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ClinicalTrials.gov public records Last synced Oct 1, 2026, 11:37 AM EDT

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Showing 25–48 of 181 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Acute Pain, Postoperative Clear all
Completed Phase 3 Interventional Results available

A Study to Look at Tapentadol Oral Solution in Children and Adolescents in Pain

NCT02081391
View directory record Official record
Conditions
Acute Pain
Interventions
Tapentadol oral solution 4 mg/mL, Tapentadol oral solution 20 mg/mL, Placebo
Drug · Other
Lead sponsor
Grünenthal GmbH
Industry
Eligibility
1 Day to 18 Years
Enrollment
216 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2019
U.S. locations
13
States / cities
Little Rock, Arkansas • Stanford, California • Miami, Florida + 9 more
Source: ClinicalTrials.gov public record
Updated Jan 18, 2020 · Synced Oct 1, 2026, 11:37 AM EDT
Terminated Not applicable Interventional Results available

Preemptive Femoral & Lateral Femoral Cutaneous Nerve Blocks for THA Acute Pain

NCT01997567
View directory record Official record
Conditions
Internal Derangement of Hip, Acetabular Labrum Tear
Interventions
Ropivacaine, Placebo
Drug
Lead sponsor
Rush University Medical Center
Other
Eligibility
18 Years and older
Enrollment
3 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
1
States / cities
Oak Park, Illinois
Source: ClinicalTrials.gov public record
Updated Oct 3, 2018 · Synced Oct 1, 2026, 11:37 AM EDT
Recruiting Phase 4 Interventional

Meloxicam in Mohs Micrographic Surgery

NCT07200544
View directory record Official record
Conditions
Postoperative Pain, Acute, Skin Cancer
Interventions
Meloxicam 7.5 mg, Meloxicam 15 mg, Acetaminophen 500mg
Drug
Lead sponsor
University of Oklahoma
Other
Eligibility
18 Years to 110 Years
Enrollment
300 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2026
U.S. locations
1
States / cities
Oklahoma City, Oklahoma
Source: ClinicalTrials.gov public record
Updated Dec 15, 2025 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Phase 2 Interventional Results available

Study to Evaluate Analgesic Effect of Intravenous Administration of Kappa Agonist CR845 After Hysterectomy Surgery

NCT00877799
View directory record Official record
Conditions
Acute Pain
Interventions
CR845, Placebo
Drug
Lead sponsor
Cara Therapeutics, Inc.
Industry
Eligibility
21 Years to 60 Years · Female only
Enrollment
114 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2009 – 2010
U.S. locations
12
States / cities
Mobile, Alabama • Sheffield, Alabama • Phoenix, Arizona + 7 more
Source: ClinicalTrials.gov public record
Updated May 12, 2015 · Synced Oct 1, 2026, 11:37 AM EDT
Completed No phase listed Observational

Prospective Observational Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Patients Undergoing Elective Surgical Procedures

NCT02605343
View directory record Official record
Conditions
Acute Pain, Surgery
Interventions
NeuroIDgenetix Test Panel
Other
Lead sponsor
AltheaDx
Industry
Eligibility
18 Years and older
Enrollment
110 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
1
States / cities
Cleveland, Ohio
Source: ClinicalTrials.gov public record
Updated Jun 6, 2016 · Synced Oct 1, 2026, 11:37 AM EDT
Active, not recruiting No phase listed Observational

Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery

NCT03408717
View directory record Official record
Conditions
Breast Cancer, Chronic Pain, Acute Pain, Depression, Anxiety
Interventions
Questionnaires, Mechanical Temporal Summation assessment, Pain threshold assessment
Other
Lead sponsor
KK Women's and Children's Hospital
Government
Eligibility
21 Years to 80 Years · Female only
Enrollment
220 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2018 – 2027
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 7, 2026 · Synced Oct 1, 2026, 11:37 AM EDT
Not yet recruiting Phase 4 Interventional

Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management

NCT07821931
View directory record Official record
Conditions
Tonsillectomy, Pharyngoplasty, Suzetrigine, Opioid, Postoperative Pain, Acute Pain
Interventions
Suzetrigine, Acetaminophen, oxycodone
Drug
Lead sponsor
Stanford University
Other
Eligibility
18 Years and older
Enrollment
58 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2027
U.S. locations
1
States / cities
Palo Alto, California
Source: ClinicalTrials.gov public record
Updated Sep 16, 2026 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Phase 2 Interventional Accepts healthy volunteers

