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Showing 1–24 of 30 matching trials from the live ClinicalTrials.gov search.
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Filters: Condition: Acute Sinusitis Clear all
Terminated No phase listed Observational

Point-of-Care Immunoassay for Detection of Bacterial Sinusitis

NCT03584737
View directory record Official record
Conditions
Sinusitis Bacterial
Interventions
rapid in vitro diagnostic test, bacterial culture, PCR assay
Diagnostic Test
Lead sponsor
ENTvantage Dx
Industry
Eligibility
18 Years and older
Enrollment
800 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2021 – 2023
U.S. locations
7
States / cities
Sacramento, California • DeLand, Florida • Port Saint Lucie, Florida + 4 more
Source: ClinicalTrials.gov public record
Updated Apr 11, 2023 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Not applicable Interventional Results available

Comparison of Balloon Sinuplasty In-Office Versus Medical Management for Recurrent Acute Sinusitis Patients (CABERNET)

NCT01714687
View directory record Official record
Conditions
Recurrent Acute Rhinosinusitis
Interventions
balloon sinus dilation, medical therapy
Device · Other
Lead sponsor
Integra LifeSciences Corporation
Industry
Eligibility
19 Years and older
Enrollment
59 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2016
U.S. locations
5
States / cities
Birmingham, Alabama • Atlanta, Georgia • Las Vegas, Nevada + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 11, 2024 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Not applicable Interventional

Antimicrobial Stewardship for Primary Care Pediatricians

NCT01806103
View directory record Official record
Conditions
Acute Sinusitis, Streptococcal Pharyngitis, Pneumonia, Viral Infection
Interventions
Antimicrobial Stewardship Bundle
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
Not listed
Enrollment
170 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2012
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 6, 2013 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Broad Implementation of Outpatient Stewardship

NCT05127161
View directory record Official record
Conditions
Acute Respiratory Tract Infection, Otitis Media, Pharyngitis, Acute Sinusitis
Interventions
Broad Implementation of Outpatient Stewardship (BIOS) intervention
Behavioral
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
6 Months to 12 Years
Enrollment
1,032 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022 – 2025
U.S. locations
5
States / cities
Plantation, Florida • Cleveland, Ohio • Hershey, Pennsylvania + 1 more
Source: ClinicalTrials.gov public record
Updated Feb 8, 2026 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Phase 3 Interventional Accepts healthy volunteers

A Trial of Point of Care Information in Ambulatory Pediatrics

NCT00368823
View directory record Official record
Conditions
Acute Otitis Media, Allergic Rhinitis, Sinusitis, Constipation, Pharyngitis, Croup, Urticaria, Bronchiolitis
Interventions
Electronic point-of-care delivery system
Device
Lead sponsor
University of Washington
Other
Eligibility
0 Years and older
Enrollment
44 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
1999 – 2003
U.S. locations
2
States / cities
Seattle, Washington • Skagit Valley, Washington
Source: ClinicalTrials.gov public record
Updated Aug 28, 2006 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Phase 3 Interventional Results available

BAY12-8039: 5 Days for Sinusitis vs Placebo

NCT00492024
View directory record Official record
Conditions
Sinusitis
Interventions
Moxifloxacin (Avelox, BAY12-8039), Placebo
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years and older
Enrollment
374 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2008
U.S. locations
51
States / cities
Birmingham, Alabama • Northport, Alabama • Jonesboro, Arkansas + 45 more
Source: ClinicalTrials.gov public record
Updated Nov 25, 2013 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Phase 4 Interventional

Study of the Safety and Efficacy of Cefdinir and Levofloxacin for the Treatment of Subjects With Acute Bacterial Sinusitis

NCT00645073
View directory record Official record
Conditions
Acute Bacterial Sinusitis
Interventions
cefdinir (Omnicef), levofloxacin
Drug
Lead sponsor
Abbott
Industry
Eligibility
18 Years and older
Enrollment
271 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
23
States / cities
Birmingham, Alabama • Columbiana, Alabama • Eclectic, Alabama + 16 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2008 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Phase 4 Interventional

Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox

NCT00668304
View directory record Official record
Conditions
Maxillary Sinusitis
Interventions
Avelox (Moxifloxacin, BAY12-8039)
Drug
Lead sponsor
Bayer
Industry
Eligibility
18 Years and older
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2004 – 2005
U.S. locations
29
States / cities
Birmingham, Alabama • Hoover, Alabama • Jonesboro, Arkansas + 26 more
Source: ClinicalTrials.gov public record
Updated Dec 18, 2014 · Synced Sep 5, 2026, 2:32 PM EDT
Not yet recruiting Phase 4 Interventional

Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children (Acute Sinusitis)

