Search | Clinical Trials Finder

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ClinicalTrials.gov public records Last synced Nov 14, 2026, 9:12 PM EST

All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.

Showing 1–24 of 214 matching trials from the live ClinicalTrials.gov search.

Filters: Condition: Acute Respiratory Insufficiency Clear all

Conditions: Acute Respiratory Failure
Interventions: Personalized SpO2 Target, Usual Care; Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 3,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2030
U.S. locations: 1
States / cities: Nashville, Tennessee

Conditions: Sepsis, Delirium, Impaired Cognition
Interventions: Dexmedetomidine, Propofol; Drug
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 438 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2013 – 2019
U.S. locations: 11
States / cities: San Francisco, California • Baton Rouge, Louisiana • Boston, Massachusetts + 7 more

Conditions: Acute Respiratory Failure, Covid19
Interventions: Life2000® Ventilator; Device
Lead sponsor: Hill-Rom; Industry
Eligibility: 18 Years and older
Enrollment: 10 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020
U.S. locations: 1
States / cities: Bloomington, Minnesota

Conditions: Respiratory Failure, Multiple Organ Failure
Interventions: PROOFcheck, Standard Care; Other
Lead sponsor: Albert Einstein College of Medicine; Other
Eligibility: 18 Years and older
Enrollment: 34,040 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2018
U.S. locations: 3
States / cities: Jacksonville, Florida • Rochester, Minnesota • The Bronx, New York

Conditions: Acute Respiratory Failure, Mechanical Ventilation, Tracheostomy
Interventions: TRACH-Support; Behavioral
Lead sponsor: Denver Health and Hospital Authority; Other
Eligibility: 18 Years and older
Enrollment: 105 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2024 – 2025
U.S. locations: 1
States / cities: Denver, Colorado

Conditions: Covid19, Urine, Biomarker, Acute Respiratory Failure With Hypoxia
Interventions: Not listed
Lead sponsor: National Center for Global Health and Medicine, Japan; Government
Eligibility: 20 Years and older
Enrollment: 964 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2024
U.S. locations: 1
States / cities: Baltimore, Maryland

Conditions: Acute Liver Failure, Mitochondrial Diseases, End Stage Liver Disease, Respiratory Chain Deficiencies, Mitochondrial, Disorder of Fatty Acid Oxidation
Interventions: Not listed
Lead sponsor: Arbor Research Collaborative for Health; Other
Eligibility: Up to 18 Years
Enrollment: 90 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2010 – 2029
U.S. locations: 15
States / cities: Los Angeles, California • San Francisco, California • Aurora, Colorado + 12 more

Conditions: Acute Respiratory Failure
Interventions: arterial blood gas; Other
Lead sponsor: Brigham and Women's Hospital; Other
Eligibility: 18 Years and older
Enrollment: 646 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2015 – 2020
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: Acute Respiratory Failure
Interventions: Thiamine; Drug
Lead sponsor: Beth Israel Deaconess Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 20 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2012
U.S. locations: 1
States / cities: Boston, Massachusetts

Conditions: CoronaVirus Induced Disease-2019 (COVID-19)
Interventions: Ibrutinib, Placebo; Drug
Lead sponsor: AbbVie; Industry
Eligibility: 18 Years and older
Enrollment: 46 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2021
U.S. locations: 9
States / cities: Stanford, California • Washington D.C., District of Columbia • Ft. Pierce, Florida + 4 more

Conditions: Acute Respiratory Failure
Interventions: Preoxygenation with Non-Invasive Positive Pressure Ventilation, Facemask Oxygen; Other
Lead sponsor: Vanderbilt University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 1,301 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2022 – 2023
U.S. locations: 16
States / cities: Birmingham, Alabama • Aurora, Colorado • Iowa City, Iowa + 13 more

Conditions: Acute Respiratory Distress Syndrome in Children
Interventions: Either supine or prone positioning and either CMV or HFOV; Other
Lead sponsor: University of Pennsylvania; Other
Eligibility: 2 Weeks to 20 Years
Enrollment: 600 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2019 – 2027
U.S. locations: 28
States / cities: Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 24 more

Conditions: Acute Respiratory Failure, Critical Illness
Interventions: Muscle Ultrasound and Muscle Sample; Procedure
Lead sponsor: Wake Forest University Health Sciences; Other
Eligibility: 18 Years and older
Enrollment: 1 participant
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2012 – 2017
U.S. locations: 1
States / cities: Winston-Salem, North Carolina

Conditions: Acute Respiratory Failure, Sepsis
Interventions: Not listed
Lead sponsor: Kirby Mayer; Other
Eligibility: 18 Years to 99 Years
Enrollment: 27 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2025 – 2026
U.S. locations: 1
States / cities: Lexington, Kentucky

Conditions: Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute, Myocarditis Due to Drug, Myocarditis Viral, Pericardial Diseases, Valvular Heart Diseases, Hypertension, Sepsis, Acute Kidney Injury, Pulmonary Edema - Acute, Pulmonary Edema With Heart Failure, Pulmonary Edemas, Acute Respiratory Distress Syndrome, Pulmonary Embolism Acute, Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute Massive, Pulmonary Embolism Subacute Massive, Venous Thrombosis Pulmonary, Venous Thrombosis (Disorder), Venous Thrombosis, Deep, Peripheral Arterial Disease, Peripheral Arterial Disease (PAD), Aortic Diseases, Muskuloskeletal Diseases, Brain Aging, Brain Aneurysm, Brain Aging Related Conditions, Ultrasound, Ultrasound Exams, Ultrasound Guidance
Interventions: OMNIPHYS Multimodal Ultrasound Imaging System; Device
Lead sponsor: Truway Health, Inc.; Industry
Eligibility: 18 Years and older
Enrollment: 25,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2026 – 2046
U.S. locations: 1
States / cities: New York, New York