Study of Wafermine™ for Post-bunionectomy or Abdominoplasty Pain

NCT03246971
View directory record Official record
Conditions
Acute Pain, Bunion, Abdominoplasty
Interventions
Wafermine™ 50 mg, Wafermine™ 75 mg, Placebos, Wafermine™ 25 mg
Drug
Lead sponsor
iX Biopharma Ltd.
Other
Eligibility
18 Years to 75 Years
Enrollment
125 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2017 – 2018
U.S. locations
1
States / cities
Pasadena, California
Source: ClinicalTrials.gov public record
Updated Jul 23, 2018 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Phase 2Phase 3 Interventional Accepts healthy volunteers

Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement

NCT05283980
View directory record Official record
Conditions
Pain, Postoperative, Pain, Acute, Pain, Chest, Pain, Satisfaction, Patient, Opioid Use, Unspecified, Opioids; Harmful Use
Interventions
0.25% Bupivacaine
Drug
Lead sponsor
Beth Israel Deaconess Medical Center
Other
Eligibility
18 Years and older
Enrollment
62 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2024
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Jul 30, 2026 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Phase 3 Interventional Results available

An Open-Label Safety Study Of DIC075V (Intravenous Diclofenac Sodium) In Patients With Acute Post-Operative Pain

NCT00726388
View directory record Official record
Conditions
Pain, Postoperative
Interventions
DIC075V (intravenous diclofenac sodium)
Drug
Lead sponsor
Pfizer
Industry
Eligibility
18 Years to 85 Years
Enrollment
1,050 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2009
U.S. locations
46
States / cities
Birmingham, Alabama • Florence, Alabama • Mobile, Alabama + 37 more
Source: ClinicalTrials.gov public record
Updated Oct 13, 2021 · Synced Oct 1, 2026, 11:37 AM EDT
Not yet recruiting Phase 1Phase 2 Interventional

The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration

NCT07832110
View directory record Official record
Conditions
Post Operative Pain, Acute, Periodontitis
Interventions
Dexamethasone IV injection, Dexamethasone Capsule, Placebo IV administration, Placebo capsule
Drug · Other
Lead sponsor
The University of Texas Health Science Center at San Antonio
Other
Eligibility
18 Years and older
Enrollment
40 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Sep 21, 2026 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Not applicable Interventional

Paravertebral Catheters for Pancreatic Surgery

NCT02363777
View directory record Official record
Conditions
Acute Pain
Interventions
Epidural, Paravertebral catheters
Procedure
Lead sponsor
University of Minnesota
Other
Eligibility
18 Years to 85 Years
Enrollment
50 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
1
States / cities
Minneapolis, Minnesota
Source: ClinicalTrials.gov public record
Updated Aug 31, 2017 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Methadone and Hydromorphone For Spinal Surgery

NCT02107339
View directory record Official record
Conditions
Hydromorphone Use, Acute Postoperative Pain, Patient Satisfaction, Chronic Persistent Surgical Pain
Interventions
Methadone, Hydromorphone
Drug
Lead sponsor
Endeavor Health
Other
Eligibility
18 Years to 80 Years
Enrollment
120 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Evanston, Illinois
Source: ClinicalTrials.gov public record
Updated Sep 30, 2019 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Phase 4 Interventional Results available

Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients

NCT01591382
View directory record Official record
Conditions
Postoperative Pain
Interventions
Ketamine, Placebo, Hydromorphone PCA
Drug
Lead sponsor
Brigham and Women's Hospital
Other
Eligibility
18 Years and older
Enrollment
64 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2008 – 2012
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Mar 22, 2017 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Not applicable Interventional Results available

Percutaneous Auricular Neuromodulation for Postoperative Analgesia

NCT05521516
View directory record Official record
Conditions
Postoperative Pain, Acute
Interventions
Active Percutaneous Auricular Neuromodulation with NSS-2 Bridge, Sham Treatment
Device
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
122 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2024
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Mar 4, 2025 · Synced Oct 1, 2026, 11:37 AM EDT
Recruiting Not applicable Interventional

Cold and Compression After Rotator Cuff Repair (RCR)

NCT07516327
View directory record Official record
Conditions
High-grade Partial or Full Thickness Rotator Cuff Tears
Interventions
SOC (Standard of care), Cold and Compression
Other · Device
Lead sponsor
Ochsner Health System
Other
Eligibility
35 Years and older
Enrollment
90 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2029
U.S. locations
1
States / cities
Kenner, Louisiana
Source: ClinicalTrials.gov public record
Updated Apr 14, 2026 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Phase 2 Interventional Results available