NCT07732699
View directory record Official record
Conditions
ACUTE SINUSITIS, Sinusitis
Interventions
Amoxicillin, Amoxi Clavulanate, Amoxicillin Placebo, Amoxicillin-Clavulanate Placebo
Drug
Lead sponsor
Nader Shaikh
Other
Eligibility
2 Years to 12 Years
Enrollment
1,100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2026 – 2032
U.S. locations
5
States / cities
Denver, Colorado • Durham, North Carolina • Cincinnati, Ohio + 2 more
Source: ClinicalTrials.gov public record
Updated Jul 28, 2026 · Synced Sep 5, 2026, 2:32 PM EDT
Active, not recruiting No phase listed Observational

Reducing Antibiotic Use by Implementation of Stewardship in Primary and Urgent Care

NCT07217002
View directory record Official record
Conditions
Community Acquired Pneumonia (CAP), Sinusitis, Strep Pharyngitis, Acute Otitis Media (AOM)
Interventions
Online Educational Modules, Prescribing Feedback Reports, Clinical Decision Support, Live, hybrid in-person and online educational sessions
Other
Lead sponsor
Children's Hospital of Philadelphia
Other
Eligibility
6 Months to 12 Years
Enrollment
420 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025 – 2029
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Apr 13, 2026 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Phase 4 Interventional Results available

Treatment of Acute Sinusitis

NCT00377403
View directory record Official record
Conditions
Acute Respiratory Infections, Acute Rhinosinusitis
Interventions
Acetaminophen, Amoxicillin, Dextromethorphan hydrobromide with guaifenesin, Guaifenesin, Pseudoephedrine Sustained Action, Saline spray (0.65%)
Drug
Lead sponsor
Washington University School of Medicine
Other
Eligibility
18 Years to 70 Years
Enrollment
172 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2010
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Dec 27, 2012 · Synced Sep 5, 2026, 2:32 PM EDT
Terminated Phase 1Phase 2 Interventional Results available

Topical Irrigation Therapy for CRS

NCT02630472
View directory record Official record
Conditions
Rhinitis, Sinusitis
Interventions
Quinine Sulfate, Placebo
Drug
Lead sponsor
University of Pennsylvania
Other
Eligibility
18 Years and older
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015 – 2017
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Mar 12, 2019 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Not applicable Interventional

Pilot Study to Determine Efficacy of Cyclamen Europaeum Extract Nasal Spray in Patients With Acute Sinusitis

NCT00552773
View directory record Official record
Conditions
ACUTE SINUSITIS
Interventions
Cyclamen Europaeum
Drug
Lead sponsor
Dey
Industry
Eligibility
18 Years to 70 Years
Enrollment
48 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007 – 2009
U.S. locations
25
States / cities
Birmingham, Alabama • Oxford, Alabama • Jonesboro, Arkansas + 19 more
Source: ClinicalTrials.gov public record
Updated Jun 3, 2013 · Synced Sep 5, 2026, 2:32 PM EDT
Terminated Phase 4 Interventional

Study to Measure the Impact of Antibiotics on Bacterial Flora in Adults With Acute Sinusitis

NCT00245440
View directory record Official record
Conditions
Maxillary Sinusitis
Interventions
Azithromycin, Telithromycin
Drug
Lead sponsor
CPL Associates
Other
Eligibility
18 Years to 75 Years
Enrollment
192 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2006
U.S. locations
1
States / cities
Taylors, South Carolina
Source: ClinicalTrials.gov public record
Updated Oct 30, 2007 · Synced Sep 5, 2026, 2:32 PM EDT
Withdrawn Phase 3 Interventional

Pulmozyme in Cystic Fibrosis With Sinusitis

NCT01155752
View directory record Official record
Conditions
Sinusitis, Cystic Fibrosis
Interventions
Pulmozyme single use ampule, placebo
Drug
Lead sponsor
Milton S. Hershey Medical Center
Other
Eligibility
12 Years to 65 Years
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2015
U.S. locations
1
States / cities
Hershey, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jul 20, 2017 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Phase 3 Interventional

Comparative Study of the Safety and Efficacy of Clarithromycin Extended-Release Tablets Versus Amoxicillin-Clavulanate for the Treatment of Acute Bacterial Sinusitis

NCT00644553
View directory record Official record
Conditions
Acute Bacterial Sinusitis (ABS)
Interventions
Clarithromycin, Amoxicillin
Drug
Lead sponsor
Abbott
Industry
Eligibility
12 Years and older
Enrollment
437 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
Started 2003
U.S. locations
12
States / cities
Birmingham, Alabama • Phoenix, Arizona • Clovis, California + 9 more
Source: ClinicalTrials.gov public record
Updated Mar 26, 2008 · Synced Sep 5, 2026, 2:32 PM EDT
Not listed Phase 2 Interventional