Conditions: Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Interventions: Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning; Behavioral
Lead sponsor: Rush University Medical Center; Other
Eligibility: 18 Years and older
Enrollment: 2,000 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2026 – 2028
U.S. locations: 1
States / cities: Chicago, Illinois

Conditions: Obesity, Morbid, Postoperative Pain, Postoperative Nausea and Vomiting
Interventions: Gabapentin, Placebo; Drug
Lead sponsor: Medical University of South Carolina; Other
Eligibility: 18 Years to 80 Years
Enrollment: 62 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2008 – 2011
U.S. locations: 1
States / cities: Charleston, South Carolina

Conditions: Acute Lung Injury, Acute Respiratory Distress Syndrome, Respiratory Failure
Interventions: IV Ganciclovir, Placebo; Drug
Lead sponsor: Fred Hutchinson Cancer Center; Other
Eligibility: 18 Years and older
Enrollment: 160 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2011 – 2016
U.S. locations: 14
States / cities: Denver, Colorado • Chicago, Illinois • Springfield, Massachusetts + 10 more

Conditions: COVID, Corona Virus Infection, Respiratory Failure, Respiratory Distress Syndrome, Adult, ARDS, Human, SARS (Severe Acute Respiratory Syndrome)
Interventions: gammaCore® Sapphire (non-invasive vagus nerve stimulator), Standard of care therapies; Device · Other
Lead sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute); Other
Eligibility: 18 Years and older
Enrollment: 21 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2023
U.S. locations: 2
States / cities: Pittsburgh, Pennsylvania

Conditions: Pneumonia, Hypoxemia, Acute Respiratory Failure, COVID-19 Pneumonia
Interventions: Inhaled budesonide and formoterol, Inhaled placebo; Drug
Lead sponsor: Stanford University; Other
Eligibility: 18 Years and older
Enrollment: 465 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2020 – 2025
U.S. locations: 12
States / cities: Birmingham, Alabama • Scottsdale, Arizona • Tucson, Arizona + 8 more

Conditions: Depression
Interventions: Escitalopram, Placebo; Drug
Lead sponsor: University of Minnesota; Other
Eligibility: 25 Years and older
Enrollment: 15 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2009 – 2011
U.S. locations: 1
States / cities: Minneapolis, Minnesota

Conditions: Acute Respiratory Distress Syndrome, ARDS, Respiratory Distress Syndrome, Acute, Respiratory Insufficiency, Respiratory Distress Syndrome, Shock Lung, Severe Acute Respiratory Syndrome
Interventions: Not listed
Lead sponsor: Intermountain Health Care, Inc.; Other
Eligibility: 18 Years and older
Enrollment: 8,692 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016 – 2022
U.S. locations: 1
States / cities: Murray, Utah

Conditions: Acute Respiratory Failure
Interventions: External nasal dilator (END), High flow nasal cannula (HFNC); Device · Other
Lead sponsor: Loma Linda University; Other
Eligibility: 1 Day to 18 Years
Enrollment: 55 participants
Healthy volunteers: Healthy volunteers not accepted
Timeline: 2016
U.S. locations: 1
States / cities: Loma Linda, California

Conditions: Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure, Acute Respiratory Failure With Hypoxia, Acute Respiratory Failure With Hypercapnia, Acute Respiratory Failure Post Surgical, Acute Respiratory Failure Postprocedural, Acute Respiratory Failure Following Trauma and Surgery, Acute Respiratory Failure Requiring Reintubation, Acute Respiratory Failure Post Traumatic, Acute Respiratory Decompensation, Shock, Shock, Septic, Shock, Cardiogenic, Acute Cardiac Failure, Multi Organ Failure, Acute Kidney Failure
Interventions: Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data; Other
Lead sponsor: Efficacy Care R&D Ltd; Industry
Eligibility: 18 Years to 90 Years
Enrollment: 50,000 participants
Healthy volunteers: Accepts healthy volunteers
Timeline: 2019 – 2020
U.S. locations: 1
States / cities: Houston, Texas

Search by objective public record fields.

Examination of Personalized SpO2 Targets

The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure

Proportional Open Ventilation (POV) Device and Its Efficacy in Managing Acute Respiratory Failure in COVID-19 Patients

Prevention of Severe Acute Respiratory Failure in Patients With PROOFCheck

Personalized Decision-Aid to Guide Tracheostomy and Prolonged Mechanical Ventilation Decision-Making

Risk Stratification of COVID-19 Using Urine Biomarkers

Longitudinal Study of Mitochondrial Hepatopathies

Imputation of PaO2 From SaO2

Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness

Study of Oral Ibrutinib Capsules to Assess Respiratory Failure in Adult Participants With Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Pulmonary Injury

Pragmatic Trial Examining Oxygenation Prior to Intubation

PROSpect: Prone and Oscillation Pediatric Clinical Trial

Muscle Ultrasound Signifies Condition Upgrade Leading Approach to Recovery

Virtual Reality in ICU - PARTNER

Multimodal Physiologic State Intelligence Study

Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients

Study of the Effect of the Drug Gabapentin on Postoperative Pain and Incidence of Postoperative Nausea and Vomiting

Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure

Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms

ARrest RESpiraTory Failure From PNEUMONIA

Preventing Depression in People Receiving Mechanical Ventilation in an Intensive Care Unit

Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure

External Nasal Dilator and Oxygen Therapy in Respiratory Failure

Postoperative Respiratory Abnormalities