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ClinicalTrials.gov public records Last synced Oct 18, 2026, 10:45 AM EDT

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Showing 385–408 of 625 matching trials from the live ClinicalTrials.gov search.
Filters: Condition: Adult Obesity Clear all
Completed Not applicable Interventional Accepts healthy volunteers

Effects of Avenanthramide-enriched Oats on Inflammation

NCT01527604
View directory record Official record
Conditions
Inflammation
Interventions
Avenanthramide-enriched oats, Refined flour absent avenanthramides
Other
Lead sponsor
Tufts University
Other
Eligibility
50 Years and older
Enrollment
16 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2012 – 2014
U.S. locations
1
States / cities
Boston, Massachusetts
Source: ClinicalTrials.gov public record
Updated Nov 19, 2014 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Lifestyle Intervention Trial in Obese Elderly

NCT01065636
View directory record Official record
Conditions
Obesity
Interventions
Diet + Resistance Training, Diet + Aerobic Training, Diet + Resistance/Aerobic Exercise
Behavioral
Lead sponsor
Biomedical Research Institute of New Mexico
Other
Eligibility
65 Years to 85 Years
Enrollment
160 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2010 – 2018
U.S. locations
2
States / cities
Albuquerque, New Mexico • Houston, Texas
Source: ClinicalTrials.gov public record
Updated Jan 22, 2020 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Exercise Dose Response for Improving Insulin Sensitivity

NCT01452035
View directory record Official record
Conditions
Obesity
Interventions
Exercise
Other
Lead sponsor
University of Michigan
Other
Eligibility
18 Years to 45 Years
Enrollment
13 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2009 – 2015
U.S. locations
1
States / cities
Ann Arbor, Michigan
Source: ClinicalTrials.gov public record
Updated Nov 8, 2016 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Study to Assess S-309309 in Healthy and Obese Participants

NCT05247970
View directory record Official record
Conditions
Obesity
Interventions
S-309309, Midazolam, Placebo
Drug
Lead sponsor
Shionogi
Industry
Eligibility
18 Years to 55 Years
Enrollment
74 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2022
U.S. locations
1
States / cities
San Antonio, Texas
Source: ClinicalTrials.gov public record
Updated Jan 11, 2023 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Phase 3 Interventional

A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

NCT05803421
View directory record Official record
Conditions
Type 2 Diabetes, Obesity, Overweight or Obesity, Overweight, Cardiovascular Diseases, Chronic Kidney Disease
Interventions
Orforglipron, Insulin Glargine
Drug
Lead sponsor
Eli Lilly and Company
Industry
Eligibility
18 Years and older
Enrollment
2,749 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2026
U.S. locations
173
States / cities
Daphne, Alabama • Mobile, Alabama • Pelham, Alabama + 149 more
Source: ClinicalTrials.gov public record
Updated Apr 17, 2026 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers Results available

Enhanced DPP-GLB to Promote Weight Loss Among Nonresponders in a Community-Based Lifestyle Intervention.

NCT04757519
View directory record Official record
Conditions
Diabetes
Interventions
DPP-GLB Standard, DPP-GLB Enhanced
Behavioral
Lead sponsor
Lovoria Williams
Other
Eligibility
18 Years and older
Enrollment
403 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2021 – 2026
U.S. locations
21
States / cities
Frankfort, Kentucky • Lexington, Kentucky • Louisville, Kentucky + 2 more
Source: ClinicalTrials.gov public record
Updated Jun 24, 2026 · Synced Oct 18, 2026, 10:45 AM EDT
Not listed Phase 2 Interventional Accepts healthy volunteers

Efficacy of Pharmacological Stimulation of BAT and WAT in Lean and Obese Young Adults

NCT02354807
View directory record Official record
Conditions
Brown Fat
Interventions
Mirabegron, Cold exposure
Drug · Other
Lead sponsor
Otto Muzik
Other
Eligibility
18 Years to 40 Years
Enrollment
20 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2018
U.S. locations
1
States / cities
Detroit, Michigan
Source: ClinicalTrials.gov public record
Updated May 10, 2017 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Phase 2 Interventional

Safety and Efficacy Study of S-309309 in Obese Adults

NCT05925114
View directory record Official record
Conditions
Obesity
Interventions
S-309309, Placebo
Drug
Lead sponsor
Shionogi
Industry
Eligibility
18 Years and older
Enrollment
365 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2024
U.S. locations
49
States / cities
Birmingham, Alabama • Phoenix, Arizona • Los Angeles, California + 40 more
Source: ClinicalTrials.gov public record
Updated Apr 16, 2025 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Healthy Lifestyles After Cancer for Adolescents and Young Adults: A Program to Reduce Cardiovascular Risk Factors

NCT05869604
View directory record Official record
Conditions
Cancer, Cardiovascular Diseases, Weight Management, Pain, Fatigue, Distress, Emotional, Physical Inactivity
Interventions
HEALTHY AYA, Education Control
Behavioral · Other
Lead sponsor
Duke University
Other
Eligibility
18 Years to 39 Years
Enrollment
38 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Durham, North Carolina
Source: ClinicalTrials.gov public record
Updated Mar 31, 2026 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers

A Multiple Dose Study to Assess the Safety and Tolerability of BMS-963272 in Obese But Otherwise Healthy Adults

NCT04116632
View directory record Official record
Conditions
Obese But Otherwise Healthy Participants
Interventions
BMS-963272, Placebo
Drug
Lead sponsor
Bristol-Myers Squibb
Industry
Eligibility
18 Years to 60 Years
Enrollment
36 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2020
U.S. locations
1
States / cities
Lenexa, Kansas
Source: ClinicalTrials.gov public record
Updated May 15, 2020 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Behavioral Lifestyle Intervention for Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) in Adults

NCT06121999
View directory record Official record
Conditions
Metabolic Associated-dysfunction Steatotic Liver Disease (MASLD), Metabolic Associated-dysfunction Steatohepatitis (MASH)
Interventions
Standard of care acceptance-based behavioral weight loss program, Occupational therapy dietary and lifestyle modifications
Behavioral
Lead sponsor
Grand Valley State University
Other
Eligibility
18 Years and older
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2023 – 2024
U.S. locations
1
States / cities
Wyoming, Michigan
Source: ClinicalTrials.gov public record
Updated Aug 28, 2025 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Effects of ISOThrive on Bodyweight, Body Composition, Hunger/Satiety and Cardiac Risk Measures in Overweight Adults

NCT02501356
View directory record Official record
Conditions
Obesity
Interventions
ISOThrive Supplement, Placebo Supplement
Dietary Supplement
Lead sponsor
Griffin Hospital
Other
Eligibility
18 Years to 75 Years
Enrollment
103 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2015
U.S. locations
1
States / cities
Derby, Connecticut
Source: ClinicalTrials.gov public record
Updated Mar 26, 2020 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Phase 1 Interventional Accepts healthy volunteers Results available

Safety and Tolerability Study of SHP626 in Overweight and Obese Adults

NCT02287779
View directory record Official record
Conditions
Non-Alcoholic Steatohepatitis
Interventions
SHP626, Placebo
Drug
Lead sponsor
Mirum Pharmaceuticals, Inc.
Industry
Eligibility
18 Years to 65 Years
Enrollment
84 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015
U.S. locations
1
States / cities
Knoxville, Tennessee
Source: ClinicalTrials.gov public record
Updated Mar 26, 2019 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Phase 4 Interventional Results available

A Multicenter, Double-blind, Randomized, Parallel-group, Pilot Study of 12-week Duration to Assess the Short-term Safety and Tolerability of Lorcaserin Plus Two Doses of Immediate-Release Phentermine-HCl Compared With Lorcaserin Alone in Overweight and Obese Adults

NCT01987427
View directory record Official record
Conditions
Chronic Weight Management
Interventions
lorcaserin + phentermine placebo, lorcaserin + phentermine-HCl + phentermine placebo, lorcaserin + phentermine-HCl
Drug
Lead sponsor
Eisai Inc.
Industry
Eligibility
18 Years to 60 Years
Enrollment
344 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2013 – 2014
U.S. locations
13
States / cities
Birmingham, Alabama • Chandler, Arizona • La Jolla, California + 10 more
Source: ClinicalTrials.gov public record
Updated Sep 30, 2019 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Not applicable Interventional

Anti-Inflammatory Effects Of Frequency Specific Microcurrent (FSM) In Osteoarthritic Adults

NCT06390137
View directory record Official record
Conditions
Osteoarthritis
Interventions
Frequency Specific Microcurrent, Sham microcurrent treatment
Device
Lead sponsor
Nova Southeastern University
Other
Eligibility
18 Years to 100 Years
Enrollment
10 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2025
U.S. locations
1
States / cities
Lakeland, Florida
Source: ClinicalTrials.gov public record
Updated Jun 18, 2026 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Phase 2 Interventional Results available

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Miricorilant in Obese Adult Patients With Schizophrenia While Taking Antipsychotic Medications (GRATITUDE II)

NCT04524403
View directory record Official record
Conditions
Antipsychotic-induced Weight Gain (AIWG)
Interventions
Miricorlilant, Placebo
Drug
Lead sponsor
Corcept Therapeutics
Industry
Eligibility
18 Years to 65 Years
Enrollment
150 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2020 – 2022
U.S. locations
40
States / cities
Bentonville, Arkansas • Little Rock, Arkansas • Culver City, California + 33 more
Source: ClinicalTrials.gov public record
Updated Jun 13, 2024 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Egg Diet to Improve Metabolic Health and Function

NCT02760641
View directory record Official record
Conditions
Obesity
Interventions
Egg-based diet (EBD), Carbohydrate-based diet (CBD)
Other
Lead sponsor
University of Alabama at Birmingham
Other
Eligibility
60 Years to 75 Years
Enrollment
34 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2015 – 2017
U.S. locations
1
States / cities
Birmingham, Alabama
Source: ClinicalTrials.gov public record
Updated Aug 21, 2017 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Phase 1 Interventional Results available