GLS-1200 Topical Nasal Spray to Prevent Sinusitis After Endoscopic Sinus Surgery

NCT04060316
View directory record Official record
Conditions
Sinusitis Chronic
Interventions
GLS-1200, Placebo
Drug
Lead sponsor
GeneOne Life Science, Inc.
Industry
Eligibility
18 Years and older
Enrollment
99 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
1
States / cities
Philadelphia, Pennsylvania
Source: ClinicalTrials.gov public record
Updated Jan 10, 2023 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Not applicable Interventional

Guidelines for Acute Sinusitis

NCT00132275
View directory record Official record
Conditions
Sinusitis
Interventions
Amoxicillin potassium clavulanate
Drug
Lead sponsor
University of Pittsburgh
Other
Eligibility
1 Year to 10 Years
Enrollment
240 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2006
U.S. locations
1
States / cities
Pittsburgh, Pennsylvania
Source: ClinicalTrials.gov public record
Updated May 19, 2008 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Phase 3 Interventional Results available

Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit?

NCT02554383
View directory record Official record
Conditions
Sinusitis, Respiratory Tract Infections
Interventions
Amoxicillin-clavulanate, Placebo
Drug
Lead sponsor
Nader Shaikh
Other
Eligibility
2 Years to 11 Years
Enrollment
515 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2016 – 2023
U.S. locations
6
States / cities
Bardstown, Kentucky • Gresham, Oregon • Philadelphia, Pennsylvania + 3 more
Source: ClinicalTrials.gov public record
Updated Jun 28, 2023 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Phase 3 Interventional

A Multicenter, Randomized, Double-Blind, Double-Dummy Trial of Azithromycin SR Compared With Levofloxacin for the Treatment of Sinus Infections in Adults

NCT00643409
View directory record Official record
Conditions
Maxillary Sinusitis
Interventions
azithromycin SR (Zithromax; compound: CP-62,993), placebo, levofloxacin
Drug · Other
Lead sponsor
Pfizer
Industry
Eligibility
18 Years and older
Enrollment
541 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2003 – 2004
U.S. locations
59
States / cities
Alabaster, Alabama • Birmingham, Alabama • Hueytown, Alabama + 37 more
Source: ClinicalTrials.gov public record
Updated May 10, 2011 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Phase 4 Interventional Accepts healthy volunteers Results available

Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate

NCT02340000
View directory record Official record
Conditions
Sinusitis
Interventions
standard dose amoxicillin/clavulanate, high dose amoxicillin/clavulanate
Drug
Lead sponsor
Albany Medical College
Other
Eligibility
18 Years and older
Enrollment
315 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2014 – 2017
U.S. locations
1
States / cities
Latham, New York
Source: ClinicalTrials.gov public record
Updated Aug 23, 2017 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Phase 4 Interventional

Phase 4 Study - Mucinex D as Adjunct Therapy

NCT00441246
View directory record Official record
Conditions
Acute Respiratory Infection, Bronchitis, Rhinosinusitis
Interventions
Mucinex D (600 mg guaifenesin and 60 mg pseudoephedrine HCl extended-release bi-layer tablets)
Drug
Lead sponsor
Adams Respiratory Therapeutics
Industry
Eligibility
18 Years to 75 Years
Enrollment
600 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2007
U.S. locations
28
States / cities
Birmingham, Alabama • Carmichael, California • Torrance, California + 24 more
Source: ClinicalTrials.gov public record
Updated Feb 5, 2008 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Phase 1 Interventional

Pharmacokinetic Profiles Of Amoxicillin 2000 mg And Clavulanate 125 mg In Adolescent Patients

NCT00354965
View directory record Official record
Conditions
Infections, Respiratory Tract
Interventions
amoxicillin/clavulanate potassium
Drug
Lead sponsor
GlaxoSmithKline
Industry
Eligibility
Up to 16 Years
Enrollment
52 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2006 – 2007
U.S. locations
6
States / cities
Little Rock, Arkansas • Huntington Beach, California • North Dartmouth, Massachusetts + 3 more
Source: ClinicalTrials.gov public record
Updated Jul 31, 2017 · Synced Sep 5, 2026, 2:32 PM EDT
Completed Phase 4 Interventional

Comparison Study Between Cefdinir & Amoxicilline/Clavulanate in Acute Sinusitis and Assessment of Quality of Life

NCT00147914
View directory record Official record
Conditions
Acute Bacterial Sinusitis
Interventions
Cefdinir (drug), amoxicillin/clavulanate
Drug
Lead sponsor
University of Chicago
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2005 – 2017
U.S. locations
1
States / cities
Chicago, Illinois
Source: ClinicalTrials.gov public record
Updated May 1, 2017 · Synced Sep 5, 2026, 2:32 PM EDT