Study of Diclofenac Capsules to Treat Pain Following Surgery in Children Ages 6 to <17 Years of Age

NCT02424578
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Diclofenac Capsules low dose, Diclofenac Capsules high dose
Drug
Lead sponsor
Iroko Pharmaceuticals, LLC
Industry
Eligibility
6 Years to 16 Years
Enrollment
30 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2016
U.S. locations
5
States / cities
Sheffield, Alabama • Little Rock, Arkansas • Durham, North Carolina + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 13, 2017 · Synced Oct 1, 2026, 11:37 AM EDT
Recruiting Phase 4 Interventional

Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection

NCT04849455
View directory record Official record
Conditions
Hepatic Resection, Acute Pain, Anesthesia, Anesthesia, Local
Interventions
0.2% ropivacaine local anesthetic continuous erector spinae plane block, 0.2% ropivacaine local anesthetic superficially taped continuous erector spinae plane block, Spinal Morphine
Drug
Lead sponsor
University of California, San Diego
Other
Eligibility
18 Years and older
Enrollment
70 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
1
States / cities
San Diego, California
Source: ClinicalTrials.gov public record
Updated Jun 7, 2022 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Phase 3 Interventional Results available

Maxigesic® IV Phase 3 Exposure Study

NCT04005755
View directory record Official record
Conditions
Postoperative Pain
Interventions
Maxigesic® IV
Drug
Lead sponsor
AFT Pharmaceuticals, Ltd.
Industry
Eligibility
18 Years and older
Enrollment
232 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
2
States / cities
Pasadena, Maryland • Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Sep 1, 2021 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Phase 3 Interventional

Efficacy and Safety of Intranasal Morphine for Pain After Elective Orthopedic Surgery

NCT00390039
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Intranasal morphine, Placebo, IV morphine
Drug
Lead sponsor
Javelin Pharmaceuticals
Industry
Eligibility
18 Years and older
Enrollment
256 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006
U.S. locations
7
States / cities
Phoenix, Arizona • Bakersfield, California • State College, Pennsylvania + 3 more
Source: ClinicalTrials.gov public record
Updated Jan 14, 2008 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Evaluating Intercostobrachial Nerve Block's Effect on Pain Control After Shoulder Replacement

NCT06042608
View directory record Official record
Conditions
Postoperative Pain, Acute, Shoulder Pain
Interventions
intercostobrachial nerve block
Procedure
Lead sponsor
University of Texas Southwestern Medical Center
Other
Eligibility
18 Years to 80 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2025
U.S. locations
1
States / cities
Dallas, Texas
Source: ClinicalTrials.gov public record
Updated Oct 14, 2025 · Synced Oct 1, 2026, 11:37 AM EDT
Recruiting Phase 4 Interventional Accepts healthy volunteers

Scheduled or As Needed Pain Regimen?

NCT06495632
View directory record Official record
Conditions
Pain, Postoperative
Interventions
Motrin and narcotic
Drug
Lead sponsor
Cape Fear Valley Health System
Other
Eligibility
18 Years to 65 Years
Enrollment
90 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2024 – 2027
U.S. locations
1
States / cities
Fayetteville, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 13, 2025 · Synced Oct 1, 2026, 11:37 AM EDT
Not listed Phase 4 Interventional

ZYNRELEF® for Postoperative Analgesia After Laparoscopic Sleeve Gastrectomy

NCT05863221
View directory record Official record
Conditions
Post Operative Pain, Acute, Bariatric Surgery Candidate, Postoperative Pain
Interventions
ZYNRELEF 200Mg-6Mg Extended-Release Solution
Drug
Lead sponsor
Dr. Yannis Raftopoulos
Other
Eligibility
18 Years and older
Enrollment
120 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Holyoke, Massachusetts
Source: ClinicalTrials.gov public record
Updated May 18, 2023 · Synced Oct 1, 2026, 11:37 AM EDT
Completed Not applicable Interventional

Preoperative Psychosocial Support for Postoperative Recovery and Health: Mechanistic Substudy

NCT04520958
View directory record Official record
Conditions
Pain, Acute, Pain, Joint, Pain
Interventions
Mindfulness of Breath, Mindfulness of Pain, Cognitive-Behaviorally Based Pain Psychoeducation
Behavioral
Lead sponsor
University of Utah
Other
Eligibility
18 Years and older
Enrollment
118 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2019 – 2020
U.S. locations
1
States / cities
Salt Lake City, Utah
Source: ClinicalTrials.gov public record
Updated Aug 27, 2020 · Synced Oct 1, 2026, 11:37 AM EDT