
University of Colorado, Denver
Other
Eligibility
65 Years and older
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2019
U.S. locations
1
States / cities
Denver, Colorado
Source: ClinicalTrials.gov public record
Updated Jul 9, 2019 · Synced Sep 25, 2026, 1:10 AM EDT
Completed Not applicable Interventional

Saline Against Lactated Ringers or Plasmalyte in the Emergency Department

NCT02614040
View directory record Official record
Conditions
Critical Illness, Acute Kidney Injury
Interventions
0.9% Saline, Physiologically-balanced isotonic crystalloid
Other
Lead sponsor
Vanderbilt University
Other
Eligibility
18 Years and older
Enrollment
14,000 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2017
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Sep 14, 2017 · Synced Sep 25, 2026, 1:10 AM EDT
Recruiting No phase listed Observational

Pervasive Sensing and AI in Intelligent ICU

NCT05127265
View directory record Official record
Conditions
Critical Illness, Pain, Delirium, Confusion
Interventions
Video Monitoring, Accelerometer Monitoring, Noise Level Monitoring, Light Level Monitoring, Air Quality Monitoring, EKG Monitoring, Vitals Monitoring, Biosample Collection, Delirium Motor Subtyping Scale 4 (DMSS-4)
Other
Lead sponsor
University of Florida
Other
Eligibility
18 Years and older
Enrollment
400 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2026
U.S. locations
1
States / cities
Gainesville, Florida
Source: ClinicalTrials.gov public record
Updated Jul 5, 2026 · Synced Sep 25, 2026, 1:10 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

The Physiological Effects of Acute and Ramp Simulated Altitude Exposure During Simulated Flight Tasks

NCT05867719
View directory record Official record
Conditions
Altitude Hypoxia
Interventions
Hypoxic breathing conditions
Other
Lead sponsor
University of Texas, El Paso
Other
Eligibility
18 Years to 40 Years
Enrollment
17 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2026
U.S. locations
1
States / cities
El Paso, Texas
Source: ClinicalTrials.gov public record
Updated May 3, 2026 · Synced Sep 25, 2026, 1:10 AM EDT