Multiple Dose Study Of PF-05231023 In Adult Subjects Who Have Poor Lipid Control With And Without Type 2 Diabetes Mellitus

NCT01673178
View directory record Official record
Conditions
Diabetes Melliuts, Type 2
Interventions
Placebo, 25 mg PF-05231023, 50 mg PF-05231023, 100 mg PF-05231023, 150 mg PF-05231023
Other · Drug
Lead sponsor
Pfizer
Industry
Eligibility
30 Years to 70 Years
Enrollment
107 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2012 – 2013
U.S. locations
17
States / cities
Anaheim, California • Chula Vista, California • Walnut Creek, California + 10 more
Source: ClinicalTrials.gov public record
Updated Feb 16, 2015 · Synced Oct 18, 2026, 10:45 AM EDT
Completed No phase listed Observational Accepts healthy volunteers

Pain and Acetaminophen in Women Study

NCT04573426
View directory record Official record
Conditions
Overweight, Obesity, Healthy Adults
Interventions
Acetaminophen, Placebo, Weight stigma vignette, Control vignette
Drug · Behavioral
Lead sponsor
Ohio State University
Other
Eligibility
18 Years and older · Female only
Enrollment
200 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2019 – 2021
U.S. locations
1
States / cities
Columbus, Ohio
Source: ClinicalTrials.gov public record
Updated Sep 8, 2021 · Synced Oct 18, 2026, 10:45 AM EDT
Active, not recruiting Phase 2 Interventional

Glucagon-Like Peptide-1 Receptor Agonist in the Treatment of Adult, Obesity-related, Symptomatic Asthma (GATA-3)

NCT05254314
View directory record Official record
Conditions
Asthma
Interventions
Semaglutide Pen Injector 2.4mg weekly, Placebo
Drug · Other
Lead sponsor
Vanderbilt University Medical Center
Other
Eligibility
18 Years and older
Enrollment
100 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2022 – 2026
U.S. locations
1
States / cities
Nashville, Tennessee
Source: ClinicalTrials.gov public record
Updated Oct 1, 2026 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Use of a Soy-based Meal Replacement Weight Loss Intervention to Impact Ectopic Fat

NCT01298817
View directory record Official record
Conditions
Abdominal Obesity
Interventions
Medifast meal replacement products
Dietary Supplement
Lead sponsor
Wake Forest University Health Sciences
Other
Eligibility
60 Years to 79 Years
Enrollment
24 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2011 – 2012
U.S. locations
1
States / cities
Winston-Salem, North Carolina
Source: ClinicalTrials.gov public record
Updated Aug 15, 2018 · Synced Oct 18, 2026, 10:45 AM EDT
Recruiting Not applicable Interventional Accepts healthy volunteers

Two-Week Stair-Climbing Exercise Snacks and Metabolic Health in Adults With Overweight or Obesity: A Pilot Study

NCT07849439
View directory record Official record
Conditions
Overweight , Obesity
Interventions
Stair-Climbing Exercise Snacks
Behavioral
Lead sponsor
St. Louis University
Other
Eligibility
18 Years to 35 Years
Enrollment
12 participants
Healthy volunteers
Accepts healthy volunteers
Timeline
2026 – 2027
U.S. locations
1
States / cities
St Louis, Missouri
Source: ClinicalTrials.gov public record
Updated Sep 30, 2026 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Not applicable Interventional Accepts healthy volunteers

Weight Loss in Diabetic, Older Obese Adults

NCT00108329
View directory record Official record
Conditions
Metabolic Syndrome X
Interventions
Weight Loss
Behavioral
Lead sponsor
US Department of Veterans Affairs
Federal
Eligibility
50 Years and older
Healthy volunteers
Accepts healthy volunteers
Timeline
2003 – 2006
U.S. locations
1
States / cities
Baltimore, Maryland
Source: ClinicalTrials.gov public record
Updated Jan 21, 2009 · Synced Oct 18, 2026, 10:45 AM EDT
Completed Not applicable Interventional Results available

Just-in-time Adaptive Intervention Messaging in a Digital Weight Loss Intervention for Young Adults

NCT05625061
View directory record Official record
Conditions
Obesity, Overweight, Overweight and Obesity
Interventions
Core Behavioral Weight Loss (BWL) Intervention, Behavior Change Technique 1 Message (Action Planning), Behavior Change Technique 2 Message (Discrepancy between Current Behavior and Goal), Behavior Change Technique 3 Message (Feedback on Outcome of Behavior), Behavior Change Technique 4 Message (Social Support), Behavior Change Technique 5 Message (Social Comparison), Behavior Change Technique 6 Message (Social Reward), Behavior Change Technique 7 Message (Focus on Past Success)
Behavioral
Lead sponsor
University of North Carolina, Chapel Hill
Other
Eligibility
18 Years to 39 Years
Enrollment
255 participants
Healthy volunteers
Healthy volunteers not accepted
Timeline
2023 – 2025
U.S. locations
1
States / cities
Chapel Hill, North Carolina
Source: ClinicalTrials.gov public record
Updated Feb 17, 2026 · Synced Oct 18, 2026, 10:45 AM EDT